Patents Assigned to Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
  • METHODS FOR TREATING IMMUNOLOGIC DISEASE USING AMINOTHIAZOLE-BASED INHIBITOR OF MYD88
    Publication number: 20140073648
    Abstract: A method of treating an immunologic disease. The method includes administering an aminothiazole-based inhibitor of myeloid differentiation protein 88 (MyD88) to a patient in need thereof. The inhibitor of MyD88 acts as an immunomodulator for treatment of the immunologic disease including but not limited to rejections after organ transplantation, chronic inflammatory diseases, autoimmune diseases, ischemia-reperfusion injuries, and endotoxemia and sepsis.
    Type: Application
    Filed: September 1, 2013
    Publication date: March 13, 2014
    Applicants: Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
    Inventors: Ping ZHOU, Fengchao JIANG
  • 2-AMINOTHIAZOLE DERIVATIVES AND METHODS OF PREPARING AND USING THE SAME
    Publication number: 20140004155
    Abstract: 2-aminothiazole derivatives represented by formula (I), where R1 and R2 represent cycloalkyls, respectively; or R1 represents a substituted aromatic group, and R2 represents H, a C1-C11 alkyl, —CH2Ph (benzyl), or a methyl ether including a C1-C11 alkyl. R3 is a substituent including an amino group. X represents a carbonyl or a methylene and n is an integer from 0 to 5.
    Type: Application
    Filed: September 1, 2013
    Publication date: January 2, 2014
    Applicants: Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., Huazhong University of Science & Technology
    Inventors: Fengchao JIANG, Ping ZHOU, Jianguo CHEN, Yue WANG, Baoshuai CAO, Jia YAN