Abstract: Methods and compositions are provided for determining a genotype associated with increased susceptibility to manic-depressive illness. The genotype is determined using markers for a region of chromosome 18 exhibiting linkage disequilibrium with manic-depressive illness. The invention also provides for a novel myo-inositol monophosphatase protein encoded for on chromosome 18.
Type:
Application
Filed:
September 19, 2002
Publication date:
September 11, 2003
Applicant:
The Government of the USA, the Secretary of the Department of Health and Human Services
Inventors:
Sevilla D. Detera-Wadleigh, Elliot S. Gershon, Judith A. Badner, Lynn R. Goldin, Wade H. Berrettini, Takeo Yoshikawa, Alan R. Sanders, Lisa E. Esterling
Abstract: Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.
Type:
Application
Filed:
January 7, 2003
Publication date:
August 7, 2003
Applicant:
Government of the USA, the Secretary Department of Health and Human Services
Inventors:
Joseph E. Saavedra, Larry K. Keefer, Aloka Srinivasan, Christian Bogdan, William G. Rice, Xinhua Ji