Abstract: The present invention provides a novel and improved process for the preparation of Tavaborole of Formula (I) and its pharmaceutically acceptable salts. The present invention also provides novel intermediates and process for the preparation of intermediates used in the preparation of Tavaborole. The present invention also provides an improved process for the preparation of Tavaborole and pharmaceutically acceptable salts thereof, that is commercially and industrially scalable.

Abstract: An example system includes a passive dampener device having a chamber to hold a fluid. The passive dampener device is fluidically coupleable to a pump and a microfluidic device. The chamber has an air headspace to dampen pressure waves created by the pump in a sample fluid flow through the microfluidic device.

Abstract: Features for a solar generation system. The system includes a solar generator that may be installed on a shipping container. The solar generator includes one or more deployable rotating solar arrays. The rotating solar arrays may be deployed and stowed using actuators. The rotating solar arrays may be stowed for transport of the system on ships or to remote locations. The solar panels of the array are unexposed when stowed. A base frame with corner castings may attach to standard connections on cargo containers. The solar generators may be stacked on top of each other when stowed for transport. An actuation system may include linear actuators with two arms connecting at a moving pivot point that attach to a base frame and to the panels for deployment. Another actuation system may include end-mounted linear actuation arms with panel backside-mounted deployment arms.

Abstract: A recirculating high pressure lipid extractor includes a kettle with a sealed interior configured for pressurizing and heating a fluid mixture. A flow funnel is positioned in a lower portion. A removable material basket is positioned on top of the flow funnel in an upper section. The removable material basket is configured to hold a material inside the removable material basket. A drain and inlet port is at a bottom of the kettle in communication with the sealed interior of the kettle. A recirculation port is approximate a top of the kettle in communication with the sealed interior of the kettle. Wherein, when the fluid mixture is inserted into the kettle, the recirculating high pressure lipid extractor is configured to pressurize and heat the fluid mixture and recirculate the pressurized and heated fluid mixture from the recirculation port into the drain and inlet port.

Abstract: Disclosed is a mattress control method, comprising the steps of obtaining biometric information of a user, outputting vibration based on a sound source according to a comparison result between the biometric information and a threshold value, and transmitting at least one of the biometric information, the threshold value, and mattress control information to an external controller, wherein the biometric information includes at least immobility state duration information as sub-information, the threshold value includes at least an immobility state duration threshold value, and the vibration is output when the immobility state duration information exceeds the immobility state duration threshold value, and is output based on external control information when the external control information is received from the external controller.

Abstract: The present invention provides a novel and improved process for the preparation of Crisaborole of Formula (I) and its pharmaceutically acceptable salts. The present invention also provides novel intermediates and process for the preparation of intermediates used in the preparation of Crisaborole. The present invention also provides an improved process for the preparation of Crisaborole and pharmaceutically acceptable salts thereof, that is commercially and industrially scalable.

Abstract: A mattress combined with a sound vibration module and air fibers, and an operating method therefor. An air mattress to which air fibers are applied comprises a sound vibration module comprising a speaker, a tactile transducer, a controller, and an amplifier, the sound vibration module being manipulated to generate low-frequency vibration through the conversion of an input sound source into vibration or sound after being amplified, and at the same time emit same as sound. While sound vibration stimuli are applied to the skin through the sound vibration module, contact pressure is distributed on the air mattress to which air fibers are applied, and a static pressure state can be maintained as a fluctuating pressure state. Moreover, the effect of improving muscle strength by healing of muscle cells, blood flow improvement, and low-frequency vibration can be realized through vibration stimulation, to thereby stably prevent the occurrence of bedsore.

Abstract: A recirculating high pressure lipid extractor includes a kettle with a sealed interior configured for pressurizing and heating a fluid mixture. A flow funnel is positioned in a lower portion. A removable material basket is positioned on top of the flow funnel in an upper section. The removable material basket is configured to hold a material inside the removable material basket. A drain and inlet port is at a bottom of the kettle in communication with the sealed interior of the kettle. A recirculation port is approximate a top of the kettle in communication with the sealed interior of the kettle. Wherein, when the fluid mixture is inserted into the kettle, the recirculating high pressure lipid extractor is configured to pressurize and heat the fluid mixture and recirculate the pressurized and heated fluid mixture from the recirculation port into the drain and inlet port.

