Abstract: In a lateral flow test (LFT) device, the liquid conduit element 20 is formed from a substrate 21, 22 or 24 having at least two layers, including a first layer 21b, 22b or 24b not exceeding 75 ?m in thickness formed from a porous material for wicking liquid, and a second layer 21a,22a or 24a of additional thickness formed from a generally non-porous polymer material acting as backing layer. The layered arrangement is incorporated into an LFT device to reduce sample volume requirements.
Type:
Grant
Filed:
March 17, 2015
Date of Patent:
July 27, 2021
Assignee:
Global Life Sciences Solutions Germany GmbH
Inventors:
Alexander Schenk, Klaus Hochleitner, Suzana Kiel, Marcel Thieme, Wei Sun
Abstract: Disclosed is a method and apparatus for manufacturing a continuous web of polymeric membrane and for continuous downstream processing of said web. The apparatus (10) comprises: a casting station (20) for casting the continuous web (M); a carrier (24) for carrying the web downstream; a membrane drier (30) downstream of the carrier, for drying the web; and a brushing station (40) downstream of the drier for brushing the web. Said drier is located immediately downstream of the carrier, and upstream of said brushing station. The apparatus (10) further includes an additional drying station (50) downstream of the brushing station (40). Brushing after drying retains more surfactant in the membrane which is useful for certain applications. In addition, initial drying eliminates virtually all solvents from the membrane, but leaves some non-solvent (e.g. water) within it, which in turn fixes the surfactant on the nitrocellulose fibers, which improves significantly the consistency and reproducibility of the membrane.
Type:
Grant
Filed:
March 24, 2016
Date of Patent:
December 22, 2020
Assignee:
Global Life Sciences Solutions Germany GmbH
Inventors:
Marcel Thieme, Klaus Hochleitner, Suzana Kiel, Alexander Schenk, Wolfgang Thamm, Daniela Katarzynski, Georg Peter Danisch