Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.

Abstract: Disclosures herein encompass methods of treating a subject with moderate to severe hidradenitis suppurativa (HS) encompassing the determination of differential gene expression to characterize HS severity followed by administration of a treatment specific for the stage of HS severity characterized in the subject.

Abstract: Metal nanoparticle-bearing carbonaceous supports, or solid-supported metal-catalysts, can be formed by incipient wetness, wet impregnation and ethylene glycol reduction methods. The solid-supported metal-catalysts can be used a heterogeneous catalysts in various catalytic reactions such as hydrodeoxygenation reactions, catalyze hydrodehalogenation reactions, N—N hydrogenolysis reactions and oxidation reactions. The solid-supported metal-catalysts are easy to handle, are easily separable from reaction media, are stable in various types of reaction media, and are recyclable.

Abstract: The present application relates to biocompatible polymers that exhibit a shape-memory effect, devices made using the materials and methods of producing such materials and devices.

Abstract: High quality flake graphite is produced by methods that include mixing a carbon-containing feedstock with a catalyst to form a feedstock/catalyst mixture, or coating a catalyst with a carbon-containing feedstock, and subjecting the mixture or feedstock-coated catalyst to irradiation with a laser to convert the feedstock into flake graphite in the presence of the catalyst. In some instances, the feedstock is converted to a char by pyrolysis and the char is instead subjected to laser irradiation. The feedstock can be a biomass or a carbonaceous material. The catalyst can be an elemental metal, an alloy, or a combination thereof. In some instances, methods described herein have been found to produce high quality flake graphite in the form of potato shaped agglomerates.

Abstract: The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising performing one or more assays configured to detect one or more biomarkers on a body fluid sample obtained from the subject to provide one or more assay result(s) and correlating the assay result(s) to the occurrence or nonoccurrence of appendicitis in the subject or likelihood of the future outcome to the subject.

Abstract: Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.

Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

Abstract: An accelerator for modern convolutional neural networks applies the Winograd filtering algorithm in a wavelength division multiplexing integrated photonics circuit modulated by a memristor-based analog memory unit.

Abstract: A multi-step method to produce materials, and coatings of materials, which has three key characteristics. The first is that the density of the resulting materials or coatings can be controllably and widely variable from less than ten percent of normal density up to normal density. The second key characteristic of the invention is the use of starting materials having powders that have grains (particles) with one, two or three dimensions on the size scales of nanometers or micrometers. The third major characteristic part of the invention is the use of microwave radiation or induction heating to quickly raise the temperature of the powders to produce materials or coatings before deleterious diffusion and densification can occur. These features produce new types of materials with properties favorable to many applications, such as chemical and other catalysis, electrolysis in batteries and fuel cells, and light weight structural components.

Abstract: A photonic waveguide assembly has a first arm comprising a first photonic waveguide transmitting a first light, an optical refractive index modulator positioned about said first photonic waveguide to modulate the phase or amplitude, or combination thereof of the first light traveling in the first photonic waveguide; a second arm comprising a second photonic waveguide transmitting a second light; and a passive contact that contacts at least a portion of the second photonic waveguide of said second arm.

Abstract: An accelerator for modern convolutional neural networks applies the Winograd filtering algorithm in a wavelength division multiplexing integrated photonics circuit modulated by a memristor-based analog memory unit.

Abstract: A digital-to-analog converter has a first interface coupled to a second interface through one or more modulation circuits. The circuits include a first coupler connected to the first interface; a first waveguide with a first lead connected to the first coupler, a first end, and a first length running therebetween. The first lead and the first end are coupled by a first switch. The circuits also include: a second coupler connected to the first interface; a second waveguide having a second lead connected to the second coupler, a second end, and a second length running therebetween, the second lead and the second end coupled by a second switch along the second length; and an optical combiner connected to the ends of the waveguides. The second interface is connected to the optical combiner of the modulation circuits. Output from the second interface is an optical signal capable of carrying binary information.

Abstract: Biphasic tissue constructs that include a scaffold having one or more channels, a vascular portion comprising a hydrogel at least partially disposed in the one or more channels, and a first bioactive growth factor and a second bioactive growth factor different from the first bioactive growth factor, the first bioactive growth factor localized to the scaffold and the second bioactive growth factor localized to the vascular portion. The first bioactive growth factor may be bone morphogenetic protein 2 (BMP2) peptide and the second bioactive growth factor may be vascular endothelial growth factor (VEGF) peptide.

Abstract: A device employing the generation and enhancement of surface acoustic waves on a highly doped p-type III-V semiconductor substrate (e.g., GaAs, GaSb, InAs, or InGaAs). The device includes two SiO2/ZnO islands, each including a SiO2 buffer layer deposited on the doped p-type III-V semiconductor substrate and a ZnO layer deposited on the SiO2 buffer layer. An input interdigital transducers (IDT) and an output IDT are each patterned on one of the SiO2/ZnO islands. The IDTs generates surface acoustic waves along an exposed surface of the highly doped p-type III-V semiconductor substrate. The surface acoustic waves improve the photoelectric and photovoltaic properties of the device. The device is manufactured using a disclosed technique for propagating strong surface acoustic waves on weak piezoelectric materials. Also disclosed is a photodetector developed using that technique.

Abstract: The present disclosure provides methods, pharmaceutical compositions, dosing regimens, and kits comprising 4,4?-trans-dihydroxystilbene (DHS), including methods of treating cancer in a subject and methods of decreasing or reversing resistance to a DNA damaging agent in a subject.

Abstract: The present disclosure relates to an improved process for the synthesis of nanomaterials and composites from Zintl phases. The nanomaterials and composites are useful, for example, as ion storage materials.

Abstract: A linear regulator operates in the manner of a linear voltage regulator, but with the functionality of a switching converter. This concept enables DC voltage up-conversion with no switching, more efficient step down of large voltage steps, and requires no expensive and bulky additional components. An optocoupler device transfers power between light emitting and photovoltaic devices.

Abstract: The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.

Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are ?,?-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.