Patents Assigned to HIL Applied Medical Ltd.
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Publication number: 20230126790Abstract: Particle therapy systems and methods for treating patients are provided. In one implementation, a particle therapy system may include an interaction chamber for containing a target and an electromagnetic radiation source configured to generate a pulsed electromagnetic radiation beam of at least about 100 terawatts and at a repetition rate of at least about 20 Hz. The particle therapy system may further include optics configured to direct the pulsed electromagnetic radiation beam along a path towards a target in the interaction chamber. The particle therapy system may further include an actuator configured to cause relative movement between the target and the electromagnetic radiation beam at a speed associated with the repetition rate of the electromagnetic radiation source, to thereby vary a location of interaction of the pulsed electromagnetic radiation beam on a surface of the target and thereby cause a resultant emission from the target of at least about 3×106 charged particles per pulse.Type: ApplicationFiled: March 10, 2021Publication date: April 27, 2023Applicant: HIL Applied Medical, Ltd.Inventors: Evgeny Papeer, Alex BESPALI, Sagi Brink-Danan, Pavel Komm, Raphael Van Roermund, Indranuj Dey
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Patent number: 11501943Abstract: Disclosed are systems and methods for generating a beam of charged particles, such as an ion beam. Such a system may comprise an interaction chamber configured to support a target, one or more electromagnetic radiation sources, a sensor, and at least one processor. The one or more electromagnetic radiation sources may be configured to provide a probe beam at a first energy for determining orientation data of the target and a particle-generating beam at a second energy, which is greater than the first energy, for producing a beam of charged particles. The processor may be configured to receive feedback information from the sensor and to cause a change in a relative orientation between the particle-generating beam and the target.Type: GrantFiled: July 9, 2019Date of Patent: November 15, 2022Assignee: HIL Applied Medical, Ltd.Inventors: Indranuj Dey, Evgeny Papeer, Alexander Bespaly, Shai Tsipshtein, Ynon Hefets, Assaf Shaham
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Patent number: 10847340Abstract: Systems for directing a pulsed beam of charged particles include an ion source configured to produce a pulsed ion beam that includes at least one ion bunch. Such systems include an electromagnet for producing an electromagnetic field through which the pulsed ion beam travels, and an automated switch that selectively activates the electromagnet. A source of radiation triggers the automated switch, and at least one processor is configured to activate the electromagnet as the ion bunch traverses the electromagnetic field. Such systems may be useful, for example, for filtering a pulsed ion beam to select ions falling within a desired energy range and/or for providing pulsed ion radiation at desired times.Type: GrantFiled: October 11, 2017Date of Patent: November 24, 2020Assignee: HIL APPLIED MEDICAL, LTD.Inventors: Evgeny Papeer, Assaf Shaham, Shmuel Eisenmann, Yair Ferber, Ynon Hefets, Omer Shavit, Boaz Weinfeld, Sagi Brink-Danan
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Patent number: 10395881Abstract: Systems for generating a proton beam include an electromagnetic radiation beam (e.g., a laser) that is directed onto an ion-generating target by optics to form the proton beam. A detector is configured to measure a laser-target interaction property, which a processor uses to produce a feedback signal that can be used to alter the proton beam by adjusting the source of the electromagnetic radiation beam, the optics, or a relative position or orientation of the electromagnetic radiation beam to the ion-generating target. By adjusting the laser-target interaction, the feedback can be used to control properties of the proton beam, such as the proton beam energy or flux. Such systems have certain advantages, including reducing the size, complexity, and cost of machines used to generate proton beams, while also improving their speed, precision, and configurability.Type: GrantFiled: October 11, 2017Date of Patent: August 27, 2019Assignee: HIL APPLIED MEDICAL, LTD.Inventors: Evgeny Papeer, Assaf Shaham, Shmuel Eisenmann, Yair Ferber, Ynon Hefets, Omer Shavit, Boaz Weinfeld, Sagi Brink-Danan
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Patent number: 10076675Abstract: Laser accelerated Proton beams provides compact sources for Proton beams. This invention describes several examples of optic designs which provide a compact beam delivery system capable of supporting pencil beam scanning and delivering the required clinical dosage in a tight beam spot.Type: GrantFiled: September 26, 2016Date of Patent: September 18, 2018Assignee: HIL Applied Medical Ltd.Inventors: Carol Johnstone, Shmulik Eisenmann, Sagi Brink-Danan
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Patent number: 10039935Abstract: Systems for treating a patient using protons include a proton source configured to provide a proton beam having a plurality of proton energies and at least one processor. The at least one processor is configured to control relative movement between the proton beam and the patient in two dimensions, and to control the proton energy distribution to adjust the penetration depth of the protons in the third dimension while maintaining substantially fixed coordinates in the other two dimensions. Such treatment systems allow for shorter treatment times, higher patient throughput, more precise treatment of the desired areas, and less collateral damage to healthy tissue.Type: GrantFiled: October 11, 2017Date of Patent: August 7, 2018Assignee: HIL Applied Medical, Ltd.Inventors: Evgeny Papeer, Assaf Shaham, Shmuel Eisenmann, Yair Ferber, Ynon Hefets, Omer Shavit, Boaz Weinfeld, Sagi Brink-Danan
