Patents Assigned to Hauser, Inc.
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Patent number: 10393566Abstract: According to at least one aspect of the present disclosure, a centering device includes a body including a first part and a second part connected by a hinge, the hinge structured to enable the first part and the second part to pivot relatively each other about the hinge to form a center channel extending through the body and defining a center axis. The body further includes a clasp, structured to reversibly hold the first part adjacent the second part in an assembled state, and a plurality of members extending radially from the body where, in the assembled state, the center channel and the clasp structured to reversibly attach to a body passing through the center channel.Type: GrantFiled: July 21, 2017Date of Patent: August 27, 2019Assignee: Endress+Hauser Inc.Inventors: Eugene E. Henry, Trevor Yenna
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Patent number: 7165467Abstract: In order to provide means for allowing a time and cost effective use of measurement instruments (1, 21, 22, 41, 55) in industrial applications where high standard of hygiene need to be fulfilled, a disposable sterilizable liner (15, 27, 28, 51, 67) for a level, pressure or temperature measurement instrument (1, 21, 22, 41, 55) for measuring level, pressure or temperature of a product (9) in a container (3), for use in combination with a disposable container liner (13) covering an interior of the container (3), is described, wherein the measurement instrument (15, 27, 28, 51, 67) comprises: a sensing element (5, 23, 47, 59) for sensing a physical quantity, and a process connector (7, 25, 43, 57) for mounting the sensing element (5, 23, 47, 59) on a counter connector (11, 29, 53) on the container (3), wherein the liner (15, 27, 28, 51, 67) for the measurement instrument (1, 21, 22, 41, 55) is one integral element made out of an elastic material has a shape that exactly follows outer contours of the sensing elemType: GrantFiled: March 14, 2005Date of Patent: January 23, 2007Assignee: Endress + Hauser Inc.Inventors: Daniel T. Klees, Ola J. Wesstrom, Scott A. Richardson
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Patent number: 6780442Abstract: This invention includes both a one-column process and a two-column process for the preparation of compositions enriched for anthocyanins from a crude plant extract. Both processes include a novel column purification step using a brominated polystyrene resin. This invention also includes extracts enriched for anthocyanins.Type: GrantFiled: August 30, 2001Date of Patent: August 24, 2004Assignee: Hauser, Inc.Inventors: David T. Bailey, Delano R. Freeberg, Dennis Gertenbach, Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, F. Joseph Daugherty
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Patent number: 6753345Abstract: An antitumor compound of formula (5): Also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the 2′ and 7 positions of paclitaxel is followed by the hydrolysis of the 2′ hexanoate group resulting in 7-hexanoyltaxol.Type: GrantFiled: July 19, 2002Date of Patent: June 22, 2004Assignee: Hauser, Inc.Inventors: Christopher K. Murray, Qun Y. Zheng, Sagar R. Shakya
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Patent number: 6638555Abstract: A method of preparing storage-stable, citrus-flavored compositions containing comprising citral or a citral derivative as the flavoring agent and a plant extract as the stabilizing agent. The plant extract inhibits the formation of p-methylacetophenone, thereby preventing the development of off-flavors and off odors and increasing the shelf life of the composition.Type: GrantFiled: October 19, 2001Date of Patent: October 28, 2003Assignee: Hauser, Inc.Inventors: Virginia R. Bank, David T. Bailey, Johan T. van Leersum
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Patent number: 6596776Abstract: The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia.Type: GrantFiled: April 25, 2002Date of Patent: July 22, 2003Assignee: Hauser, Inc.Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
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Patent number: 6586464Abstract: Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is I and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.Type: GrantFiled: June 22, 2001Date of Patent: July 1, 2003Assignees: Johns Hopkins University, Hauser, Inc.Inventors: Gary H. Posner, Hardwin O'Dowd, Suji Xie, Theresa A. Shapiro, Christopher Murray
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Publication number: 20030083367Abstract: An antitumor compound of formula (5): 1Type: ApplicationFiled: July 19, 2002Publication date: May 1, 2003Applicant: Hauser, Inc.Inventors: Christopher K. Murray, Qun Y. Zheng, Sagar R. Shakya
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Patent number: 6399579Abstract: Compositions for maintaining normal sexual function and treating sexual dysfunction in males and females comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin, derived from extracts of plants belonging the Epimedium genus, and methods for preparing the same, are provided. The methods comprise subjecting an Epimedium extract to mild acid hydrolysis. Methods for maintaining normal sexual function and treating sexual dysfunction in both males and females are also provided, comprising oral administration of an effective amount of a novel composition of this invention comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin.Type: GrantFiled: August 15, 2000Date of Patent: June 4, 2002Assignee: Hauser, Inc.Inventors: Rod Lenoble, Steven L. Richheimer, David Bailey, Coralee G. Mannila, Rebecca L. Nichols
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Patent number: 6306450Abstract: Storage-stable, citrus-flavored compositions comprising citral or a citral derivative as the flavoring agent and a plant extract as the stabilizing agent. The plant extract inhibits the formation of p-methylacetophenone, thereby preventing the development of off-flavors and off odors, and increasing the shelf life of the composition.Type: GrantFiled: June 23, 1998Date of Patent: October 23, 2001Assignee: Hauser, Inc.Inventors: Virginia R. Bank, David T. Bailey, Johan T. van Leersum
