Patents Assigned to Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fur Gesundheit und Umwelt GmbH
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Patent number: 8573073Abstract: A method and a device for transferring a microscopic, isolated sample, particularly a membrane-supported micro-dissected specimen, from an object table to an analysis arrangement, with a suction apparatus comprising a nano-suction means with a suction tube and a terminal membrane and a vacuum/overpressure unit which can be coupled to the nano-suction means for sucking or blowing the sample onto or from the terminal membrane; and a carrier apparatus for carrying the nano-suction means, which can be moved by means of an associated positioning unit for positioning the nano-suction means exactly in a sample removal position for sucking the sample onto the terminal membrane and in a sample release position for blowing the sample from the terminal membrane. A micro-dissection system, comprising such a device and a method for the production of a nano-suction means that is used in such a device.Type: GrantFiled: July 23, 2010Date of Patent: November 5, 2013Assignee: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fur Gesundheit und Umwelt GmbHInventors: Stefan Thalhammer, Norbert Hohn, Albert Zink, Wolfgang Heckl
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Publication number: 20130089569Abstract: The invention relates to recombinant MVA which is capable of expressing structural HCV antigens, functional parts of said structural antigens or epitopes of said structural antigens. The invention further relates to a pharmaceutical composition, especially in the form of a vaccine and containing the recombinant MVA according to the invention, to eukaryotic cells that contain the inventive recombinant MVA and to various uses of the recombinant MVA, for example for producing recombinant structural proteins, for producing a pharmaceutical preparation that is suitable for the therapy and prophylaxis of HCV infections and diseases thereby caused. The invention further relates to methods for producing recombinant MVA and recombinant structural HCV polypeptides encoded by said recombinant MVA, and to DNA or RNA of said recombinant MVA.Type: ApplicationFiled: September 21, 2012Publication date: April 11, 2013Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventor: Helmholtz Zentrum München Deutsches
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Patent number: 8409809Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: GrantFiled: August 26, 2011Date of Patent: April 2, 2013Assignees: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Eberhard-Karls-Universitaet Tuebingen, Mayo Foundation For Medical Education and ResearchInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Publication number: 20130041267Abstract: An imaging device for medical imaging includes a light source device arranged to illuminate a sample under investigation with illumination light, a detector device arranged to collect a plurality of images including at least two sample light images backscattered by the sample in different spectral ranges, and at least one marker light image originating from at least one marker substance in the sample, and a processor device adapted to process the at least two sample light images and create at least one correction component, the processor device further adapted to correct the marker light image using the at least one correction component.Type: ApplicationFiled: November 15, 2010Publication date: February 14, 2013Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Vasilis Ntziachristos, George Themelis
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Publication number: 20130024959Abstract: The present invention relates to a method of producing a cell comprising a conditionally active transgene in its genome, the method comprising (a) introducing into the cell a targeting vector, wherein the targeting vector comprises (i) a 5? recombinase recognition site specifically recognised by a first recombinase, wherein the first recombinase is endogenously present in the cell or wherein the first recombinase or a nucleic acid molecule encoding said first recombinase in expressible form is introduced into the cell; followed by (ii) a 5? recombinase recognition site specifically recognised by a second recombinase, wherein the second recombinase is not endogenously present or is not active in the cell; followed by (iii) a selection cassette comprising a positively selectable marker gene; followed by (iv) a 3? recombinase recognition site specifically recognised by a third recombinase, wherein the third recombinase is not endogenously present or is not active in the cell; followed by (v) the transgene; folloType: ApplicationFiled: November 24, 2010Publication date: January 24, 2013Applicants: UNIVERSITY OF FRANKFURT-MEDICAL SCHOOL, HELMHOLTZ ZENTRUM MÜNCHEN-DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)Inventors: Laura Schebelle, Frank Schnütgen, Thomas Floss
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Publication number: 20120220851Abstract: An imaging device configured for optoacoustic imaging of an object, including an illumination device including optical components arranged to illuminate the object, a detector device comprising an array of detector elements arranged in a tank and arranged to detect acoustic signals created in the object, and a container device including a tank arranged to accommodate the detector device, the object and a matching transmission medium, a holding device adapted to position and move the object relative to the illumination device and the detector device, wherein the optical components are arranged in the tank to illuminate the object from different directions.Type: ApplicationFiled: July 23, 2010Publication date: August 30, 2012Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Daniel Razansky, Vasilis Ntziachristos
