Patents Assigned to GLOBAL BIOENERGIES
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Publication number: 20180363010Abstract: Describes is a fermentation method for producing a hydrocarbon compound comprising the culturing of an organism in a liquid fermentation medium, wherein said organism produces a desired hydrocarbon compound by an enzymatic pathway, said enzymatic pathway comprising an intermediate which evaporates into the gaseous phase and wherein said intermediate is recovered from the gaseous phase and is reintroduced into the liquid fermentation medium.Type: ApplicationFiled: August 7, 2018Publication date: December 20, 2018Applicant: Global BioenergiesInventor: Richard Bockrath
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Patent number: 10113186Abstract: Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of prenol into isoprene, methods for the production of isoprene using such enzyme variants and their uses in the production of isoprene from prenol.Type: GrantFiled: November 12, 2015Date of Patent: October 30, 2018Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Sabine Mazaleyrat, Marc Delcourt, Philippe Marlière
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Publication number: 20180223266Abstract: Described are HIV kinase variants showing an improved activity in converting 3-hydroxyisovalerate (HIV) into 3-phosphonoxyisovalerate (PIV), methods for the production of PIV using such enzyme variants as well as methods for the production isobutene in a subsequent reaction.Type: ApplicationFiled: July 27, 2016Publication date: August 9, 2018Applicants: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Sabine Mazaleyrat, Jean-Baptiste Barbaroux, Marc Delcourt, Francois Stricher, Philippe Marlière
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Patent number: 10036003Abstract: Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of a compound corresponding to the general formula CnH2nO into CnH2n-2 +H2O with 3<n<7. In particular, described are alkenol dehydratase variants having, e.g., an improved activity in converting but-2-en-1-ol (crotyl alcohol) into 1,3 butadiene and/or an improved activity in converting but-3-en-2-ol into 1,3 butadiene and/or an improved activity in converting 3-methylbut-2-en-1-ol (prenol) or 3-methylbut-3-en-2-ol (isoprenol) into isoprene and/or an improved activity in converting 2,3-dimethyl-but-2-en-1-ol into dimethyl-butadiene.Type: GrantFiled: May 16, 2014Date of Patent: July 31, 2018Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Philippe Marliere, Marc Delcourt, Sabine Mazaleyrat
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Patent number: 10017787Abstract: The application describes a method for producing alkenes (for example propylene, ethylene, 1-butylene, isobutylene, isoamylene, butadiene or isoprene) from 3-hydroxycarboxylic acids via 3-hydroxycarboxyl-nucleotidylic acids.Type: GrantFiled: December 2, 2014Date of Patent: July 10, 2018Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Maria Anissimova, Mathieu Allard, Philippe Marliere
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Patent number: 9879286Abstract: Described is a method for generating isoprenol through a biological process. More specifically, described is a method for producing isoprenol from mevalonate.Type: GrantFiled: April 4, 2013Date of Patent: January 30, 2018Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Marc Delcourt, Maria Anissimova, Philippe Marliere
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Patent number: 9850504Abstract: Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene.Type: GrantFiled: July 2, 2014Date of Patent: December 26, 2017Assignees: Scientist of Fortune, S.A., Global BioenergiesInventors: Philippe Marliere, Maria Anissimova, Mathieu Allard
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Publication number: 20170321229Abstract: Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of prenol into isoprene, methods for the production of isoprene using such enzyme variants and their uses in the production of isoprene from prenol.Type: ApplicationFiled: November 12, 2015Publication date: November 9, 2017Applicants: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Sabine MAZALEYRAT, Marc DELCOURT, Philippe MARLIÈRE
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Patent number: 9803220Abstract: The application describes a method for producing alkenes (for example propylene, ethylene, 1-butylene, isobutylene, isoamylene, butadiene or isoprene) from 3-hydroxy-1-carboxylic acids via 3-sulfonyloxy-1-carboxylic acids.Type: GrantFiled: October 24, 2013Date of Patent: October 31, 2017Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Philippe Marliere, Maria Anissimova, Mathieu Allard
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Publication number: 20170283809Abstract: Disclosed is a recombinant microorganism comprising endogenous enzymes that convert CO and/or CO2 to acetyl-CoA. The recombinant microorganism contains a heterologous nucleic acid sequence encoding one or more enzymes that allow the conversion of acetyl-CoA to an alkene with a main chain of 1 to 5 carbon atoms. The heterologous nucleic acid sequence comprises one or more coding sequences encoding one or more enzymes that catalyse the conversion of acetyl-CoA to crotonyl-CoA, and that further catalyse the conversion of crotonyl-CoA to an alkene; or one or more coding sequences encoding one or more enzymes that catalyse the conversion of acetyl-CoA to 3-methylcrotonyl-CoA, and that further catalyse the conversion of 3-methylcrotonyl-CoA to an alkene; or one or more coding sequences encoding one or more enzymes that catalyse the conversion of acetyl-CoA to propionyl-CoA, and that further catalyse the conversion of propionyl-CoA to an alkene.Type: ApplicationFiled: September 3, 2015Publication date: October 5, 2017Applicant: Global BioenergiesInventor: Bernhard GÜNTNER
