Patents Assigned to Glycosyn LLC
  • Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides
    Patent number: 11643675
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: May 9, 2023
    Assignee: Glycosyn LLC
    Inventors: John M. McCoy, Matthew Ian Heidtman, Massimo Merighi
  • Microorganisms and methods for producing sialylated and n-acetylglucosamine-containing oligosaccharides
    Patent number: 11618912
    Abstract: The invention provides compositions and methods for engineering bacteria to produce sialylated and N-acetylglucosamine-containing oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: April 4, 2023
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, Matthew Ian Heidtman, John M. McCoy
  • Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides
    Patent number: 11453900
    Abstract: The invention relates to methods and compositions for the production of fucosylated oligosaccharides.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: September 27, 2022
    Assignee: GLYCOSYN LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Fucosylated oligosaccharides for prevention of coronavirus infection
    Patent number: 11331329
    Abstract: The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection and/or to promote recovery from a respiratory pathogen infection in the respiratory system and/or the GI tract of a subject.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: May 17, 2022
    Assignee: Glycosyn LLC
    Inventors: Ardythe L. Morrow, David S. Newburg, John M. McCoy
  • 2'-fucosyllactose for the prevention and treatment of coronavirus-induced inflammation
    Patent number: 11324766
    Abstract: The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection-induced host inflammation and/or to promote recovery from a respiratory pathogen infection-induced host inflammation in a subject.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: May 10, 2022
    Assignee: Glycosyn LLC
    Inventors: Ardythe L. Morrow, David S. Newburg, John M. McCoy
  • Sialyltransferases and uses thereof
    Patent number: 11274325
    Abstract: Provided herein, inter alia, are methods, bacteria, nucleic acids, and polypeptides for producing sialylated oligosaccharides.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: March 15, 2022
    Assignee: Glycosyn LLC
    Inventors: Srikrishnan Mallipeddi, Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
    Patent number: 11236376
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: February 1, 2022
    Assignee: Glycosyn LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides
    Patent number: 11046984
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: June 29, 2021
    Assignee: Glycosyn LLC
    Inventors: John M. McCoy, Matthew Ian Heidtman, Massimo Merighi
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 11028419
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: June 8, 2021
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 10815511
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: October 27, 2020
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 10487346
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 26, 2019
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Microorganisms and methods for producing sialylated and N-acetylglucosamine-containing oligosaccharides
    Patent number: 10415069
    Abstract: The invention provides compositions and methods for engineering bacteria to produce sialylated and N-acetylglucosamine-containing oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: September 17, 2019
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, Matthew Ian Heidtman, John M. McCoy
  • Use of purified 2?-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics
    Patent number: 10286001
    Abstract: The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: May 14, 2019
    Assignees: Glycosyn LLC, Trustees of Boston College
    Inventors: David S. Newburg, John M. McCoy, Massimo Merighi, Matthew Ian Heidtman, Zhuoteng Yu
  • Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
    Patent number: 10273516
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: April 30, 2019
    Assignee: Glycosyn LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 9970018
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: May 15, 2018
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Microorganisms and methods for producing sialylated and N-acetylglucosamine-containing oligosaccharides
    Patent number: 9758803
    Abstract: The invention provides compositions and methods for engineering bacteria to produce sialylated and N-acetylglucosamine-containing oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 12, 2017
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, Matthew Ian Heidtman, John M. McCoy
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 9587241
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: March 7, 2017
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Use of purified 2?-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics
    Patent number: 9567361
    Abstract: The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: February 14, 2017
    Assignees: Glycosyn LLC, Trustees of Boston College
    Inventors: David S Newburg, John M. McCoy, Massimo Merighi, Matthew Ian Heidtman, Zhuoteng Yu
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 9453230
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: September 27, 2016
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
    Patent number: 9029136
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: May 12, 2015
    Assignee: Glycosyn LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy