Abstract: The present invention relates to the field of medical imaging, and in particular to imaging of disease states associated with the upregulation of the chemokine receptor 5 (CCR5). Imaging agents, precursors and methods are provided which are useful in imaging such disease states.

Abstract: During data acquisition in a tomographic scan of a subject unscattered events and scatter events are collected. The data are corrected for the scatter events and movement of the subject during the scan. A scatter estimate is derived for use in the reconstruction of an image of the subject; a first step in the derivation has a first dependence on the movement of the subject. The image of the subject is derived from the detected events using the scatter estimate; a second step in this derivation has a second dependence on the movement of the subject, the dependence being different from that of the first step.

Abstract: The invention relates to a compound of formula (I) having use for in vivo imaging of the NR2B subtype of the NMDA receptor.

Abstract: A method of conducting motion correction for a tomographic scanner including a detector array for detecting radiation to generate detector data. The method comprises storing detector data collected during a data acquisition period, the detector data being indicative of directions along which radiation is detected and quantities of radiation detected in different of said directions. The method involves storing movement data representing movement of the subject during the data acquisition period and motion correcting the detector data using the movement data and a motion correction algorithm to calculate motion corrected detector data.

Abstract: The method calculates a scatter estimate for annihilation photons in a subject having a distribution of attenuation. The method can be used for scatter correction of detection data from a positron emission tomographic scanner. The method uses the following steps: —select a first scatter point S1 and a second scatter point S2, —determine a first scatter probability for scattering of a photon at scatter point S1 and a second scatter probability for scattering of a photon at scatter point S2, —determine an integral of the attenuation over a line connecting S1 and S2, —multiply the integral and the scatter probabilities and use the product in the calculation of the scatter estimate.

Abstract: Radiolabelled acid chlorides may be synthesised by reacting a radiolabelled carboxylic acid with a solid-phase supported chlorinating agent.

Abstract: Detector efficiency data is generated for a positron emission tomography scanner (2) including a single photon source by conducting a blank scan acquisition procedure using the single photon source. The acquired detection count data is processed using an efficiency estimation algorithm to calculate data efficiencies of individual detectors in the detector array (8). In one embodiment, the detection count data is output as artificial coincidence count data and the efficiency estimation algorithm operates on the artificial coincidence count data. The method can be used in a non-rotating scanner or a rotating scanner.

Abstract: The invention relates to a process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-I+-TRACER (I) Y? wherein the TRACER is of formula (A): or an amine protected derivative thereof, wherein Y? is an anion, preferably trifluoromethylsulphonate (triflate) anion; and R1 is either (i) a group CH—NP1AP2A in which P1A and P2A are each independently hydrogen or a protecting group, or (ii) a carbonyl group; with 18F? to produce the labelled tracer of formula (II) or an amine protected derivative thereof, wherein R1 is as defined for the compound of formula (I).

Abstract: A method of conducting motion correction for a tomographic scanner including a detector array for detecting radiation to generate detector data. The method comprises storing detector data collected during a data acquisition period, the detector data being indicative of directions along which radiation is detected and quantities of radiation detected in different of said directions. The method involves storing movement data representing movement of the subject during the data acquisition period and motion correcting the detector data using the movement data and a motion correction algorithm to calculate motion corrected detector data.