Abstract: A portable multi-functional endoscopic device and method for use in the examination of tissue within a corporeal orifice to permit diagnostic, therapeutic or anatomical assessment data to be transmitted, recorded, or analyzed. The device includes a base unit sized and configured to be held in a human hand to permit functional and directional control of the device, an interchangeable head assembly sized and configured to be inserted into the orifice being removably connectable to the base unit, and an inflatable tissue stabilizer disposed external to a distal end of the device. In preferred aspects, the endoscopic device has an image sensor, light source, lens, air pump, and working tools.