Patents Assigned to Heartlab, Inc.
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Patent number: 11940452Abstract: Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.Type: GrantFiled: October 29, 2019Date of Patent: March 26, 2024Assignee: Cleveland Heartlab, Inc.Inventors: Cory Bystrom, Timothy Collier
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Patent number: 11571533Abstract: Provided is a configuration capable of executing a detection test for a comfort level including the quality of sleep, which is measurable at home without requiring the measurement of brain waves or electrocardiogram. The respiratory waveform of a subject during sleep is continuously measured and recorded from the respiratory gas flow, etc., and is window-Fourier transformed at each measurement time to generate a frequency spectrum, and a bandwidth including a respiratory frequency is extracted. The index indicating the regularity of the respiratory period of the subject is also calculated at each time point during the sleep, and the time-dependency of this index during the sleep is represented as a graph. A medical device includes a sleep evaluation system equipped with a control means for performing control so that a sleep cycle repeated at a cycle of about 90 minutes is clearly observed if the comfort level including the quality of sleep of the subject is favorable.Type: GrantFiled: September 18, 2018Date of Patent: February 7, 2023Assignees: HEARTLAB INC.Inventor: Hidetsugu Asanoi
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Publication number: 20220155302Abstract: Provided herein are methods, systems, and compositions for Lp-PLA2 detection assays that employ amounts of detergent to liberate all or nearly all of the Lp-PLA2 molecules from associated lipoprotein particles. In this regard, the true Lp-PLA2 concentration can be detected in a sample, which correlates better with known Lp-PLA2 activity assays.Type: ApplicationFiled: January 31, 2022Publication date: May 19, 2022Applicant: CLEVELAND HEARTLAB, INC.Inventors: Celalettin Topbas, Cory Bystrom
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Patent number: 11237167Abstract: Provided herein are methods, systems, and compositions for Lp-PLA2 detection assays that employ amounts of detergent to liberate all or nearly all of the Lp-PLA2 molecules from associated lipoprotein particles. In this regard, the true Lp-PLA2 concentration can be detected in a sample, which correlates better with known Lp-PLA2 activity assays.Type: GrantFiled: January 18, 2018Date of Patent: February 1, 2022Assignee: Cleveland Heartlab, Inc.Inventors: Celalettin Topbas, Cory Bystrom
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Publication number: 20210373038Abstract: The present invention provides methods, kits, and compositions for purifying HDL molecules from a sample (e.g., blood sample) using HDL tagging molecules comprising an HDL lipophilic core binding peptide (e.g., portion of ApoA1) and an affinity tag. The present invention also provides methods, kits, and compositions for detecting non-fragmented ApoA1 with mass spectrometry. The present invention further provides methods, kits, and compositions for tagging HDL molecules in a sample with detectably labeled ApoA1 molecules such that the ratio of detectably labeled ApoA1 molecules to native ApoA1 proteins may be determined.Type: ApplicationFiled: July 2, 2021Publication date: December 2, 2021Applicant: CLEVELAND HEARTLAB, INC.Inventors: Timothy Collier, Cory Bystrom, Angela Higgins
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Patent number: 11061039Abstract: The present invention provides methods, kits, and compositions for purifying HDL molecules from a sample (e.g., blood sample) using HDL tagging molecules comprising an HDL lipophilic core binding peptide (e.g., portion of ApoA1) and an affinity tag. The present invention also provides methods, kits, and compositions for detecting non-fragmented ApoA1 with mass spectrometry. The present invention further provides methods, kits, and compositions for tagging HDL molecules in a sample with detectably labeled ApoA1 molecules such that the ratio of detectably labeled ApoA1 molecules to native ApoA1 proteins may be determined.Type: GrantFiled: December 4, 2018Date of Patent: July 13, 2021Assignee: Cleveland Heartlab, Inc.Inventors: Timothy Collier, Cory Bystrom, Angela Higgins
