Abstract: The various embodiment methods and systems manage the transportation of high priority medical materials, such as harvested organs from the donor to the recipient, so as to ensure a secure, continuous and monitored transport of such materials. The management systems and methods of the various embodiments provide accountability and ensure the integrity of the organs during transportation by planning, managing and monitoring the organ transportation process. A transport device containing an organ in transit may provide status data to a centralized command center, which may in turn update the planned transplant process as necessary and communicate updates with participants.