Patents Assigned to Genomic Solutions, Inc.
-
Patent number: 7488604Abstract: The present invention comprises a removable capillary tip insert which provides for replacement of an individual capillary in the dispensing head of an automated liquid handling apparatus. In some embodiments, the insert has been designed to accept variable capillary lengths while maintaining a constant length protruding from the insert. In a preferred embodiment, the removable capillary insert of the invention comprises a head adapted to accept an insertion tool and tapered to seat in the dispense head; a shaft with external threads which form a threaded collar that permits the insert to be screwed into the dispense head; a lumen running internally from the proximal to the distal ends of the head and shaft which forms a hollow interior in the insert in which a capillary resides; and a capillary tube of user-selected liquid capacity. One embodiment, without limitation, comprises a molded plastic part with an integral capillary tube.Type: GrantFiled: July 12, 2004Date of Patent: February 10, 2009Assignee: Genomic Solutions Inc.Inventors: Jay Clark, Carl Churchill
-
Publication number: 20050112776Abstract: The present invention comprises a removable capillary tip insert which provides for replacement of an individual capillary in the dispensing head of an automated liquid handling apparatus. In some embodiments, the insert has been designed to accept variable capillary lengths while maintaining a constant length protruding from the insert. In a preferred embodiment, the removable capillary insert of the invention comprises a head adapted to accept an insertion tool and tapered to seat in the dispense head; a shaft with external threads which form a threaded collar that permits the insert to be screwed into the dispense head; a lumen running internally from the proximal to the distal ends of the head and shaft which forms a hollow interior in the insert in which a capillary resides; and a capillary tube of user-selected liquid capacity. One embodiment, without limitation, comprises a molded plastic part with an integral capillary tube.Type: ApplicationFiled: July 12, 2004Publication date: May 26, 2005Applicant: Genomic Solutions Inc.Inventors: Jay Clark, Carl Churchill
-
Publication number: 20030108874Abstract: The invention comprises compositions and systems to identify and compare expressed genes in a given in vivo or in vitro RNA sample, as well as the relative difference in mRNA expression between two or more samples, where desired. Furthermore, the invention comprises compositions and systems to identify novel genes. The invention comprises, without limitation, one or more mRNA specific identimers for use in reverse transcription that themselves comprise an oligo-T nucleotide sequence (at the 5′ end) linked to a nucleotide sequence VNx (at the 3′ end) where the V nucleotide immediately adjacent to the oligo-T segment is not a T.Type: ApplicationFiled: November 1, 2001Publication date: June 12, 2003Applicant: Genomic Solutions, Inc.Inventors: Michael D. Kane, Aaron C. Nagel, Alan A. Dombkowski
-
Publication number: 20020192806Abstract: An apparatus for automatically hybridizing nucleic acid samples is disclosed. The apparatus includes a fluid control module and a temperature control module for precisely controlling fluid contacting and temperature of a plurality of DNA samples. The DNA samples are typically arrayed on solid substrates (glass microscope slides), and the disclosed apparatus can process up to twelve slides at one time on a master unit; satellite units can be added to increase the number of slides. All slides can be processed in parallel, or may be addressed individually to undergo different hybridization protocols. Thermal control is typically by slide pairs, such that each slide pair undergoes the same temperature profile. Processes are carried out under software control by an embedded PC (personal computer). User input is by touchscreen or floppy disk drive.Type: ApplicationFiled: July 22, 2002Publication date: December 19, 2002Applicant: Genomic Solutions, Inc.Inventors: Aaron Custance, Jonathan I. Parker
-
Patent number: 6496309Abstract: An automated CCD-based imaging system is disclosed which may be used for the automated acquisition, compilation, and analysis of images of fluorescently labeled samples of different types, including fluorescently-labeled gene chip arrays.Type: GrantFiled: June 16, 2000Date of Patent: December 17, 2002Assignee: Genomic Solutions, Inc.Inventors: Allison Christyne Bliton, Claus Werner Buchholz, Richard Lawrence Fisher, George Harold Byrkit, David Carter
-
Patent number: 6432696Abstract: An apparatus for automatically hybridizing nucleic acid samples is disclosed. The apparatus includes a fluid control module and a temperature control module for precisely controlling fluid contacting and temperature of a plurality of DNA samples. The DNA samples are typically arrayed on solid substrates (glass microscope slides), and the disclosed apparatus can process up to twelve slides at one time on a master unit; satellite units can be added to increase the number of slides. All slides can be processed in parallel, or may be addressed individually to undergo different hybridization protocols. Thermal control is typically by slide pairs, such that each slide pair undergoes the same temperature profile. Processes are carried out under software control by an embedded PC (personal computer). User input is by touchscreen, floppy disk drive, or external network control.Type: GrantFiled: May 14, 2001Date of Patent: August 13, 2002Assignee: Genomic Solutions, Inc.Inventors: Aaron Custance, Jonathan I. Parker
-
Publication number: 20010046700Abstract: An apparatus for automatically hybridizing nucleic acid samples is disclosed. The apparatus includes a fluid control module and a temperature control module for precisely controlling fluid contacting and temperature of a plurality of DNA samples. The DNA samples are typically arrayed on solid substrates (glass microscope slides), and the disclosed apparatus can process up to twelve slides at one time on a master unit; satellite units can be added to increase the number of slides. All slides can be processed in parallel, or may be addressed individually to undergo different hybridization protocols. Thermal control is typically by slide pairs, such that each slide pair undergoes the same temperature profile. Processes are carried out under software control by an embedded PC (personal computer). User input is by touchscreen or floppy disk drive.Type: ApplicationFiled: May 14, 2001Publication date: November 29, 2001Applicant: Genomic Solutions, Inc.Inventors: Aaron Custance, Jonathan I. Parker
-
Patent number: 6302159Abstract: An apparatus and method for chemical processing of multiple mixtures is disclosed. The apparatus provides selective purging of a liquid-phase of the mixtures. The apparatus can be used for processing many different types of mixtures under a wide variety of processing conditions, including but not limited to protein digestions, and is particularly well suited for processes requiring solid-liquid contacting. The apparatus includes an array of vessels or wells for containing the mixtures. The wells have openings that generally define a surface. A perforated plate and a film are disposed above the openings of the wells. The film is sandwiched between the perforated plate and the surface defined by the openings of the vessels, covering and sealing the vessels. A probe is used to perforate the film and to pressurize the vessels, which drives liquid out of the wells via through-holes formed in their bottoms.Type: GrantFiled: June 9, 2000Date of Patent: October 16, 2001Assignee: Genomic Solutions, Inc.Inventors: Paul Thomas Ryan, Kevin Auton
-
Patent number: 6238910Abstract: An apparatus for automatically hybridizing nucleic acid samples is disclosed. The apparatus includes a fluid control module and a temperature control module for precisely controlling fluid contacting and temperature of a plurality of DNA samples. The DNA samples are typically arrayed on solid substrates (glass microscope slides), and the disclosed apparatus can process up to twelve slides at one time on a master unit; satellite units can be added to increase the number of slides. All slides can be processed in parallel, or may be addressed individually to undergo different hybridization protocols. Thermal control is typically by slide pairs, such that each slide pair undergoes the same temperature profile. Processes are carried out under software control by an embedded PC (personal computer). User input is by touchscreen, floppy disk drive, or external network control.Type: GrantFiled: August 10, 1999Date of Patent: May 29, 2001Assignee: Genomic Solutions, Inc.Inventors: Aaron Custance, Jonathan I. Parker