Patents Assigned to Hipep Laboratories
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Publication number: 20220041656Abstract: Disclosed are a novel compound having a higher angiogenic effect than that of a known peptide-based angiogenic agent, and an angiogenic agent including the novel compound. The compound is represented by the following formula [1]: Cyclic(Cys-O2Oc-SVV(F/Y)GLRG-Cys)-NH2 (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), the following formula [II]: Cyclic(O2Oc-SVV(F/Y)GLRQ)-NH2 [II] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), or the following formula [III]: O2Oc-SVV(F/Y)GLR-NH2 [III] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6).Type: ApplicationFiled: October 31, 2019Publication date: February 10, 2022Applicant: HiPep LaboratoriesInventors: Kiyoshi NOKIHARA, Yuki TOMINAGA, Atsushi KITAGAWA, Shun NOKIHARA
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Patent number: 9857369Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.Type: GrantFiled: July 22, 2014Date of Patent: January 2, 2018Assignees: HIPEP LABORATORIES, NIPPON LIGHT METAL COMPANY, LTD.Inventors: Kiyoshi Nokihara, Akiyoshi Hirata, Yasuo Oka, Yasushi Takebayashi
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Patent number: 9778256Abstract: A biochip substrate which is free from cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same. A biochip substrate on which multiple valleys for immobilizing biological substances are formed so as to prevent cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same are provided. Moreover, it is found out that a desired binding in a target molecule contained in a test sample occurs at a detectable level in a solution system even in the case where a valley have such a small capacity as 1 nL to 10 nL.Type: GrantFiled: June 16, 2006Date of Patent: October 3, 2017Assignees: HIPEP LABORATORIES, NIPPON LIGHT METAL COMPANY, LTD.Inventors: Kiyoshi Nokihara, Yasuo Oka
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Publication number: 20140336081Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.Type: ApplicationFiled: July 22, 2014Publication date: November 13, 2014Applicants: NIPPON LIGHT METAL COMPANY, LTD., HIPEP LABORATORIESInventors: Kiyoshi NOKIHARA, Akiyoshi HIRATA, Yasuo OKA, Yasushi TAKEBAYASHI
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Patent number: 8822607Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.Type: GrantFiled: June 30, 2009Date of Patent: September 2, 2014Assignees: Hipep Laboratories, Nippon Light Metal Company, Ltd.Inventors: Kiyoshi Nokihara, Akiyoshi Hirata, Yasuo Oka, Yasushi Takebayashi
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Patent number: 8455400Abstract: A substrate for biochips with which immobilization is easy, which does not exhibit self-fluorescence, which is easy to manufacture, and which is excellent in flatness and surface precision, is disclosed. A substrate having a substrate body of the biochip, which is made of a metal, and a carbon layer having functional groups formed on the metal substrate body is used as a substrate for biochips. Since the substrate body of the substrate for biochips is made of a metal, the substrate is not only easy to manufacture, but also free from cracking and chipping, so that it allows easy handling, and high flatness and surface precision can be attained. Therefore, the problem that the optical system is hard to focus when detecting fluorescence does not occur. Moreover, since the substrate body is made of a metal, it does not emit fluorescence by itself. In addition, since the carbon layer has functional groups such as amino groups, biologically relevant substances can be easily immobilized.Type: GrantFiled: May 24, 2006Date of Patent: June 4, 2013Assignees: Hipep Laboratories, Nippon Light Metal Company, Ltd.Inventors: Kiyoshi Nokihara, Yasuo Oka
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Patent number: 8148141Abstract: Disclosed is a peptide-immobilized substrate for measuring a target protein, with which the peptide can have a structure required for being recognized by the target protein, with which the accurate loading amount of the peptide can be attained, and by which a trace amount of the target protein may be measured accurately and simply. The peptide-immobilized substrate for measuring a target protein according to the present invention comprises a chemically synthesized peptide having an expected spatial structure or having a binding ability with the target protein, which peptide can bind with the target protein and is immobilized on the substrate.Type: GrantFiled: May 7, 2002Date of Patent: April 3, 2012Assignee: HiPep LaboratoriesInventors: Kiyoshi Nokihara, Hisakazu Mihara
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Patent number: 8057743Abstract: Means for overcoming the problems which the conventional glass microchannel chips have are disclosed. That is, a microchannel chip in which microchannels can be formed at a low cost, and which has a high chemical resistance is disclosed. The microchannel chip is constituted by a substrate made of carbon, which has a channel in its surface; and a cover composed of a glass plate bonded to the substrate. The cover is bonded to the substrate by heating at least a part of the contact surface at which the substrate is in contact with the cover.Type: GrantFiled: June 13, 2008Date of Patent: November 15, 2011Assignees: Hipep Laboratories, Nippon Light Metal Company, Ltd.Inventors: Kiyoshi Nokihara, Yasuo Oka