Patents Assigned to Gilead Sciences, Inc.
  • Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof
    Patent number: 11548871
    Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH).
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: January 10, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Brian P. Bestvater, Zhimin Du, Julie Farand, Gregory Notte, Barton W. Phillips, Doris T. Tang, Chandrasekar Venkataramani, Peiyuan Wang, Kin S. Yang, Anna Zagorska
  • Substituted 1,4-methanopyrido[1?,2?:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections
    Patent number: 11548901
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: January 10, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Elizabeth M. Bacon, Zhenhong R. Cai, Xiaowu Chen, Jeromy J. Cottell, Manoj C. Desai, Mingzhe Ji, Haolun Jin, Scott E. Lazerwith, Michael R. Mish, Philip Anthony Morganelli, Hyung-Jung Pyun, James G. Taylor, Teresa Alejandra Trejo Martin
  • Pyrrolo[1,2-b] pyridazine derivatives
    Patent number: 11535622
    Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: December 27, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Stephen Ammann, Elizabeth M. Bacon, Gediminas Brizgys, Elbert Chin, Chienhung Chou, Jeromy J. Cottell, Marilyn Ndukwe, James G. Taylor, Nathan E. Wright, Zheng-Yu Yang, Sheila M. Zipfel
  • Solid forms of FXR agonists
    Patent number: 11524005
    Abstract: Disclosed herein are novel solid forms of FXR agonists. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by FXR. The disclosure also relates to methods for obtaining such solid forms.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: December 13, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Derek M. Dalton, Peter C. Fung, Nolan Griggs, Jeffrey N. Hemenway, Olga V. Lapina, Matthew M. Logan, Sean T. Neville, Bryan J. Reynolds, Hui-Wen Shih, Anna M. Wagner
  • HBV vaccines and methods treating HBV
    Patent number: 11497808
    Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: November 15, 2022
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Scott J. Balsitis, Sarah M. Ahmadi-Erber, Timo Schippers, Sarah Schmidt
  • Methods and compounds for treating virus infections
    Patent number: 11492353
    Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: November 8, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Richard L. Mackman, Jay P. Parrish, Adrian S. Ray, Dorothy Agnes Theodore
  • Remdesivir treatment methods
    Patent number: 11491169
    Abstract: Provided herein are methods of treating or preventing a viral infection in a subject comprising administering a compound of Formula I, Formula Ia, or Formula Ib, or a pharmaceutically acceptable salt thereof, wherein the subject is not being treated with chloroquine, or an analog or salt thereof.
    Type: Grant
    Filed: February 22, 2022
    Date of Patent: November 8, 2022
    Assignee: Gilead Sciences, Inc.
    Inventor: Tomas Cihlar
  • Substituted eneoxindoles and uses thereof
    Patent number: 11453681
    Abstract: The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: September 27, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Evangelos Aktoudianakis, Jayaraman Chandrasekhar, Julian A. Codelli, John H. Conway, Kristyna M. Elbel, Rao V. Kalla, Samuel E. Metobo, Scott A. Mitchell, Thao D. Perry, Scott P. Simonovich, Christopher A. Ziebenhaus
  • Crystalline forms of tenofovir alafenamide
    Patent number: 11440928
    Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: September 13, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Chiajen Lai, Bing Shi, Robert G. Strickley
  • Methods and compounds for treating virus infections
    Patent number: 11420972
    Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: August 23, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Richard L. Mackman, Jay P. Parrish, Adrian S. Ray, Dorothy Agnes Theodore
  • Substituted pyrrolizine compounds and uses thereof
    Patent number: 11420974
    Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: August 23, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: David Alan Gutierrez, Tetsuya Kobayashi, Scott E. Lazerwith, Rick Andrew Lee, Philip Anthony Morganelli, Hyung-Jung Pyun
  • Solid forms of a toll-like receptor modulator
    Patent number: 11396509
    Abstract: The present disclosure provides solid forms, solvates and hydrates of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol, and methods of making.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: July 26, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Sylvie M. Asselin, Henry G. Morrison
  • Methods for treating and virus infections
    Patent number: 11382926
    Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: July 12, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Michael O'Neil Hanrahan Clarke, Joy Yang Feng, Robert Jordan, Richard L. Mackman, Adrian S. Ray, Dustin Siegel
  • Pharmaceutical package
    Patent number: D955215
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: June 21, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Benjamin Luke Kozub, Brian Nilstoft, Kevin Nguyen, James Paul Oberhauser, Roman Shumylo, Joseph Anthony Cordova, Jinhui Yun, William Harold Lizor, Adam Hilborn, Jesse Arnold Fourt, Léo Boris Marzolf, Pratap Uday Ganapathy, Brooke Genelle Thyng, Caricia Catalani, Soizic Porhel, Jose Angel Meza, Steven M. Scally, Mary Cassandra Lodwick
  • Pharmaceutical package
    Patent number: D958649
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: July 26, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Benjamin Luke Kozub, Brian Nilstoft, Kevin Nguyen, James Paul Oberhauser, Roman Shumylo, Joseph Anthony Cordova, Jinhui Yun, William Harold Lizor, Adam Hilborn, Jesse Arnold Fourt, Léo Boris Marzolf, Pratap Uday Ganapathy, Brooke Genelle Thyng, Caricia Catalani, Soizic Porhel, Jose Angel Meza, Steven M. Scally, Mary Cassandra Lodwick
  • Pharmaceutical package
    Patent number: D958652
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: July 26, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Benjamin Luke Kozub, Brian Nilstoft, Kevin Nguyen, James Paul Oberhauser, Roman Shumylo, Joseph Anthony Cordova, Jinhui Yun, William Harold Lizor, Adam Hilborn, Jesse Arnold Fourt, Léo Boris Marzolf, Pratap Uday Ganapathy, Brooke Genelle Thyng, Caricia Catalani, Soizic Porhel, Jose Angel Meza, Steven M. Scally, Mary Cassandra Lodwick
  • Blister pack
    Patent number: D960718
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: August 16, 2022
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Robert Bridges, Joseph Cordova, Trevor Zimmermann, Caricia Catalani, Kangil Cheon, Hortense Caroline Agnes Desodt, Jesse Arnold Fourt, Brittany Jeannette Margot
  • Blister pack
    Patent number: D961406
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: August 23, 2022
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Robert Bridges, Joseph Cordova, Trevor Zimmermann, Caricia Catalani, Kangil Cheon, Hortense Caroline Agnes Desodt, Jesse Arnold Fourt, Brittany Jeannette Margot
  • Blister pack
    Patent number: D973511
    Type: Grant
    Filed: July 6, 2022
    Date of Patent: December 27, 2022
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Robert Bridges, Joseph Cordova, Trevor Zimmermann, Caricia Catalani, Kangil Cheon, Hortense Caroline Agnes Desodt, Jesse Arnold Fourt, Brittany Jeannette Margot
  • Blister pack
    Patent number: D973512
    Type: Grant
    Filed: July 6, 2022
    Date of Patent: December 27, 2022
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Robert Bridges, Joseph Cordova, Trevor Zimmermann, Caricia Catalani, Kangil Cheon, Hortense Caroline Agnes Desodt, Jesse Arnold Fourt, Brittany Jeannette Margot