Abstract: Features for a mobile solar generator. The system includes a deployable solar array using an actuator and torsion springs. The array can be locked into place after deployment. The array stows for transport of the system to remote locations. The solar panels of the array are unexposed when stowed, and secured into place using various locking mechanisms in both the stowed and deployed configurations. Tamper-resistant hardware is included in the solar array to prevent theft and damage.

Abstract: The present invention provides a novel and improved process for the preparation of Crisaborole of Formula (I) and its pharmaceutically acceptable salts. The present invention also provides novel intermediates and process for the preparation of intermediates used in the preparation of Crisaborole. The present invention also provides an improved process for the preparation of Crisaborole and pharmaceutically acceptable salts thereof, that is commercially and industrially scalable.

Abstract: The present invention provides a novel and improved process for the preparation of Crisaborole of Formula (I) and its pharmaceutically acceptable salts. The present invention also provides novel intermediates and process for the preparation of intermediates used in the preparation of Crisaborole. The present invention also provides an improved process for the preparation of Crisaborole and pharmaceutically acceptable salts thereof, that is commercially and industrially scalable.

Abstract: A method for producing a sandwich metal part (1) having a non-developable shape. The part including a metal honeycomb core (2) and two metal skins (4) arranged to either side of the core. The method including: a step of plastically deforming metal sheets (4?) for obtaining the two metal skins (4); then, a step of rigidly connecting the two metal skins (4) to the core (2).

Abstract: The present invention provides a novel and improved process for the preparation of Crisaborole of Formula (I) and its pharmaceutically acceptable salts. The present invention also provides novel intermediates and process for the preparation of intermediates used in the preparation of Crisaborole. The present invention also provides an improved process for the preparation of Crisaborole and pharmaceutically acceptable salts thereof, that is commercially and industrially scalable.

Abstract: The present invention provides a novel and improved process for the preparation of Tavaborole of Formula (I) and its pharmaceutically acceptable salts. The present invention also provides novel intermediates and process for the preparation of intermediates used in the preparation of Tavaborole. The present invention also provides an improved process for the preparation of Tavaborole and pharmaceutically acceptable salts thereof, that is commercially and industrially scalable.

Abstract: A system to permit a diver to quickly adjust a one-piece continuous piece of webbing by simply pushing or pulling the webbing in the desired direction. The system includes accessory plate which is fixed to an existing diving backplate, which allows the webbing to slide on through the attached accessories without affecting the location of the accessories with respect to the diver's body. An improved adjustable crotch strap is also secured to the backplate. An ergonomic backplate frame is also disclosed.

Abstract: An attachment for a harmonica or a pulmonary harmonica may include a resistance band or modified comb which increases respiratory resistance from the typical open holes of harmonicas. The resistance band or modified comb may prevent a broken reed from being inhaled into the mouth.

Abstract: Devices and methods that regulate the innervation of the kidney by detection and modification of the aorticorenal ganglion. Devices for percutaneous detection and treatment of the aorticorenal ganglion via a blood vessel to modify renal sympathetic activity.

Abstract: Described are devices, methods, and kits for controlled incremental filtration (CIF), as well as methods of designing CIF devices. For example, a method for CIF may modulate a concentration of particles of a desired size in a fluid. The fluid including the particles may be flowed along a flow path through a central channel to contact a plurality of gaps that fluidically couple the central channel to at least one adjacent side channel network. Flow resistance may be decreased along at least a portion of the flow path effective to modulate the concentration of particles. The method may include selecting the plurality of gaps to be larger than the particles. The method may include causing a consistent flow fraction fgap in the central channel to traverse each gap in the plurality of gaps and flow through the at least one side channel network along the flow path.

Abstract: Devices and methods that regulate the innervation of the kidney by detection and modification of the aorticorenal ganglion. Devices for percutaneous detection and treatment of the aorticorenal ganglion via a blood vessel to modify renal sympathetic activity.

Abstract: Described are systems, methods, and kits for compression sedimentation and whole blood separation. For example, a compression sedimentation system may include a compression stage configured to accept a flexible reservoir configured to contain a liquid mixture. The compression stage may include a base substrate and a compression substrate configured to apply a force to the flexible reservoir effective to create a pressure in the liquid mixture. An apparatus for whole blood separation may include a sedimentation system that separates whole blood into a supernatant including platelet rich plasma and a subnatant including red blood cells. At least one platelet-concentrating device may be included to receive the supernatant including the PRP and to separate a platelet concentrate and a platelet poor plasma from the supernatant.