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Patent number: 9937360Abstract: Systems for generating a proton beam include an electromagnetic radiation beam (e.g., a laser) that is directed onto an ion-generating target by optics to form the proton beam. At least one processor is configured to control the source of the electromagnetic radiation and the optics to alter the energy, polarization, spatial profile, and/or the temporal profile of the electromagnetic radiation beam, and to adjust the flux and/or energy of the proton beam. In some instances the system may adjust the proton beam energy while holding the proton beam flux substantially constant, or alternatively adjust the proton beam flux while holding the proton beam energy substantially constant. In other instances the system may adjust the proton beam energy while varying the proton beam flux, and/or adjust the proton beam flux while varying the proton beam energy.Type: GrantFiled: October 11, 2017Date of Patent: April 10, 2018Assignee: HIL Applied Medical, Ltd.Inventors: Evgeny Papeer, Assaf Shaham, Shmuel Eisenmann, Yair Ferber, Ynon Hefets, Omer Shavit, Boaz Weinfeld, Sagi Brink-Danan
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Patent number: 9711319Abstract: The present invention discloses a system and method for generating a beam of fast ions. The system comprising: a target substrate having a patterned surface, a pattern comprising nanoscale pattern features oriented substantially uniformly along a common axis; and; a beam unit adapted for receiving a high power coherent electromagnetic radiation beam and providing an electromagnetic radiation beam having a main pulse and a pre-pulse and focusing it onto said patterned surface of the target substrate to cause interaction between said radiation beam and said substrate enabling creation of fast ions.Type: GrantFiled: August 16, 2016Date of Patent: July 18, 2017Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD., HIL APPLIED MEDICAL LTD.Inventors: Arie Zigler, Shmuel Eisenmann, Tala Palchan, Sagi Brink-Danan, Eyal Gad Nahum
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Patent number: 9530605Abstract: A system for generating pulses of charged particles, comprising a high intensity pulsed laser emitting laser pulses which, when impacting a target, generate pulses of charged particles. The particles passes through an electromagnet energized by a low inductance current feed incorporating a light activated switch to turn the energizing current on and off. Part of the light of the laser pulse is directed onto the light activated switch, such that the magnetic field is optically synchronized with the generated pulses of charged particles. This enables energizing the magnet only during passage of the pulses, such that it is lighter and more energy efficient than prior art systems using CW electromagnets. Synchronization also enables selection of charged particles having a predetermined range of particle energy, by timing activation of the magnetic field such that it diverts onto a selected beam path only the particles having the predetermined range of energies.Type: GrantFiled: January 31, 2013Date of Patent: December 27, 2016Assignee: HIL APPLIED MEDICAL LTD.Inventors: Eyal Gad Nahum, Shmuel Eisenmann, Arie Zigler, Sagi Brink-Danan, Yiftach Katzir
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Patent number: 9455113Abstract: The present invention discloses a system and method for generating a beam of fast ions. The system comprising: a target substrate having a patterned surface, a pattern comprising nanoscale pattern features oriented substantially uniformly along a common axis; and; a beam unit adapted for receiving a high power coherent electromagnetic radiation beam and providing an electromagnetic radiation beam having a main pulse and a pre-pulse and focusing it onto said patterned surface of the target substrate to cause interaction between said radiation beam and said substrate enabling creation of fast ions.Type: GrantFiled: December 9, 2015Date of Patent: September 27, 2016Assignees: HIL Applied Medical, Ltd., Yissum Research Development Company Of The Hebrew University Of Jerusalem LTD.Inventors: Arie Zigler, Shmuel Eisenmann, Tala Palchan, Sagi Brink-Danan, Eyal Gad Nahum
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Patent number: 9236215Abstract: The present invention discloses a system and method for generating a beam of fast ions. The system comprising: a target substrate having a patterned surface, a pattern comprising nanoscale pattern features oriented substantially uniformly along a common axis; and; a beam unit adapted for receiving a high power coherent electromagnetic radiation beam and providing an electromagnetic radiation beam having a main pulse and a pre-pulse and focusing it onto said patterned surface of the target substrate to cause interaction between said radiation beam and said substrate enabling creation of fast ions.Type: GrantFiled: January 29, 2013Date of Patent: January 12, 2016Assignees: HIL Applied Medical, Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem, LTD.Inventors: Arie Zigler, Shmuel Eisenmann, Tala Palchan, Sagi Brink-Danan, Eyal Gad Nahum
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Publication number: 20130153783Abstract: The present invention discloses a system and method for generating a beam of fast ions. The system comprising: a target substrate having a patterned surface, a pattern comprising nanoscale pattern features oriented substantially uniformly along a common axis; and; a beam unit adapted for receiving a high power coherent electromagnetic radiation beam and providing an electromagnetic radiation beam having a main pulse and a pre-pulse and focusing it onto said patterned surface of the target substrate to cause interaction between said radiation beam and said substrate enabling creation of fast ions.Type: ApplicationFiled: January 29, 2013Publication date: June 20, 2013Applicants: HIL Applied Medical Ltd., Yissum Research Development Company of the Hebrew University of Jersusalem Ltd.Inventors: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., HIL Applied Medical Ltd.