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Patent number: 8206701Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.Type: GrantFiled: September 16, 2003Date of Patent: June 26, 2012Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Dolores Schendel, Rudolf Wank
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Publication number: 20120123256Abstract: A method of thermoacoustic imaging of an object includes providing thermoacoustic signals representing a mechanical wave response to a delivery of electromagnetic energy into the imaged object, reconstructing an energy deposition image representing a local energy absorption within the object based on the thermoacoustic signals, and decomposing the energy deposition image into a quantitative absorption image representing a distribution of a local absorption coefficient in the object and at least one further image component.Type: ApplicationFiled: June 29, 2009Publication date: May 17, 2012Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Daniel Razansky, Vasilis Ntziachristos, Amir Rosenthal
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Publication number: 20120020940Abstract: The present invention relates to a peptide comprising or consisting of the following amino acid sequence: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12 (formula II), wherein A0 is a hydrophobic amino acid residue or is absent; A1, A4, A7, A8, A12 each are a hydrophobic amino acid residue; and A2, A6, A9, A10 each are a basic amino acid residue; A5 is an alanine or a basic amino acid residue; A3, A11 each are a basic amino acid residue, or a hydrophobic amino acid residue; or a peptidomimetic thereof; wherein the basic amino acid residues are selected from the group consisting of arginine, lysine and histidine; wherein the hydrophobic amino acid residues are selected from the group consisting of leucine, alanine, isoleucine, valine, methionine and phenylalanine; and wherein said peptide or peptidomimetic has antimicrobial and/or antiviral activity.Type: ApplicationFiled: September 24, 2009Publication date: January 26, 2012Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GmbH)Inventors: Jörg Durner, Christian Lindermayr, Ruth Brack-Werner
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Patent number: 8094910Abstract: A method of reconstructing an image function on the basis of a plurality of projection profiles corresponding to a plurality of projection directions through a region of investigation, each projection profile including a series of value positions, wherein measured projection values corresponding to projection lines parallel to the respective projection direction are assigned to respective value positions and a plurality of remaining value positions are empty, comprises the steps of (a) assigning first interpolation values to the empty value positions for constructing a plurality of interpolation profiles on the basis of the projection profiles, wherein the first interpolation values are obtained from a first interpolation within a group of measured projection values having the same value position in different projection profiles, and (b) determining the image function by applying a predetermined reconstruction algorithm on the interpolation profiles.Type: GrantFiled: March 14, 2007Date of Patent: January 10, 2012Assignees: State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Yuan Xu, Oleg Tischenko, Christoph Hoeschen
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Patent number: 8090089Abstract: An imaging method for imaging a region of investigation of an object comprises the steps of generating an energy input beam with an energy beam source, irradiating the region of investigation with energy input beam components of the energy input beam along a plurality of projection directions, the energy input beam components being formed with a frame mask being arranged between the energy input beam and the object and including frame mask windows, measuring first integrated attenuation values of the energy input beam components with an outer detector device arranged outside the frame mask, measuring second integrated attenuation values of the energy input beam components with a frame mask detector device being arranged on an inner surface of the frame mask, and reconstructing an image of the region of investigation based on the first and second integrated attenuation values. Furthermore, an imaging device for imaging a region of investigation of an object is described.Type: GrantFiled: October 25, 2006Date of Patent: January 3, 2012Assignees: State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Oleg Tischenko, Christoph Hoeschen, Yuan Xu
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Patent number: 8081807Abstract: A method of reconstructing an (n+1)-dimensional image function ƒ representing a region of investigation comprises determining the image function ƒ from n-dimensional or less dimensional Radon data comprising a plurality of projection functions p?(t) measured corresponding to a plurality of predetermined projection directions (?), wherein the image function ƒ is determined as a sum of polynomials multiplied with values of the projection functions p?(t). Imaging methods, imaging devices, and computer tomography devices using this reconstruction method are described.Type: GrantFiled: December 21, 2005Date of Patent: December 20, 2011Assignees: State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Yuan Xu, Oleg Tischenko, Christoph Hoeschen