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Patent number: 6297272Abstract: Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is 1 and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.Type: GrantFiled: January 12, 1999Date of Patent: October 2, 2001Assignees: Hauser, Inc., Johns Hopkins UniversityInventors: Gary H. Posner, Hardwin O'Dowd, Suji Xie, Theresa A. Shapiro, Christopher Murray
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Patent number: 6210679Abstract: The process of the present invention relates to the isolation and purification of caffeine-free mixtures catechins from various different biomass sources, preferably from green tea leaves. More particularly, the present invention relates to a four-step process whereby highly pure, caffeine-free EGCG is isolated in high yields. These catechins may be used in pharmaceutical, nutraceutical and cosmetic products.Type: GrantFiled: January 7, 1999Date of Patent: April 3, 2001Assignee: Hauser, Inc.Inventors: David T. Bailey, Ralph L. Yuhasz, BoLin Zheng
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Patent number: 6160004Abstract: The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes; or when n is 3, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.Type: GrantFiled: October 30, 1998Date of Patent: December 12, 2000Assignees: Hauser, Inc., Johns Hopkins UniversityInventors: Gary H. Posner, Soon Hyung Woo, Poonsakdi Ploypradith, Michael H. Parker, Theresa A. Shapiro, Jeffrey S. Elias, John Northrop, Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh
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Patent number: 6156790Abstract: The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.Type: GrantFiled: December 30, 1997Date of Patent: December 5, 2000Assignees: Hauser, Inc., Johns Hopkins UniversityInventors: Gary H. Posner, Soon Hyung Woo, Poonsakdi Ploypradith, Michael H. Parker, Theresa A. Shapiro, Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh
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Patent number: 6136988Abstract: An antitumor compound of formula (5) ##STR1## and also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the 2' and 7 positions of paclitaxel is followed by the hydrolysis of the 2' hexanoate group resulting in 7-hexanoyltaxol.Type: GrantFiled: April 10, 1998Date of Patent: October 24, 2000Assignee: Hauser, Inc.Inventors: Christopher K. Murray, Qun Y. Zheng, Sagar R. Shakya
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Patent number: 6132726Abstract: In general the present invention relates to a process for the removal of undesireable compounds or residues from an extract which are more polar or less polar than the desired target compound. The preferred embodiment of the present invention is a three step process and is described in detail below. The first step includes contacting a plant material that contains the desired target compound(s) with a solvent, thus producing a crude extract containing a mixture of compounds that includes, in addition to the undesireable residues, the desired target compound(s). The second step involves passing the crude extract through a series of columns containing an absorbent that retards the movement of the undesireable compounds, while allowing the desired compounds to pass. The third and final step involves drying the eluant product to achieve a final product.Type: GrantFiled: October 21, 1998Date of Patent: October 17, 2000Assignee: Hauser, Inc.Inventors: Randall J. Daughenbaugh, David T. Bailey, William R. Gamble, Dennis D. Gertenbach
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Patent number: 6004997Abstract: Novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.Type: GrantFiled: November 23, 1998Date of Patent: December 21, 1999Assignees: Hauser, Inc., Johns Hopkins UniversityInventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner
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Patent number: 5908650Abstract: An improved pigment composition containing an anthocyanin pigment and a pigment-improving agent selected from the group consisting of flavonoid glycuronides, flavonoid glucuronides, and caffeic acid derivatives. The pigment-improving agents deepen and improve the intensity of the anthocyanin pigment and increase its stability in the presence of light, heat and/or pH.Type: GrantFiled: October 20, 1995Date of Patent: June 1, 1999Assignee: Hauser, Inc.Inventors: Rod Lenoble, Steven L. Richheimer, Virginia R. Bank, David T. Bailey
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Patent number: 5892063Abstract: An antitumor compound of formula (5) ##STR1## in which R is Ac or H, and R.sub.1, R.sub.2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R.sub.3 is H; R.sub.1 and R.sub.2 and R.sub.3 are H; R.sub.1 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R.sub.2, R.sub.3 is H; R.sub.1 and R.sub.3 are H, R.sub.2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R.sub.1 is H, R.sub.2 and R.sub.3 are an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R.sub.1 and R.sub.2 and R.sub.3 are an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and t-Bu is tert-butyl. Also provided by the invention is a one step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.Type: GrantFiled: May 21, 1997Date of Patent: April 6, 1999Assignee: Hauser, Inc.Inventors: Qun Y. Zheng, Christopher K. Murray, Randall J. Daughenbaugh
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Patent number: RE38117Abstract: Described herein are novel trioxane dimers of structure which possess antiproliferative and antitumor activities.Type: GrantFiled: November 21, 2000Date of Patent: May 6, 2003Assignees: Hauser, Inc., Johns HopkinsInventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner