Abstract: An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular cartilage or bone, using the acellular matrix implant implanted into a joint cartilage lesion in situ and a bone-inducing composition implanted into an osteochondral or bone defect. A method for repair and restoration of the injured, damaged, diseased or aged cartilage or bone into its full functionality by implanting the acellular matrix implant between two layers of biologically acceptable sealants and/or the bone-inducing composition into the osteochondral bone or skeletal bone defect. A method for fabrication of the acellular matrix implant of the invention. A method for preparation of bone-inducing composition.
Type:
Grant
Filed:
June 30, 2004
Date of Patent:
May 15, 2007
Assignee:
Histogenics Corp.
Inventors:
Akihiko Kusanagi, Laurence J. B. Tarrant, Mary Beth Schmidt
Abstract: A method for repair of meniscal injuries comprising induction of meniscal regeneration by introducing a strongly adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury.
Type:
Grant
Filed:
November 26, 2004
Date of Patent:
January 2, 2007
Assignee:
Histogenics, Corp.
Inventors:
Akihiko Kusanagi, Mary Beth Schmidt, Laurence J. B. Tarrant
Abstract: The present invention relates to compositions and methods for preparing tissues or tissue constructs. In selected embodiments, the invention relates to the construction of a multi-layered biological structure (i.e. system) that includes a cellular support matrix seeded with living cells derived from a native tissue. The present invention also relates to tissue culture protocols to promote the in vitro growth of tissues and tissue constructs.
Type:
Grant
Filed:
March 22, 2002
Date of Patent:
September 27, 2005
Assignee:
Histogenics, Corp.
Inventors:
Shuichi Mizuno, Toshimasa Tokuno, Laurence J. Berlowitz Tarrant