Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 ?m, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 ?m or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.

Abstract: A microneedle array in accordance with one embodiment comprises at least a first microneedle and a second microneedle that are inclined with respect to a support face. A tip of the first microneedle points in a first direction, and a tip of the second microneedle points in a second direction different from the first direction. The first microneedle in contact with skin is stuck into the skin while being moved along a surface of the skin in the first direction. The second microneedle in contact with the skin is stuck into the skin while being moved along the surface of the skin in the second direction.

Abstract: A pressure-sensitive adhesive tape package is described in which while easiness in applying the adhesive tape is pursued, an effect of saving in resources can be obtained. The pressure-sensitive adhesive tape package accommodates an adhesive tape having a support and an adhesive agent layer provided on one surface of the support, and includes a release sheet releasably attached to the adhesive agent layer. Moreover, in the pressure-sensitive adhesive tape package, the release sheet is bent along a predetermined bending line with the adhesive tape, and the adhesive tape is sealed inside of the bent release sheet.

Abstract: A patch has a backing which has been subjected to an ultraviolet-screening processing, the backing usually being of one layer. The ultraviolet-screening processing usually uses an organic ultraviolet absorbent and/or an inorganic ultraviolet-screening agent. The patch can contain in its base a medicine of poor photo-stability and a non-steroidal anti-inflammatory analgesic.

Abstract: A plaster comprising a styrene-isoprene-styrene block copolymer 10-40 wt %, a rosin-based resin 5-30 wt %, a plasticizer 20-70 wt %, polyisobutylene 6-40 wt %, an antioxidant 0.1-5 wt %, and felbinac as a medicinally effective component 1.1-10 wt %, wherein the plaster does not contain crotamiton which is a solubilizer for the felbinac, the felbinac is uniformly dispersed in a semi-solubilized state in the plaster, wherein solubilized felbinac and microcrystalline felbinac coexist in the plaster, and a thickness of the plaster is 50-300 ?m.

Abstract: Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.

Abstract: Medicinal compositions having an effect of regulating the activation of glycine receptor and novel morphan derivatives. Medicinal compositions comprising morphan derivatives or its salts and a pharmaceutically acceptable carrier. These compositions potentiate or inhibit the activation of glycine receptor, which makes them useful as drugs for the central nervous system. Novel 1- and/or 2-substituted morphan derivatives (2-azabicyclo[3.3.1]nonane derivatives) or salts thereof.

Abstract: Physiologically active peptides possessing cell adhesion inhibitory activity are provided. A physiologically active peptide of this invention is characterized by possessing cell adhesion inhibitory activity and comprising 30 amino acid residues or less, as well as by having an amino acid sequence of the formula: Gly Leu Lys Pro Gly Val Asp X1 Thr Ile Thr X2 X3 Ala X4 wherein X1 represents Tyr or Ala; X2 represents Val or Ala; X3 represents Tyr or Ala; and X4 represents Val or Ala.

Abstract: The object of the present invention is to provide an iontophoresis electrode device with superior performance which avoids entrance of metal ions from the electrode into the body, is reusable and can be mass produced at low cost, minimizes gas generation which causes polarization, can notably improve transport current, and can prevent skin injury by pH changes during prolonged application. The iontophoresis electrode device of the present invention has a construction provided with a backing 1 having an edge section 1a around an opening and a packing chamber 4 inside, an electrode terminal 2 situated in the packing chamber 4, a non-adhesive gel 5 containing an electrolyte solvent, depolarizer, pH regulator and drug packed in the packing chamber 4, an inert electrode member 3 covering the base of the electrode terminal 2, and a liner 7 attached to the adhesive layer 6 coated on the edge section 1a and covering the opening.

Abstract: A transdermal patch which comprises: a substrate sheet comprises a composite film formed of a resin composition comprising 100 parts by weight of a polyvinyl chloride-polyurethane composite and 2-10 parts by weight of a styrene-ethylene-butylene-styrene copolymer, a first adhesive layer on the one side of the composite film, and a polyalkylene terephthalate film adhered to the one side of the composite film by means of the first adhesive layer, a primer layer which comprises a saturated polyester resin and is formed on the surface of the polyalkylene terephthalate film; and a second adhesive layer comprising a styrene-diene-styrene block copolymer containing a pharmaceutical agent layered on the primer layer.

Abstract: It is the object of the present invention to provide an iontophoresis device structure which has excellent contouring ability at its site of attachment, has very high safety, is of high quality with high product yields, and can be produced with fewer production steps to improve working efficiency and increase productivity to allow mass production at low cost. The iontophoresis device structure of the present invention has a construction provided with a cup-shaped support including a concave part, at least one electrification hole formed in the concave part, an electrode layer laid on the flat part of the rim of the concave part, and an electrolyte layer or drug-holding layer fitted into the concave part.

Abstract: An iontophoresis system and its control process for current are proposed, which system can decrease variation in drug delivery quantity due to the individual difference of impedance of skin or mucosal membrane, and avoid any decrease of the delivery quantity of drug in a donor device, thereby to obtain excellent medicinal effect, safety, reliability, and productivity, comprising said donor device, a reference device, a current detection unit for measuring as an effective current value the difference between the value of an applied current passing between the donor and reference devices during application of pulse voltage/current and the value of a discharged current whose electric charge which the living body has been equipped with is released by a short-circuit formed between said donor and reference devices when the application of pulse voltage/current is suspended, and a feedback control unit of making the amplitude of the pulse voltage/current variable to control the effective current value.

Abstract: An iontophoresis electrode structure comprising has both a polarization electrode and a non-polarization electrode, wherein both electrodes can be switched freely while the electricity is turned on. The present electrode structure makes it possible to transfer biologically active substances and drugs into a living body through the skin and the mucous membrane in a sufficient amount and safety by employing both a polarization electrode and a non-polarization electrode as iontophoresis electrodes according to a proper switch, and can transfer biologically active substances and drugs through the skin and the mucous membrane effectively without causing irritation.

Abstract: A matrix type patch formulation which comprises an adhesive layer containing a physiological active substance, an organic acid, a hydrophobic high molecular material, a tackifying resin, a plasticizer and an absorption enhancer, is disclosed. The adhesive layer preferably contains 0.1 to 20% (w/w) of the physiological active substance, 0.01 to 15% (w/w) of the organic acid, 15 to 60% (w/w) of the hydrophobic high molecular material, 10 to 70% (w/w) of the tackifying resin, 10 to 60% (w/w) of the plasticizer and 0.01 to 20% (w/w) of the absorption enhancer. The organic acid is preferably an aliphatic carboxylic acid, an aromatic carboxylic acid, an alkyl sulfonic acid, an alkyl sulfonic acid derivative, cholic acid derivative or a water-soluble inorganic salt thereof. The matrix type patch formulation of the present invention can increase the percutaneous absorbability of the physiological active substance and is extremely reduced in skin irritation.