Abstract: The invention relates to a device suitable for use in the intermittent or even continuous administration of a therapeutic substance such as insulin or morphine.The device comprises a cannula of biocompatible plastics material for indwelling in a patient and defining a through-passsage, together with a hub also defining a through-passage. The respective cannula and hub passages are isolatable from each other by separator means such as a self-sealing diaphragm disposed between them. In the device the arrangement of the respective passages themselves together with said diaphragm or the like is such as to permit a needle to penetrate the hub and cannula through them and, when necessary, to extend beyond the distal end of the cannula. The through-passage of the hub is also constructed and arranged so that it guides an injection needle passed therethrough to pass through the diaphragm at a position where the needle is aligned with the through-passage of the cannula.

Abstract: A catheter with liquid flow control means having a hub portion and a bore therethrough, where the hub portion is resiliently distortable to close the bore by manual pressure prior to connection of the hub portion to other apparatus, but closure of the bore by manual pressure is prevented after the connection has been made.