Abstract: One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas sequestration. Another aspect of the present invention relates to a class of solvents which can be transformed into RTILs by exposure to a gas, and methods of using them in connection with temporary or permanent gas sequestration.
Type:
Application
Filed:
January 28, 2008
Publication date:
March 31, 2011
Applicant:
Georgetown University Office of Technology commercialization
Inventors:
Tao Yu, Richard G. Weiss, Taisuke Yamada, Mathew George
Abstract: The present invention relates to substituted cytisine compounds that are useful in treating diseases impacted by a nicotinic ACh receptor. One aspect of the invention relates to 10-substituted cytisine compounds. In certain instances, the cytisine is substituted in the 10-position by an alkyl, aryl or aralkyl group. The present invention also relates to a pharmaceutical composition comprises the substituted cytisine compound or the 10-substituted cytisine compound. The invention also relates to a method of modulation a nicotinic ACh receptor in a mammal, comprising the step of administering to a mammal in need thereof a therapeutically effective amount of a substituted cytisine. In certain instances, the substituted cytisine is a 10-substituted cytisine. Another aspect of the present invention relates a method of treating a disease impacted by a nicotinic ACh receptor, comprising the step of administering to a mammal in need thereof a therapeutically effective amount of a substituted cytisine.
Type:
Application
Filed:
March 29, 2007
Publication date:
February 25, 2010
Applicant:
Georgetown University Office of Technology Commercialization
Inventors:
Alan P. Kozikowski, Werner Tueckmantel, Sheela Chellappan, Kenneth J. Kellar, Yingxian Xiao