Patents Assigned to Giuliani S.p.A
  • Patent number: 11793792
    Abstract: The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: October 24, 2023
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Barbara Marzani, Daniela Pinto, Sergio Baroni, Ralf Paus, Nathan Hawkshaw
  • Patent number: 11759432
    Abstract: The present invention concerns the use of selected compounds in a cosmetic skincare treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceutically or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: September 19, 2023
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Ralf Paus, Jeremy Cheret, Barbara Marzani, Sergio Baroni
  • Patent number: 11273193
    Abstract: The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: March 15, 2022
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Ralf Paus, Benedetto Grimaldi, Barbara Marzani, Sergio Baroni
  • Patent number: 10898419
    Abstract: The invention concerns the use of compounds of general formula (I): (I) wherein: R1 and R2 form together a double bond, or R1 and R2 form together a cyclopropyl group; R3, R4 are the same or different and independently chosen from hydrogen, methyl, or R3 and R4 form together a double bond; R5, R6 are the same or different and independently chosen from hydrogen, methyl; or R5 and R6 form together a double bond, or R5 and R6 form together a cyclopropyl group; R7=methyl, or ethyl; R8=hydrogen, or methyl, for promoting hair growth and/or inhibiting or delaying hair loss in the human scalp, and cosmetic and pharmaceutical compositions suitable for such use.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: January 26, 2021
    Assignee: GIULIANI S.P.A.
    Inventors: Ralf Paus, Jeremy Cheret, Hanns Hatt, Sergio Baroni
  • Patent number: 10675239
    Abstract: The present invention relates to the use of a plant extract from the genus Galeopsis species tetrahit or a composition that contains it to stimulate hair growth or improve the appearance or hair fullness. The composition containing the plant extract is applied in both cosmetic and medical-trichological fields and can be applied topically on the scalp or administered orally.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: June 9, 2020
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Barbara Marzani
  • Patent number: 10278909
    Abstract: The present invention relates to a composition for pharmaceutical, nutritional or cosmetic use, suitable to preserve the physiological condition and health of skin and hair and to reestablish their regenerative functions, characterized in that it comprises a mixture of carnitine, caffeine and arginine as active principle, as such or as derivatives, such as pharmacologically acceptable salts. The effect of preserving the physiologic condition and health of skin and hair, and of reestablishing their regenerative functions is mainly achieved through an increase in ATP production by skin and hair cells.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: May 7, 2019
    Assignee: Giuliani S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Barbara Marzani, Antonio Mascolo, Antonio Limitone
  • Patent number: 10240139
    Abstract: The present invention concerns the use of lactic acid bacteria selected and fungal enzymes for the gluten complete degradation from both bread and durum wheat, barley, rye and oat flour. In particular, the invention concerns the use of lactic acid bacteria selected and fungal enzymes for the gluten complete degradation (residual gluten concentration lower than 20 ppm) of cereal flours, which after detoxification can be used according to a standardized biotechnological protocol for the production of various gluten-free foods.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: March 26, 2019
    Assignee: Giuliani S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Raffaella Di Cagno, Carlo Giuseppe Rizzello, Maria De Angelis, Marco Gobbetti, Angela Cassone
  • Patent number: 9944591
    Abstract: The invention relates to the 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid; its use in the therapeutic and cosmetic field for topical application to the skin to achieve a combined antioxidant activity against ROS together with an anti-inflammatory effect and an effect of promoting the production of hyaluronic acid, so as to oppose at the same time the oxidizing action of free radicals and inflammatory effects, in order to preserve the physiological conditions of human epidermis and skin homeostasis and prevent skin aging (anti-aging); the compositions for therapeutic and cosmetic use which comprise 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid as active ingredient, formulated with excipients for topical use suitable for local administration on the skin.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: April 17, 2018
    Assignee: Giuliani S.p.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Barbara Marzani, Sergio Baroni, Elena Pini
  • Patent number: 9808498
    Abstract: The invention relates to a composition for pharmaceutical or nutritional or cosmetic use, formulated for oral or topical use and possessing antioxidant activity against free radicals, comprising: a) a Vitis vinifera seed, or seed and leaf, extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 6:1 to 3:1, respectively, or a?) a Vitis vinifera seed, or seed and leaf, extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 7:1 to 4:1, respectively, or a?) a mixture of Vitis vinifera extracts a) and a?), or a??) a mixture of catechin and quercetin in a molar ratio in a range from 7:1 to 3:1, respectively, together with b) an olive, Olea europaea L, leaf extract having a hydroxytyrosol content in a range from 1% to 30% by weight of the extract, or b?) hydroxytyrosol in an amount equal to that contained in the b) extract.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 7, 2017
    Assignee: Giuliani S.p.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Barbara Marzani, Antonio Mascolo, Antonio Limitone, Sergio Baroni
  • Patent number: 9738682
    Abstract: The invention relates to 2,4,6-octatrienoic acid derivative compounds having general formula (I) (CH3—CH?CH—CH?CH—CH?CH—CO—O—)n—R (I) consisting of esters wherein n=1, 2, 3 and wherein R is selected from alkyl, aryl or cycloalkyl of a polyol, phenol or phenolic acid; or consisting of a salt wherein n=1 and R=arginine, as active ingredients in a pharmaceutical or cosmetic composition having a combined antioxidant activity against free radicals together with an anti-inflammatory action.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: August 22, 2017
