Patents Assigned to Good Start Genetics, Inc.
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Publication number: 20210292821Abstract: The invention generally relates to methods for determining aneuploidy of cells with respect to a control sample. In certain embodiments, the method involves exposing a sample to a plurality of probes capable of capturing DNA from at least one chromosome suspected of having an altered copy number, and at least one control DNA sample known or suspected to have a stable copy number, capturing and sequencing DNA that binds to the probes, calculating a chromosomal read fraction; determining a sample specific scaling factor; scaling the chromosomal read fractions, normalizing the scaled read fractions, and determining a copy number state of at least one chromosome.Type: ApplicationFiled: June 4, 2021Publication date: September 23, 2021Applicant: Good Start Genetics, Inc.Inventor: Athurva GORE
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Patent number: 11053548Abstract: The invention generally relates to methods for determining aneuploidy of cells with respect to a control sample. In certain embodiments, the method involves exposing a sample to a plurality of probes capable of capturing DNA from at least one chromosome suspected of having an altered copy number, and at least one control DNA sample known or suspected to have a stable copy number, capturing and sequencing DNA that binds to the probes, calculating a chromosomal read fraction; determining a sample specific scaling factor; scaling the chromosomal read fractions, normalizing the scaled read fractions, and determining a copy number state of at least one chromosome.Type: GrantFiled: May 12, 2015Date of Patent: July 6, 2021Assignee: Good Start Genetics, Inc.Inventor: Athurva Gore
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Patent number: 10851414Abstract: The invention generally relates to methods for determining carrier status with respect to a condition or disease. In certain embodiments, the method involves exposing a sample to a plurality of molecular inversion probes capable of capturing DNA from at least one genomic region suspected of having an altered copy number and at least one internal control DNA known or suspected to have a stable copy number, capturing and sequencing DNA that binds to the molecular inversion probes, and determining a copy number state of the at least one genomic region based on the sequence results.Type: GrantFiled: October 18, 2013Date of Patent: December 1, 2020Assignee: Good Start Genetics, Inc.Inventors: Eric D. Boyden, Gregory Porreca, Mark Umbarger
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Patent number: 10706017Abstract: The present invention generally relates to storing sequence read data. The invention can involve obtaining a plurality of sequence reads from a sample, identifying one or more sets of duplicative sequence reads within the plurality of sequence reads, and storing only one of the sequence reads from each set of duplicative sequence reads in a text file using nucleotide characters.Type: GrantFiled: January 3, 2017Date of Patent: July 7, 2020Assignee: Good Start Genetics, Inc.Inventors: Caleb J. Kennedy, Niru Chennagiri
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Patent number: 10445543Abstract: The invention generally relates to devices and systems for individually barcoding sample vessels. In certain embodiments, the devices comprise an attachment member and an extension member, where the extension member can accommodate an identifier, such as a barcode. When loaded into a substrate, the barcoded vials are scanned by a barcode reader.Type: GrantFiled: August 24, 2018Date of Patent: October 15, 2019Assignee: Good Start Genetics, Inc.Inventors: Gregory Porreca, Mark Umbarger, Athurva Gore
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Patent number: 10429399Abstract: The present disclosure describes a method of processing a biological sample. The method includes contacting the sample with a pH indicator that changes color in response to changes in pH. The presence of a pH indicator such as cresol red provides the benefit of improved visualization of the sample, verification that the sample is properly frozen and thawed, and increased precision in pH adjustments during the assay, among other benefits.Type: GrantFiled: September 18, 2015Date of Patent: October 1, 2019Assignee: Good Start Genetics, Inc.Inventor: Eric D. Boyden
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Patent number: 10066259Abstract: The invention relates to carrier screening and methods for describing a structural variant, such as a large rearrangement or chromosomal abnormality, in a person's genome using probes that are designed to determine the person's genetic sequence and reveal substitution mutations and small structural variants. Identifying a structural variant may include exposing a nucleic acid to a plurality of probes. Each probe has a linked pair of targeting arms designed to hybridize upstream and downstream of a target in a genome. The method includes hybridizing two of the probes to the nucleic acid and attaching the two probes together to create an inter-probe product as well as detecting the inter-probe product and reporting a structural variant of the genome in the nucleic acid.Type: GrantFiled: January 6, 2016Date of Patent: September 4, 2018Assignee: Good Start Genetics, Inc.Inventors: Athurva Gore, Mark Umbarger
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Patent number: 10061953Abstract: The invention generally relates to devices and systems for individually barcoding sample vessels. In certain embodiments, the devices comprise an attachment member and an extension member, where the extension member can accommodate an identifier, such as a barcode. When loaded into a substrate, the barcoded vials are scanned by a barcode reader.Type: GrantFiled: January 13, 2016Date of Patent: August 28, 2018Assignee: Good Start Genetics, Inc.Inventors: Gregory Porreca, Mark Umbarger, Athurva Gore
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Patent number: 9822409Abstract: The invention generally relates to methods for analyzing nucleic acids to identify novel mutations associated with diseases. In certain embodiments, methods of the invention involve obtaining nucleic acid from a subject having a disease, identifying at least one mutation in the nucleic acid, and comparing the mutation to a database of mutations known to be associated with the disease, wherein mutations that do not match to the database are identified as novel mutations.Type: GrantFiled: December 30, 2015Date of Patent: November 21, 2017Assignee: Good Start Genetics, Inc.Inventors: Caleb Kennedy, Mark Umbarger, Gregory Porreca