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Publication number: 20210132090Abstract: Provided herein are methods, systems, and compositions for detecting one or more HDL-associated proteins (e.g., ApoC3; ApoC3 and ApoA1; ApoC3 and SAA1/2; or proteins in Biomarker Panels 1-30) in a sample from a subject with, or suspected of having, cardiovascular disease (CVD) or other HDL related disease. In certain embodiments, such methods, systems, and compositions are used to determine the approximate risk of CVD (or other disease) for a subject, and/or the approximate cholesterol efflux capacity (CEC) of a sample.Type: ApplicationFiled: January 7, 2021Publication date: May 6, 2021Applicant: Cleveland Heartlab, Inc.Inventors: Cory Bystrom, Timothy Collier
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Patent number: 10921331Abstract: Provided herein are methods, systems, and compositions for detecting one or more HDL-associated proteins (e.g., ApoC3; ApoC3 and ApoA1; ApoC3 and SAA1/2; or proteins in Biomarker Panels 1-30) in a sample from a subject with, or suspected of having, cardiovascular disease (CVD) or other HDL related disease. In certain embodiments, such methods, systems, and compositions are used to determine the approximate risk of CVD (or other disease) for a subject, and/or the approximate cholesterol efflux capacity (CEC) of a sample.Type: GrantFiled: July 21, 2017Date of Patent: February 16, 2021Assignee: Cleveland Heartlab, Inc.Inventors: Cory Bystrom, Timothy Collier
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Publication number: 20200116744Abstract: Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.Type: ApplicationFiled: October 29, 2019Publication date: April 16, 2020Applicant: CLEVELAND HEARTLAB, INC.Inventors: Cory Bystrom, Timothy Collier
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Patent number: 10466260Abstract: Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.Type: GrantFiled: October 20, 2017Date of Patent: November 5, 2019Assignee: Cleveland Heartlab, Inc.Inventors: Cory Bystrom, Timothy Collier
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Patent number: 9810702Abstract: Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.Type: GrantFiled: September 18, 2015Date of Patent: November 7, 2017Assignee: THE CLEVELAND HEARTLAB, INC.Inventors: Cory Bystrom, Timothy Collier
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Publication number: 20150376704Abstract: The disclosed methods, assays and kits identify biomarkers, particularly miRNA and/or protein biomarkers, for assessing the cardiovascular health of a human. In certain embodiments, methods, assays and kits, circulating miRNA and/or protein biomarkers are identified for assessing the cardiovascular health of a human.Type: ApplicationFiled: July 1, 2015Publication date: December 31, 2015Applicant: CLEVELAND HEARTLAB, INC.Inventors: Doug Harrington, Evangelos Hytopoulos, Bruce Phelps
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Patent number: 7842506Abstract: The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient's Apo E information; and 3) an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a diet and treatment plan for the patient.Type: GrantFiled: February 6, 2007Date of Patent: November 30, 2010Assignee: Berkeley Heartlab, Inc.Inventors: Christopher Hall, Vance Lanier, Jr., David T. Shewmake
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Patent number: 7647234Abstract: The disclosure relates to an interactive, web based cardiovascular healthcare management system which has an infomediary site with databases having information relating to cardiovascular disease risk factors such as age, blood pressure, LDL, HDL and subfractions thereof and cardiovascular disease management such as diet, exercise, drugs and cardiovascular education materials. The physician can communicate electronically with the infomediary site to obtain patient test results and formulate a patient treatment plan from the diet, exercise and drug data. The physician can electronically communicate treatment plans to the patient through a record in the infomediary site. The patient can electronically communicate compliance information to the physician through the patient record. The infomediary site may also provide a case manager to provide initial draft treatment plans to the physician, gather patient history data and/or patient treatment plan compliance data.Type: GrantFiled: March 24, 2000Date of Patent: January 12, 2010Assignee: Berkeley Heartlab, Inc.Inventors: Frank R. Ruderman, David T. Shewmake