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Publication number: 20110306857Abstract: A method of multi-spectral opto-acoustic tomography (MSOT) imaging of a target tissue including a target tissue biomarker includes illuminating the target tissue with an illumination device emitting at least one pulsed illumination pattern at several illumination wavelengths, detecting pressure signals from the target tissue biomarker with a detector device, wherein the pressure signals being produced in the target tissue are in response to the illumination, and reconstructing a quantitative tomographic image of a distribution of the target tissue biomarker in the target tissue, wherein the pressure signals are analyzed using a photon propagation model which depends on an illuminating light fluence in the target tissue and on the illumination wavelengths, at least one spectral processing scheme, and an inversion scheme providing the tomographic image.Type: ApplicationFiled: July 25, 2008Publication date: December 15, 2011Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Daniel Razansky, Vasilis Ntziachristos
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Publication number: 20110294721Abstract: The present invention relates to a peptide comprising or consisting of a sequence of formula I A-B-C-D-E-F-G-H-I (formula I), wherein A is a peptide consisting of three or four basic amino acid residues; B is a peptide consisting of two to four hydrophobic amino acid residues; C is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; D is a peptide consisting of two hydrophobic amino acid residues; E is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; F is a peptide consisting of three amino acid residues selected from the group consisting of glycine and hydrophobic amino acid residues; G is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; H is a peptide consisting of two or three amino acid residues selected from the group consisting of serine and hydrophobic amino acid residues; I is a peptide consisting of two to four basic amino acid residues; or a pType: ApplicationFiled: September 24, 2009Publication date: December 1, 2011Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GmbH)Inventors: Jörg Durner, Christian Lindermayr, Ruth Brack-Werner
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Publication number: 20110236409Abstract: The present invention relates to set overlapping immunogenic peptides of a variable antigen, and uses thereof, in particular for diagnostic and therapeutic purposes. The present invention relates also to a sub-population of CD8 T cells associated with the non-progressive status in HIV-infected subjects.Type: ApplicationFiled: March 30, 2009Publication date: September 29, 2011Applicant: Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Mauro Severo Malnati, Paolo Lusso, Guido Poli, Antonio Cosma, Volker Erfle
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Publication number: 20110224477Abstract: The disclosure relates to a therapeutic device for treatment of a patient, particularly for cancer treatment, which includes a radiation therapy apparatus for applying an ionizing radiation to the patient, and an integrated thermotherapeutic heating device for inducing a regional hyperthermia in the patient.Type: ApplicationFiled: October 8, 2008Publication date: September 15, 2011Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventor: Rolf Issels
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Publication number: 20110222648Abstract: A scanner device for computed tomography imaging of an object, includes a measurement device including a source device arranged for irradiating the object with at least one beam and a detector device arranged for detecting radiation transmitted through the object, wherein the source device has a fixed position relative the detector device, and a carrier device accommodating the object in a position between the source device and the detector device, wherein the measurement device and the carrier device are capable of a scanning movement relative to each other, and the measurement device and the carrier device have a fixed spatial orientation during the scanning movement. Furthermore, a scanning method for computed tomography imaging of an object is described.Type: ApplicationFiled: June 5, 2009Publication date: September 15, 2011Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH)Inventors: Oleg Tischenko, Matthias Klaften, Christoph Hoeschen, Martin Hrabe de Angelis
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Publication number: 20110059443Abstract: The present invention relates to a nucleic acid molecule encoding a polypeptide having a fluorescence emission activity with a maximum emission at 505 to 515 nm, wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule encoding a polypeptide having the amino acid sequence of SEQ ID NO: 2; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO: 1; (c) a nucleic acid molecule hybridizing under stringent conditions to the complementary strand of (i.Type: ApplicationFiled: August 1, 2008Publication date: March 10, 2011Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Jean-Marie Buerstedde, Hiroshi Arakawa
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Publication number: 20100284976Abstract: The invention relates to a method for in vitro maturation of at least one immature dendritic cell, comprising stimulating said immature dendritic cell with TNF?, IL-1?, IFN?, a TLR7/8 agonist and prostaglandin E2 (PG). Furthermore, the invention relates to a composition comprising said factors as well as to mature dendritic cells produced by the method of the invention.Type: ApplicationFiled: March 28, 2007Publication date: November 11, 2010Applicant: HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)Inventors: Dolores J. Schendel, Anke Zobywalski, Iris Bigalke