Abstract: A novel carboxypeptidase R (CPR) inhibiting peptide is prepared using rational structure-based strategies, incorporating two principle facts: (a) CPR has a strong affinity for basic amino acids and; and (b) the two lysines and arginine residues of PCI are orientated in the same direction and held in close spatial proximity by three disulfide bonds.
Type:
Grant
Filed:
September 25, 2002
Date of Patent:
December 5, 2006
Assignee:
Hidechika Okada
Inventors:
Hidechika Okada, Eliada Lazoura, William Campbell, Noriko Okada
Abstract: The present invention provides a glycoprotein derived from human cell membrane, which has a molecular weight of 20 to 25 Kd as estimated by SDS polyacrylamide gel electrophoresis, and contains N-glycoside type carbohydrate chain and phosphatidylinositol, and possesses an inhibitory activity to complement-mediated cell membrane damage. The present invention further provides a gene coding for the glycoprotein, and a method for the production of the glycoprotein and the gene therefor.
Abstract: The present invention provides a glycoprotein derived from human cell membrane, which has a molecular weight of 20 to 25 Kd as estimated by SDS polyacrylamide gel electrophoresis, and contains N-glycoside type carbohydrate chain and phosphatidylinositol, and possesses an inhibitory activity to complement-mediated cell membrane damage. The present invention further provides a gene coding for the glycoprotein, and a method for the production of the glycoprotein and the gene therefor.