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Publication number: 20170260548Abstract: Described is a method for the production of isobutene from 3-methylcrotonyl-CoA comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyric acid; and (b) further enzymatically converting the thus produced 3-methylbutyric acid into isobutene. The conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyryl-CoA and further enzymatically converting the thus produced 3-methylbutyryl-CoA into 3-methylbutyric acid. Alternatively, the conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3-methylcrotonyl-CoA into 3-methylcrotonic acid and then further enzymatically converting the thus produced 3-methylcrotonic acid into 3-methylbutyric acid.Type: ApplicationFiled: September 16, 2015Publication date: September 14, 2017Applicants: Scientist of Fortune, S.A., Global BioenergiesInventors: Philippe Marlière, Mathieu Allard
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Publication number: 20170253896Abstract: Described is a method for the conversion of 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyric acid comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyryl-CoA; and (b) further enzymatically converting the thus produced 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid wherein the enzymatic conversion of 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid according to step (b) is achieved by first converting 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyryl phosphate and then subsequently converting the thus produced 3-hydroxy-3-methylbutyryl phosphate into 3-hydroxy-3-methylbutyric acid.Type: ApplicationFiled: September 16, 2015Publication date: September 7, 2017Applicants: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Philippe MARLIERE, Maria ANISSIMOVA, Mathieu ALLARD
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Patent number: 9752163Abstract: Described is a method for the enzymatic production of isoprenol using mevalonate as a substrate and enzymatically converting it by a decarboxylation step into isoprenol as well as the use of an enzyme which is capable of catalyzing the decarboxylation of mevalonate for the production of isoprenol from mevalonate. Furthermore described is the use of mevalonate as a starting material for the production of isoprenol in an enzymatically catalyzed reaction.Type: GrantFiled: July 7, 2015Date of Patent: September 5, 2017Assignees: Global Bioenergies, Scientist of Fortune SAInventors: Philippe Marliere, Maria Anissimova, Romain Chayot, Marc Delcourt
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Patent number: 9453244Abstract: The present invention relates to a method for producing a monoalkene comprising the step of enzymatically converting an alkyl monoester. The conversion preferably makes use of an enzyme which belongs to the group of terpene synthases or to the family of prenyltransferases. Moreover, the present invention relates to the use of a terpene synthase or of a prenyltransferase for enzymatically converting an alkyl monoester into a monoalkene.Type: GrantFiled: June 28, 2013Date of Patent: September 27, 2016Assignees: Global Bioenergies, Scientist of Fortune S.A.Inventors: Philippe Marlière, Maria Anissimova, Mathieu Allard
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Patent number: 9193978Abstract: The present invention relates to a method for generating alkenes through a biological process. More specifically, the invention relates to a method for producing alkenes (for example propylene, ethylene, 1-butylene, isobutylene or isoamylene) from molecules of the 3-hydroxyalkanoate type.Type: GrantFiled: October 18, 2011Date of Patent: November 24, 2015Assignees: Scientist of Fortune, S.A., Global BioenergiesInventors: Marc Delcourt, Maria Anissimova, Richard Tallon, Philippe Marlière
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Patent number: 9102952Abstract: Described is a method for the enzymatic production of isoprenol using mevalonate as a substrate and enzymatically converting it by a decarboxylation step into isoprenol as well as the use of an enzyme which is capable of catalyzing the decarboxylation of mevalonate for the production of isoprenol from mevalonate. Furthermore described is the use of mevalonate as a starting material for the production of isoprenol in an enzymatically catalyzed reaction.Type: GrantFiled: December 22, 2009Date of Patent: August 11, 2015Assignees: Global Bioenergies SA, Scientist of FortuneInventors: Philippe Marliere, Maria Anissimova, Romain Chayot, Marc Delcourt
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Publication number: 20150159177Abstract: The present invention relates to a method for producing a monoalkene comprising the step of enzymatically converting an alkyl monoester. The conversion preferably makes use of an enzyme which belongs to the group of terpene synthases or to the family of prenyltransferases. Moreover, the present invention relates to the use of a terpene synthase or of a prenyltransferase for enzymatically converting an alkyl monoester into a monoalkene.Type: ApplicationFiled: June 28, 2013Publication date: June 11, 2015Applicants: GLOBAL BIOENERGIES, SCIENTIST OF FORTUNE S.A.Inventors: Philippe Marlière, Maria Anissimova, Mathieu Allard