Abstract: A method of preparing fibrinogen concentrate from blood plasma by cooling said plasma from a temperature above 0.degree. C. to a first temperature between -10.degree. C. and -40.degree. C., thawing the solid material thus obtained to a temperature near the freezing point of water and subsequently physically separating the solid matter and the liquid main fraction of the plasma, viz. water, whereby the thawing is effected in steps from the first temperature to a conditioning temperature between -5.degree. C. and -1.degree. C., after which the size of the solid material is reduced and the reduced material is brought to a temperature at which the main fraction of the plasma, viz. water, becomes liquid and the solubility of fibrinogen in said fluid is as low as possible, after which fluid is separated from the fibrinogen concentrate. The invention also relates to a device for carrying out this method.
Type:
Grant
Filed:
July 17, 1992
Date of Patent:
June 14, 1994
Assignee:
Harimex-Ligos B.V.
Inventors:
Frederik S. van Dommelen, Gerrit Wijngaards
Abstract: A method for purifying blood plasma by treating said blood plasma with powdery or granular active carbon whereby the purification is carried out continuously by leading the blood plasma, having a pH of 2-5, through a column filled with active carbon, whereby the particle size of said active carbon substantially ranges from 50-500 .mu.m.
Type:
Grant
Filed:
May 7, 1991
Date of Patent:
October 12, 1993
Assignee:
Harimex-Ligos B.V.
Inventors:
Frederik S. van Dommelen, Hendrikus B. J. Roodink