Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.
Type:
Grant
Filed:
April 5, 2018
Date of Patent:
February 9, 2021
Assignees:
The United States of America, as represented by the Secretary, Department of Health and Human Services, GLG Pharma, LLC, MRIGlobal
Inventors:
Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta
Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.
Type:
Application
Filed:
April 5, 2018
Publication date:
April 9, 2020
Applicants:
The United States of America,as represented by the Secretary,Department of Health and Human Services, GLG Pharma, LLC, MRIGlobal
Inventors:
Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta