Abstract: Methods for diagnosis of autism spectrum disorders are described. Methods include culturing a cell sample of a test subject with a tryptophan-containing energy source and examining the culture to determine the ability of the cells of the test subject to properly metabolize tryptophan. A determination that a subject does not properly metabolize tryptophan is an indication that the subject may be afflicted with autism. Methods can be utilized as a quick and reliable diagnostic tool for autism spectrum disorders and may provide a unifying model for the genetic heterogeneity of autism spectrum disorders.

Abstract: Methods for diagnosis of autism spectrum disorders are described. Methods include culturing a cell sample of a test subject with a tryptophan-containing energy source and examining the culture to determine the ability of the cells of the test subject to properly metabolize tryptophan. A determination that a subject does not properly metabolize tryptophan is an indication that the subject may be afflicted with autism. Methods can be utilized as a quick and reliable diagnostic tool for autism spectrum disorders and may provide a unifying model for the genetic heterogeneity of autism spectrum disorders.

Abstract: The discovery that alterations in methylation, which can cause one or more genes on the single X chromosome in males to be partially silenced or overexpressed, constitute a predisposition to autism spectrum disorders is generally disclosed herein. These alterations provide the rationale and basis for methods to diagnose autism spectrum disorders.

Abstract: The discovery that alterations in methylation, which can cause one or more genes on the single X chromosome in males to be partially silenced or overexpressed, constitute a predisposition to autism spectrum disorders is generally disclosed herein. These alterations provide the rationale and basis for methods to diagnose autism spectrum disorders.

Abstract: The discovery that alterations in methylation, which can cause one or more genes on the single X chromosome in males to be partially silenced or overexpressed, constitute a predisposition to autism spectrum disorders is generally disclosed herein. These alterations provide the rationale and basis for methods to diagnose autism spectrum disorders.

Abstract: The discovery that alterations in methylation, which can cause one or more genes on the single X chromosome in males to be partially silenced or overexpressed, constitute a predisposition to autism spectrum disorders is generally disclosed herein. These alterations provide the rationale and basis for methods to diagnose autism spectrum disorders.