Patents Assigned to GlobeImmune, Inc.
  • Yeast-brachyury immunotherapeutic compositions
    Patent number: 11944673
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: April 2, 2024
    Assignees: The USA, as represented by the Secretary, Dept. of Health and Human Services, GlobeImmune, Inc.
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Yeast-brachyury immunotherapeutic compositions
    Patent number: 11938175
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: March 26, 2024
    Assignees: The USA, as represented by the Secretary, Dept. of Health and Human Services, GlobeImmune, Inc.
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Combination immunotherapy compositions against cancer and methods
    Patent number: 11596675
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: March 7, 2023
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • Yeast-based immunotherapy and type I interferon sensitivity
    Patent number: 11304996
    Abstract: Disclosed are methods of treating individuals with yeast-based immunotherapy who have been preselected as being sensitive to type I interferons, as well as methods for selecting individuals for treatment with yeast-based immunotherapeutic compositions and methods for enhancing or improving an individual's response to yeast-based immunotherapy, based on the individual's sensitivity to type 1 interferons (T1IFNs).
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: April 19, 2022
    Assignees: The Regents of the University of Colorado, a body corporate, GlobeImmune, Inc.
    Inventors: Donald Bellgrau, Thomas H. King
  • Modified yeast-brachyury immunotherapeutic compositions
    Patent number: 11065313
    Abstract: Disclosed are improved yeast-based immunotherapeutic compositions comprising modified Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: July 20, 2021
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Thomas H. King, Zhimin Guo, Jeffrey Schlom, Claudia Palena
  • Yeast-MUC1 immunotherapeutic compositions and uses thereof
    Patent number: 11065318
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of mucin-1 (MUC1).
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: July 20, 2021
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Alex Franzusoff, Zhimin Guo, Jeffrey Schlom, Kwong-Yok Tsang
  • Combination immunotherapy compositions against cancer and methods
    Patent number: 10874729
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: December 29, 2020
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept of Health and Human Services
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
    Patent number: 10849971
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: December 1, 2020
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • Yeast-based immunotherapy and type I interferon sensitivity
    Patent number: 10799567
    Abstract: Disclosed are methods of treating individuals with yeast-based immunotherapy who have been preselected as being sensitive to type I interferons, as well as methods for selecting individuals for treatment with yeast-based immunotherapeutic compositions and methods for enhancing or improving an individual's response to yeast-based immunotherapy, based on the individual's sensitivity to type 1 interferons (T1IFNs).
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: October 13, 2020
    Assignees: GlobeImmune, Inc., The Regents of the University of Coloradio
    Inventors: Donald Bellgrau, Thomas H. King
  • Compositions and methods for the treatment or prevention of tuberculosis
    Patent number: 10722567
    Abstract: Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: July 28, 2020
    Assignees: GlobeImmune, Inc., Colorado State University Research Foundation
    Inventors: Thomas H. King, Zhimin Guo, Ian M. Orme
  • Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
    Patent number: 10593529
    Abstract: A method and system for predicting in advance of treatment whether a cancer patient is likely, or not likely, to obtain benefit from administration of a yeast-based immune response generating therapy, which may be yeast-based immunotherapy for mutated Ras-based cancer, alone or in combination with another anti-cancer therapy. The method uses mass spectrometry of a blood-derived patient sample and a computer configured as a classifier using a training set of class-labeled spectra from other cancer patients that either benefited or did not benefit from an immune response generating therapy alone or in combination with another anti-cancer therapy.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: March 17, 2020
    Assignees: Biodesix, Inc., GlobeImmune, Inc.
    Inventors: Joanna Röder, Heinrich Röder
  • Yeast-based immunotherapy for Chordoma
    Patent number: 10507235
    Abstract: One embodiment of the invention relates to a method to treat chordoma in an individual who has chordoma. The method includes the step of administering to an individual who has chordoma, an immunotherapeutic composition comprising: (a) a yeast vehicle; and (b) a cancer antigen comprising at least one Brachyury antigen. Another embodiment of the invention relates to the use of an immunotherapeutic composition comprising a yeast vehicle and a cancer antigen comprising at least one Brachyury antigen to chordoma in an individual who has chordoma. Yet another embodiment of the invention relates to the use an immunotherapeutic composition comprising a yeast vehicle.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: December 17, 2019
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Timothy C. Rodell, David Apelian, Claudia Palena, Jeffrey Schlom
  • Compositions and methods for the treatment or prevention of hepatitis B virus infection
    Patent number: 10441650
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: October 15, 2019
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • Combination immunotherapy compositions against cancer and methods
    Patent number: 10383924
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: August 20, 2019
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • Yeast-brachyury immunotherapeutic compositions
    Patent number: 10363294
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: July 30, 2019
    Assignees: GlobeImmune, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Claudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
  • Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
    Patent number: 10265393
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 23, 2019
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • Compositions and methods for the treatment or prevention of tuberculosis
    Patent number: 10226522
    Abstract: Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: March 12, 2019
    Assignees: GLOBEIMMUNE, INC., COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Thomas H. King, Zhimin Guo, Ian M. Orme
  • Yeast-MUC1 immunotherapeutic compositions and uses thereof
    Patent number: 10188714
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of mucin-1 (MUC1).
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: January 29, 2019
    Assignees: GlobeImmune, Inc., The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Alex Franzusoff, Zhimin Guo, Jeffrey Schlom, Kwong-Yok Tsang
  • Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection
    Patent number: 9987352
    Abstract: Disclosed are immunotherapeutic compositions and methods for preventing and/or treating hepatitis delta virus (HDV) infection, including yeast-based HDV immunotherapeutic compositions and methods of use of such compositions to prevent and/or treat HDV infection and symptoms and sequela thereof.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: June 5, 2018
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • Compositions and methods for the treatment or prevention of hepatitis B virus infection
    Patent number: 9943591
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: April 17, 2018
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott