Abstract: Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mammal, human, dog, cat, horse). The compounds are useful as modulators of the mu opioid receptor (MOR) through their binding affinity with that receptor.

Abstract: The invention encompasses a novel transcription factor from Candida albicans, TFIIB, a nucleic acid sequence encoding TFIIB, and methods of screening for inhibitors of Candida albicans growth by targeting TFIIB.

Abstract: A process is described for the screening of an agent to determine its effect on the frequency of genome rearrangement in mammals. In particular, mice harboring a p.sup.un mutation are exposed to an agent of interest and the frequency of genome rearrangement relative to that observed in an unexposed mouse is determined. The relative frequency of rearrangement represents a measure of the effect of the agent on the host animal.

Abstract: A muscle fatigue monitor featuring detecting a myoelectric signal and providing a first output signal representative of said myoelectric signal, producing a second output signal corresponding to a portion of said first output signal having components in a selected frequency band, providing a control signal corresponding to the difference in magnitude between said output signals, varying the magnitude of said second signal in accordance with the value of said control signal, and displaying the variation in the frequency spectrum of said myoelectric signal as a function of time.

Abstract: Muscle fatigue monitor featuring, in one aspect, detecting a myoelectric signal and providing an electrical output; providing a first signal corresponding to a portion of said output having frequency components above a first cutoff frequency, and a second signal corresponding to a portion of said output having frequency components below a second cutoff frequency; providing a control signal corresponding to the difference in magnitude between said first and second signals; varying said cutoff frequencies in accordance with the value of said control signal; and displaying the variation of said cutoff frequencies as a function of time.