Patents Assigned to HIROTSU BIO SCIENCE INC.
  • Publication number: 20230408496
    Abstract: The present invention provides a method for analyzing a blood sample. According to the present invention, there is provided, for example, a method for testing or analyzing a blood sample from a subject having cancer or suspected of having cancer, including evaluating taxis behavior of nematodes to the blood sample. According to the present invention, there is provided, for example, a method for evaluating whether a subject has cancer or not by the above method.
    Type: Application
    Filed: November 16, 2021
    Publication date: December 21, 2023
    Applicant: Hirotsu Bio Science Inc.
    Inventor: Takaaki HIROTSU
  • Patent number: 11725226
    Abstract: The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: August 15, 2023
    Assignees: HIROTSU BIO SCIENCE INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Takaaki Hirotsu, Hirofumi Jono
  • Patent number: 11719698
    Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: August 8, 2023
    Assignee: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki Hirotsu, Hideto Sonoda
  • Publication number: 20230204590
    Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
    Type: Application
    Filed: March 9, 2023
    Publication date: June 29, 2023
    Applicant: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki HIROTSU, Hideto SONODA
  • Publication number: 20230020220
    Abstract: A taxis analysis method for performing taxis analysis of nematodes using a container in which a reference point is provided in the container or a culture medium in the container, the taxis analysis method including steps of: imaging a distribution mode of the nematodes in the container after the nematodes and a specimen of a subject are dropped into the container; detecting a position of an object of the reference point corresponding to the reference point included in the image obtained by imaging; determining an attraction region and a avoidance region on the basis of the position; and executing taxis analysis using objects of the nematodes in the determined attraction region and avoidance region.
    Type: Application
    Filed: December 3, 2020
    Publication date: January 19, 2023
    Applicant: HIROTSU BIO SCIENCE INC.
    Inventors: Yuki IMAIZUMI, Kenji IWAO
  • Patent number: 11479800
    Abstract: The present invention provides a method for detecting cancer using a tissue specimen. Specifically, for example, there is provided a method for detecting cancer in an organ or tissue having cancer, comprising: preparing a cell lysate from a region suspected to be cancer isolated from the organ or tissue; and evaluating a tactic behavior of a nematode for the cell lysate.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: October 25, 2022
    Assignees: HIROTSU BIO SCIENCE INC., NANPUH HOSPITAL
    Inventors: Takaaki Hirotsu, Takuma Yoshinaga
  • Publication number: 20210356470
    Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
    Type: Application
    Filed: April 27, 2021
    Publication date: November 18, 2021
    Applicant: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki HIROTSU, Hideto SONODA
  • Patent number: 11150234
    Abstract: The present invention provides a method for evaluating the taxic behavior of nematodes in response to an odor substance based on olfactory sense, and a dish and a behavior evaluation system to be used for the evaluation method. [Solution] Provided is a method for evaluating the taxic behavior of nematodes in response to odor of a test sample, the method including: a) providing a dish in which the test sample is arranged on the bottom surface, and nematodes are arranged in a region or a site of the bottom surface 1 cm to 3 cm away from the test sample; b) observing the arrangement of the nematodes on the bottom surface at 3 to 15 minutes after the later one of the test sample or the nematodes is arranged; and c) evaluating whether the nematodes show attraction behavior or avoidance behavior in response to the test sample, from the arrangement of the nematodes observed, and a dish or a taxic behavior evaluation system suitable for the method.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: October 19, 2021
    Assignee: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki Hirotsu, Takayuki Uozumi, Satoru Kaifuchi
  • Publication number: 20210215669
    Abstract: A method of examining for cancer in a non-primate mammal such as a pet animal may include, for example, a method of examining or diagnosing for cancer in a non-primate mammal, including evaluating taxic behavior of nematodes toward a urine sample from a subject mammal.
    Type: Application
    Filed: August 14, 2019
    Publication date: July 15, 2021
    Applicant: Hirotsu Bio Science Inc.
    Inventors: Takaaki HIROTSU, Satoru KAIFUCHI, Toshimi SUGIMOTO, Hideshi ISHII, Masamitsu KONNO, Yuji UEDA, Shogo KOBAYASHI, Hidetoshi EGUCHI, Yuichiro DOKI, Masaki MORI
  • Publication number: 20200400653
    Abstract: The present invention provides a method for predicting a therapeutic effect and/or monitoring recurrence in a cancer patient. Disclosed is a method for detecting a therapeutic effect of cancer treatment in a cancer patient, comprising: measuring nematode tactic behavior to each of pre-treatment urine and in-treatment or post-treatment urine from the cancer patient; and comparing a result of measuring the tactic behavior to the pre-treatment urine and a result of measuring the tactic behavior to the in-treatment or post-treatment urine, wherein when attraction is weakened or avoidance is strengthened after the treatment, it is determined that the therapeutic effect is detected.
    Type: Application
    Filed: March 30, 2018
    Publication date: December 24, 2020
    Applicants: HIROTSU BIO SCIENCE INC., NANPUH HOSPITAL
    Inventor: Takaaki HIROTSU
  • Publication number: 20200208192
    Abstract: The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.
    Type: Application
    Filed: August 20, 2018
    Publication date: July 2, 2020
    Applicants: HIROTSU BIO SCIENCE INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Takaaki HIROTSU, Hirofumi JONO
  • Publication number: 20200165655
    Abstract: The present invention provides a method for detecting cancer using a tissue specimen. Specifically, for example, there is provided a method for detecting cancer in an organ or tissue having cancer, comprising: preparing a cell lysate from a region suspected to be cancer isolated from the organ or tissue; and evaluating a tactic behavior of a nematode for the cell lysate.
    Type: Application
    Filed: July 10, 2018
    Publication date: May 28, 2020
    Applicants: HIROTSU BIO SCIENCE INC., NANPUH HOSPITAL
    Inventors: Takaaki HIROTSU, Takuma YOSHINAGA
  • Publication number: 20190369084
    Abstract: The present invention provides a method for evaluating the taxic behavior of nematodes in response to an odor substance based on olfactory sense, and a dish and a behavior evaluation system to be used for the evaluation method. [Solution] Provided is a method for evaluating the taxic behavior of nematodes in response to odor of a test sample, the method including: a) providing a dish in which the test sample is arranged on the bottom surface, and nematodes are arranged in a region or a site of the bottom surface 1 cm to 3 cm away from the test sample; b) observing the arrangement of the nematodes on the bottom surface at 3 to 15 minutes after the later one of the test sample or the nematodes is arranged; and c) evaluating whether the nematodes show attraction behavior or avoidance behavior in response to the test sample, from the arrangement of the nematodes observed, and a dish or a taxic behavior evaluation system suitable for the method.
    Type: Application
    Filed: September 11, 2017
    Publication date: December 5, 2019
    Applicant: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki HIROTSU, Takayuki UOZUMI, Satoru KAIFUCHI