Patents Assigned to Gryphon Therapeutics, Inc.
  • Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
    Patent number: 7030217
    Abstract: The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution. Also provided are methods of monitoring solid phase sequential ligation reactions using MALDI or electrospray ionization mass spectrometry of reaction products.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: April 18, 2006
    Assignee: Gryphon Therapeutics, Inc.
    Inventors: Lynne Canne, Stephen B. H. Kent, Reyna Simon
  • N-terminal modifications of RANTES and methods of use
    Patent number: 6942852
    Abstract: N-terminally modified RANTES derivatives are disclosed. The derivatives effectively block the inflammatory effects of RANTES, and are useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, and rheumatoid arthritis. Additionally, the compounds are useful for the treatment of HIV infection.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: September 13, 2005
    Assignee: Gryphon Therapeutics, Inc.
    Inventors: Robin E. Offord, Darren Thompson, Jill Wilken
  • Modular protein libraries and methods of preparation
    Patent number: 6844161
    Abstract: Novel proteins and protein libraries are disclosed. The proteins possess one or more functional protein modules from different parent protein molecules. The proteins and protein libraries are exemplified by the preparation of cross-over chemokines that contain various combinations of peptide segments derived from RANTES, SDS-1 and vMIP-I and to vMIP-II. The proteins and libraries are extremely pure and can be provided in non-limiting high yields suitable for diagnostic and high-throughput screening assays.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: January 18, 2005
    Assignee: Gryphon Therapeutics, Inc.
    Inventors: Michael A. Siani, Jill Wilken, Reyna Simon, Stephen B. H. Kent
  • Polyoxime compounds and their preparation
    Patent number: 6663869
    Abstract: A homogeneous polyoxime composition is provided, in which the polyoxime molecules present comprise a first organic baseplate molecule, which is a polypeptide, wherein the baseplate molecule is linked to at least two second organic molecules, which may be the same or different from one another. In the compositions, the linkages between the baseplate and said organic molecules are oxime linkages formed by reaction of an orthogonal reactive group on each the organic molecules with a complementary orthogonal reactive group on the baseplate.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: December 16, 2003
    Assignee: Gryphon Therapeutics, Inc.
    Inventors: Keith Rose, Robin E. Offord
  • Polyamide chains of precise length
    Patent number: 6552167
    Abstract: Provided are chains of precise length and methods for their preparation. These chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water soluble oligomer, preferably polyethylene glycol. These chains are then used to chemically modify target macromolecules such as biologically important polypeptides.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: April 22, 2003
    Assignee: Gryphon Therapeutics, Inc.
    Inventor: Keith Rose