Abstract: A method is disclosed for requesting genomics services from a service provider over the Internet and providing genomics services to a client over the Internet. The client provides biological samples and identifies genome sequences of interest. The service provider obtains the biological samples and genome sequences, provides microarrays containing the identified genome sequences, and applies the biological samples to the microarrays. The client receives the results of the analysis over the Internet. The genomics services provided include genotyping, gene expression, and proteomics. The Client is able over the Internet to obtain the current status of the samples and the experiments and to modify the requested experiments based, for example, on the analysis of previously obtained results.

Abstract: A method is disclosed for requesting genomics services from a service provider over the Internet and providing genomics services to a client over the Internet. The client provides biological samples and identifies genome sequences of interest. The service provider obtains the biological samples and genome sequences, provides microarrays containing the identified genome sequences, and applies the biological samples to the microarrays. The client receives the results of the analysis over the Internet. The genomics services provided include genotyping, gene expression, and proteomics. The Client is able over the Internet to obtain the current status of the samples and the experiments and to modify the requested experiments based, for example, on the analysis of previously obtained results.

Abstract: Biological retrieval system employing a DNA biological specimen repository and robotic mechanism for automated retrieval and processing of the individual specimens. The DNA repository includes individual specimens which include an identification code readable by the robotic assembly and correlated with medical information about the individual whose specimen is on file. The medical information is housed within a database. Upon request, a population sample is determined from the database and the robotic system retrieves particular specimens for subsequent processing. Selected specimens are delivered to a first staging area. At that point, a feeder assembly relocates the biological specimens to a second staging area for punching by a punch head assembly. The punch head assembly moves each pellet or punched sample to a predetermined location, such as for example, a single well of a multiwell tray for subsequent biological processing.

Abstract: The invention relates to kits and methods for hybridizing nucleic acids with a specific nucleic acid-binding agent, such as a complementary nucleic acid. Previously, others have hybridized a nucleic acid with such an agent bound to a substrate. The improved methods described herein comprise binding a polycationizable attractor compound to the substrate, in addition to the agent. Examples of suitable polycationizable attractor compounds include polypeptides, including those with tunable cationizable amino acid residues, such as histidine. Compositions, kits, devices, and methods that make use of this hybridization rate enhancement technology are disclosed.

Abstract: The invention provides methods for preparing a reaction substrate for use as assay devices comprising parallel printing of arrays of biosites on reaction substrates, wherein each biosite comprises a single type of capture probe bound to the reaction substrate and the array of biosites is deposited on the reaction substrate by a capillary bundle printer device.