Abstract: The present invention relates to stabilized medicaments containing thyroid hormone the stabilizing component of which is sodium thiosulfate in a mass ratio of thyroid hormone to sodium thiosulfate of 1:0.1 to 1:50 and processes for preparing such medicaments.

Abstract: Treatment of hyperuricaemia and gout is possible by agents, among usual carriers and adjuvants containing pharmakologically active doses of oxypurinol alkali and/or alkaline earth salts in amorphous or crystalline form.

Abstract: Chronic inflammatory intestinal diseases may be treated enterally pharmacologically active doses of said oxypurinol and or its alkali, alkaline earth, or ammonium salts.

Abstract: Treatment of hyperuricaemia and gout is possible by agents, among usual carriers and adjuvants containing pharmakologically active doses of oxypurinol alkali and/or alkaline earth salts in amorphous or crystalline form.

Abstract: Described are dry pharmaceutical preparations or clysters designed for rectal administration, which contain an active ingredient or mixture of active ingredients plus additives, and which are only reconstituted immediately before use by the addition of water, the volume of which can be selected to suit the particular patient. Such preparations are preferably marketed in graduated clyster flasks allowing the contents to be diluted with an amount of water appropriate to a particular patient.

Abstract: Formulations of oxypurinol and/or its alkali or alkaline earth salts in non-crystalline form, containing the active substance in the form of a solids dispersion with pharmacologically harmless adjuvants. They have more rapid and higher solubility than oxypurinol and/or its alkali or alkaline earth salts. They can be used for the preparation of drugs having high bioavailability of the active substance oxypurinol.

Abstract: The agent for TSH suppression and for treatment of struma contains a therapeutically effective dose of 3,5-diiodo-L-thyronine and conventional galenic auxiliary materials.

Abstract: A method is known for the determination of osteocalcin in human serum or plasma, in which a sample of the biological fluid containing the osteocalcin to be determined is incubated, together with a defined amount of an oligopeptide tracer, with a suitable anitbody which binds both the osteocalcin and the tracer. This method has proved to be susceptible to error in that the incubation conditions affected the measured levels, and the osteocalcin levels obtained were often too high. The recognition that the observed errors are attributable to a proteolytic breakdown of the oligopeptide tracer by constituents of the serum or plasma resulted in the technical teaching of the addition of one or more proteolysis inhibitors to the sample of human serum or plasma before or together with the addition of the oligopeptide tracer, specifically either a mixture of an endopeptidase inhibitor with an aminopeptidase inhibitor or, when an N-terminally protected oligopeptide tracer is used, only an endopeptidase inhibitor.

Abstract: An apparatus for dispensing a controlled dose of a liquid fluid such as a liquid medication includes a dispenser head which is snugly fitted over the needle-shaped end of a syringe filled with the liquid pharmaceutical and including a piston in fully retracted or drawn position. The syringe with its fully drawn piston is completely encased and protected by a tube which is connected to the dispenser head.

Abstract: Luminescence immuno-test kits consist of an antigen or antibody capable of showing luminescence and labelled with phthalic hydrazides, an antibody or antigen preferably bound to a carrier and an oxidizing reagent inducing the luminescence to occur and are characterized in that the oxidizing reagent is a pre-fabricated solution of catalase, optionally stabilized by a bacteriostat, and the initiator is a pre-fabricated peroxide solution which is at least 20 minutes old. These luminescence immuno-tests are particularly stable and may be subjected to a quality control in a simple and inexpensive way.

Abstract: 5-Aminosalicylic acid O-sulfates of physiologically acceptable bases are new substances which are preparable by esterification of 5-nitrosalicylic acid alkyl esters with carbodiimide and sulfuric acid, alkaline saponification of the alkyl ester group and reduction of the thus obtained 5-nitrosalicylic acid O-sulfates. Said substances are useful as drugs, more specifically for the treatment of colitis ulcerosa, enteritis regionalis Crohn (morbus Crohn), chronic nonspecific colitis and diverticulitis.

Abstract: The compound I ##STR1## prepared by reacting m-nitrobenzaldehyde, ethyl .beta.-aminocrotonate and 2-piperidinoethanol acetoacetate, is endowed with valuable pharmacological properties namely calcium antagonistic activity in vitro and in vivo.

Abstract: Plastics surfaces are preactivated for immobilizing organo-chemical and biologic materials by coating the surfaces with a polypeptide which consists of a defined composition of hydrophobic amino acids and amino acids having side chains capable of activation and coupling. After activation of the plastics surfaces having been coated in this manner with various coupling reagents, it is possible to firmly fix organo-chemical and biologic materials. The materials having been immobilized in this manner are extremely stable to various reaction conditions.

Abstract: Luminescence immunoassays for haptens can be improved and made more sensitive by using a luminescence labelled hapten conjugate which contains as the linkage group a chain-like polymer having repeating functional groups having bound thereto per mole both a plurality of moles of groups capable of luminescence and a plurality of moles of hapten. The antibody used is preferably one which is prepared by the use of another chain-like polymer having bound thereto the hapten by a different chemical reaction.

Abstract: Salicylazobenzoic acid is more useful than salazosulfapyridine for the treatment of colitis ulcerosa, enteritis regionalis (Morbus Crohn), chronic nonspecific colitis and diverticulitis. Salicylazobenzoic acid is used in the form of tablets and dragees or enemae in which it may be used in the form of free acid, compatible salts or mixtures thereof.

Abstract: 1. Immunological method for the determination of free substances having hapten properties.2.1. Immunological methods for the determination of free substances having hapten properties, especially of free thyroid hormones, are based on various determination principles, all of which either have disadvantages from the practical viewpoint or, by reason of the basic principle of the method, provide limited information in marginal cases. The new method is intended to simplify and improve the routine clinical determination of free substances, because of the avoidance of sources of error associated with known methods, while having a procedure which is straightforward for practical use.2.2.