    Assignee: Giuliani S.p.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Barbara Marzani, Sergio Baroni, Elena Pini, Raffaella Gandolfi
  • Patent number: 9668984
    Abstract: The object of the present invention is the use of compounds designed to inhibit the activity of the enzyme 5?-reductase. This is a novel use of compounds of general formula (I): CH3(—CH?CH)n—R??(I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R?, CO—O(?), where R? is chosen from among H, and the alky from C1 to C22, each compound of general formula (I) being used as such or in mixtures with other compounds, as the active principle in a pharmaceutical or cosmetic composition designed to inhibit the action of the enzyme 5?-reductase, and of the pharmaceutical or cosmetic compositions deriving therefrom.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: June 6, 2017
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Sergio Baroni
  • Patent number: 9597295
    Abstract: The present invention relates to a novel use of compounds having the general formula (I): CH3(—CH?CH)n—R??(I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R?, CO—OR?, CO—O(?), where R? is chosen from among H, the alkyl from C1 to C22, each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: March 21, 2017
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Sergio Baroni
  • Patent number: 9560854
    Abstract: The present invention concerns a mixture of lactic bacteria for yeasting of gluten-free baked products. Particularly, the invention concerns the use of “natural yeast” based on selected lactic bacteria as yeasting agent for the production of gluten-free bread, with improved sensory and nutritional property, designed for celiac patients feeding.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: February 7, 2017
    Assignee: GIULIANI S.p.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Raffaella Di Cagno, Maria De Angelis, Antonella Luisi, Marco Gobbetti
  • Patent number: 9539191
    Abstract: The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.
    Type: Grant
    Filed: February 17, 2014
    Date of Patent: January 10, 2017
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Ralf Paus, Anna Benedusi, Barbara Marzani, Sergio Baroni
  • Patent number: 9498429
    Abstract: The present invention relates, in one aspect, to the use of a composition based on a vegetal extract of Galeopsis segetum Necker and of a physiologically acceptable carrier in the treatment or prevention of hair loss. The composition finds application in the field of trichology and may be applied topically on the scalp or administered orally.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: November 22, 2016
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Barbara Marzani
  • Publication number: 20160213635
    Abstract: The invention relates to compounds of general formula (I): CH3—(CH?CH)n—R (I) wherein n=3, 5, 7; R is selected from —CO—OR?, —CO—O(?), or —CH2—O—CO—R?, R? being selected from H, C1-C22 alkyl or alkenyl.aryl or aralkyl, or sugars; with the proviso that when R is —CH2—O—CO—R? and R? alkyl, said alkyl being selected from C1 to C11; and pharmaceutically acceptable salts thereof, preferably such as sodium, potassium, lysine salts, each compound of general formula (I) being used as such or in admixture with one or more of the other ones, for use in the prevention or treatment of skin cancer resulting from DNA damage produced by UV radiation.
    Type: Application
    Filed: September 3, 2014
    Publication date: July 28, 2016
    Applicant: Giuliani S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Barbara Marzani, Sergio Baroni, Mauro Picardo
  • Patent number: 9394335
    Abstract: An ester of glycyrrhetinic acid with (poly)glycerol-sorbitol and cosmetic compositions thereof is described. The introduction of sorbitol in the (poly)glycerol chain determines an increase in solubility of the ester of the invention increasing solubility in water and the possibility of using glycyrrhetinic acid in cosmetic applications.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 19, 2016
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Guido Bregaglio, Antonio Mascolo
  • Patent number: 9386777
    Abstract: The present invention concerns the use of lactic acid bacteria selected and fungal enzymes for the gluten complete degradation from both bread and durum wheat, barley, rye and oat flour. In particular, the invention concerns the use of lactic acid bacteria selected and fungal enzymes for the gluten complete degradation (residual gluten concentration lower than 20 ppm) of cereal flours, which after detoxification can be used according to a standardized biotechnological protocol for the production of various gluten-free foods.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: July 12, 2016
    Assignee: Giuliani S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Raffaella Di Cagno, Carlo Giuseppe Rizzello, Maria De Angelis, Marco Gobbetti, Angela Cassone
  • Patent number: 9351918
    Abstract: A polyglycerol-azelaic acid polyesters and cosmetic compositions that incorporate them as active components in combination with a cosmetically acceptable vehicle. A process for producing esters and polyesters between azelaic acid and glycerol or oligomers thereof containing up to 10 monomer units.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: May 31, 2016
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Antonio Mascolo, Barbara Marzani, Guido Bregaglio
  • Patent number: 9289405
    Abstract: The invention relates to the use of compounds of general formula (I): CH3(—CH?CH)3—R??(I) wherein R is selected from CO—O—R? or CO—O(?), R? being selected from H, alkyl or alkenyl from C1 to C22, or sugars, and their pharmaceutically acceptable salts, preferably such as sodium, potassium, or lysine salts, each compound of general formula (I) being used as such or mixed with one or more of the others, as active ingredients in a pharmaceutical or cosmetic composition provided with antioxidant activity against free radicals.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: March 22, 2016
    Assignee: GIULIANI S.P.A
    Inventors: Giammaria Giuliani, Anna Benedusi