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Publication number: 20090188796Abstract: The invention provides a data base of LDL, I, IIa, IIb, IIIa, IIb, IVa, IVb and HDL2a, HDL2b, HDL 3a, HDL 3b and HDL 3c together with patient data such as HDL-C, LDL-C, Apo A, ApoB, Lp(a) and patient personal data useful for treatment, diagnosing, and monitoring cardiovascular disease. The data base contains the LDL and HDL subfraction data in quantitative mg/dl values and permits deriving relationship amongst the LDL and HDL values and cardiovascular disease. Quantitative data permits more effective treatment and monitoring of cardiovascular disease. For example, quantitative differences in LDL and HDL subclass levels can determine the need for more or less aggressive treatment. The data base which includes patient events, procedures, interventions which is correlated to LDL and HDl quantitative subclass data permits development of personalized patient treatment plans and monitoring the effectiveness of such treatment.Type: ApplicationFiled: August 25, 2008Publication date: July 30, 2009Applicant: Berkeley HeartLab, Inc.Inventors: David Shewmake, Frank Ruderman, Christopher Boggess, Faith Clendenen
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Publication number: 20090118381Abstract: Described are polymer monolith compositions for separating high density lipoprotein, as well as related methods of use.Type: ApplicationFiled: December 4, 2007Publication date: May 7, 2009Applicant: Berkeley HeartLab, Inc.Inventors: George Russell Warnick, Gary Hewett
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Patent number: 7416895Abstract: This invention is directed to a data base which contains data for HDL2b, LDL IIIa & LDL IIIb and LDL IVb subclasses all in mg/Dl and which is correlated to cardiovascular disease.Type: GrantFiled: April 12, 2003Date of Patent: August 26, 2008Assignee: Berkeley Heartlab, Inc.Inventors: David Shewmake, Frank Ruderman, Christopher Boggess, Faith Clendenen
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Publication number: 20080021740Abstract: As patient video images are captured in a lab, they are converted into an uncompressed data set and stored locally on a hospital site server, where they are immediately viewable by diagnosticians in the hospital. The hospital site server generates a plurality of compressed data sets for use by the Internet Data Center. Additionally, the uncompressed data set and a plurality of compressed data sets are stored permanently on a centralized Internet Data Center, from which they can be searched out and displayed by any client device running web-browser software. A client is provided with immediate access to the uncompressed images when pausing and requesting the images of interest from the server. The patient video images are automatically delivered to any authorized Clinical Research Organizations, they are delivered back to the treating hospital when the patient returns for subsequent visits, and are viewable through in-hospital viewing stations over a private high-speed network.Type: ApplicationFiled: July 6, 2007Publication date: January 24, 2008Applicant: HEARTLAB, INC.Inventors: John Beane, Larry Heminger, Robert Stone
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Patent number: 7277903Abstract: An archive system is provided for long term storage of large amounts of data that is particularly suited for multi-year storage of medical data such as cardiac images, patient demographics and reports. One or more digital versatile disks (DVDs) may be employed as the storage media. In the archival process, all of the data for a particular patient, procedure or study is stored and uniquely identified within one DVD. Each DVD may have an executable program stored thereon for independently accessing the archived data from the selected DVD. Before the DVD is recorded, the data to be archived is segmented into a plurality of information groups where each group is based on data for the particular patient, procedure or study. Then, the DVD is reviewed to determine whether a sufficient amount of storage space is present to ensure that the information group will be entirely stored within one DVD.Type: GrantFiled: August 2, 2001Date of Patent: October 2, 2007Assignee: Heartlab, Inc.Inventor: Robert R. Petrocelli
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Publication number: 20070224619Abstract: The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient's Apo E information; and 3) an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a diet and treatment plan for the patient.Type: ApplicationFiled: February 6, 2007Publication date: September 27, 2007Applicant: Berkeley HeartLab, Inc.Inventors: Matthew Banet, Randon Schultz, Marshal Dhillon, Adam Fleming, Henk Visser, Christopher Hall, Vance Lanier