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Patent number: 9677124Abstract: The invention generally relates to methods for analyzing nucleic acids. In certain aspects, methods of the invention involve obtaining a sample including a nucleic acid template. A plurality of molecular inversion probes are tiled across a portion of the template. The probes are designed such that immediately adjacent probes hybridize to opposite strands of the nucleic acid template and probes on the same strand hybridize to the template in an overlapping manner. A region between targeting arms of a plurality of the molecular inversion probes is filled-in with nucleotides, and the filled-in region of a plurality of the probes is analyzed to obtain sequence information about the nucleic acid template.Type: GrantFiled: August 14, 2015Date of Patent: June 13, 2017Assignee: Good Start Genetics, Inc.Inventor: Mark Umbarger
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Patent number: 9535920Abstract: The present invention generally relates to storing sequence read data. The invention can involve obtaining a plurality of sequence reads from a sample, identifying one or more sets of duplicative sequence reads within the plurality of sequence reads, and storing only one of the sequence reads from each set of duplicative sequence reads in a text file using nucleotide characters.Type: GrantFiled: December 4, 2015Date of Patent: January 3, 2017Assignee: Good Start Genetics, Inc.Inventors: Caleb Kennedy, Niru Chennagiri
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Patent number: 9298804Abstract: The invention provides a system and method for describing polymorphisms or genetic variants based on information about mutations and relationships among them. The invention uses object-oriented concepts to describe variants as variant objects and relations among those variants as variant relation object, each object being an instance of an abstract class of genomic feature and able to contain any number of other objects. Information about genetic disorders is stored in association with the object that represents the pathogenic variant. Genetic test results are used to access corresponding objects to provide a report based on variants or polymorphisms in a patient's genetic material.Type: GrantFiled: July 11, 2014Date of Patent: March 29, 2016Assignee: Good Start Genetics, Inc.Inventors: Marcia M. Nizzari, Benjamin H. Breton, David L. Tefft, Xavier S. Haurie
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Patent number: 9292527Abstract: The present invention generally relates to storing sequence read data. The invention can involve obtaining a plurality of sequence reads from a sample, identifying one or more sets of duplicative sequence reads within the plurality of sequence reads, and storing only one of the sequence reads from each set of duplicative sequence reads in a text file using nucleotide characters.Type: GrantFiled: January 23, 2015Date of Patent: March 22, 2016Assignee: Good Start Genetics, Inc.Inventors: Caleb J. Kennedy, Niru Chennagiri
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Patent number: 9228233Abstract: The invention generally relates to methods for analyzing nucleic acids to identify novel mutations associated with diseases. In certain embodiments, methods of the invention involve obtaining nucleic acid from a subject having a disease, identifying at least one mutation in the nucleic acid, and comparing the mutation to a database of mutations known to be associated with the disease, wherein mutations that do not match to the database are identified as novel mutations.Type: GrantFiled: September 14, 2012Date of Patent: January 5, 2016Assignee: Good Start Genetics, Inc.Inventors: Caleb J. Kennedy, Mark Umbarger, Gregory Porreca
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Patent number: 9218352Abstract: The present invention generally relates to storing sequence read data. The invention can involve obtaining a plurality of sequence reads from a sample, identifying one or more sets of duplicative sequence reads within the plurality of sequence reads, and storing only one of the sequence reads from each set of duplicative sequence reads in a text file using nucleotide characters.Type: GrantFiled: January 23, 2015Date of Patent: December 22, 2015Assignee: Good Start Genetics, Inc.Inventors: Caleb J. Kennedy, Niru Chennagiri
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Patent number: 9163281Abstract: The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template.Type: GrantFiled: April 7, 2011Date of Patent: October 20, 2015Assignee: Good Start Genetics, Inc.Inventors: Gregory Porreca, Mark Umbarger, George Church
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Patent number: 9115387Abstract: The invention generally relates to methods for analyzing nucleic acids. In certain aspects, methods of the invention involve obtaining a sample including a nucleic acid template. A plurality of molecular inversion probes are tiled across a portion of the template. The probes are designed such that immediately adjacent probes hybridize to opposite strands of the nucleic acid template and probes on the same strand hybridize to the template in an overlapping manner. A region between targeting arms of a plurality of the molecular inversion probes is filled-in with nucleotides, and the filled-in region of a plurality of the probes is analyzed to obtain sequence information about the nucleic acid template.Type: GrantFiled: June 24, 2014Date of Patent: August 25, 2015Assignee: Good Start Genetics, Inc.Inventor: Mark Umbarger
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Publication number: 20150111203Abstract: The invention generally relates to methods for determining carrier status with respect to a condition or disease. In certain embodiments, the method involves exposing a sample to a plurality of molecular inversion probes capable of capturing DNA from at least one genomic region suspected of having an altered copy number and at least one internal control DNA known or suspected to have a stable copy number, capturing and sequencing DNA that binds to the molecular inversion probes, and determining a copy number state of the at least one genomic region based on the sequence results.Type: ApplicationFiled: October 18, 2013Publication date: April 23, 2015Applicant: GOOD START GENETICS, INC.Inventors: Eric D. Boyden, Gregory Porreca, Mark Umbarger
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Publication number: 20150111757Abstract: The invention generally relates to methods for determining carrier status with respect to a condition or disease. In certain embodiments, the method involves exposing a sample to a plurality of molecular inversion probes capable of capturing DNA from at least one genomic region suspected of having an altered copy number and at least one internal control DNA known or suspected to have a stable copy number, capturing and sequencing DNA that binds to the molecular inversion probes, and determining a copy number state of the at least one genomic region based on the sequence results.Type: ApplicationFiled: December 18, 2013Publication date: April 23, 2015Applicant: GOOD START GENETICS, INC.Inventors: Eric D. Boyden, Gregory Porreca, Mark Umbarger
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Patent number: D773070Type: GrantFiled: February 24, 2015Date of Patent: November 29, 2016Assignee: Good Start Genetics, Inc.Inventors: Gregory Porreca, Mark Umbarger, Athurva Gore