Abstract: The invention relates methods of identifying and predicting inter-patient differences in prognostic prediction for survival in androgen independent prostate cancer. It further related to methods for determining and exploiting such differences to improve medical outcomes. Moreover, it provides methods for determining if a subject has prostate cancer.
Type:
Application
Filed:
January 8, 2008
Publication date:
December 16, 2010
Applicant:
Government of the United States of America, as rep resented by the Secretary Dept. of Health and Hum
Inventors:
William D. Figg, Alex Sparreboom, Akinobu Hamada, Douglas K. Price, Tristan M. Sissung
Abstract: The present invention concerns the receptor for antiproliferative factor (APF) from bladder epithelial cells. In particular, there are compositions and methods for modulating APF, APF receptor, and/or the binding of APF to APF receptor. Agents that interfere with the binding of APF to its receptor or agents that enhance the binding of APF to its receptor are contemplated. In specific aspects, certain compositions are employed for a therapeutic purpose, such as interstitial cystitis or cancer, for example.
Type:
Application
Filed:
July 27, 2007
Publication date:
March 4, 2010
Applicants:
The University of Maryland, Baltimore, Government of the United States of America, as rep resented by the Secretary of the Dept. of Health
Inventors:
Susan K. Keay, Christopher Michejda, Gillian Tocci, Thomas Conrads, Timothy Veenstra, Brian Lewis Hood