Abstract: Novel diazepine derivatives which selectively inhibit adenosine monophosphate deaminase and methods of preparing these compounds are provided. These compounds are useful in treating certain conditions in vivo which may be ameliorated by increased local concentrations of adenosine.
Type:
Grant
Filed:
February 3, 1994
Date of Patent:
March 24, 1998
Assignee:
Gensia Sicor Inc.
Inventors:
Mark D. Erion, Brett C. Bookser, Srinivas Rao Kasibhatla, Harry E. Gruber