Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.

Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.

Abstract: The present relates to a positioning and shaping shell manufacturing method for manufacturing a positioning and shaping shell comprising a positioning step consisting in positioning and supporting a target body portion with a transparent body shaper in a predetermined position on a positioning board presenting at least one transparent portion permitting scanning through it, an image acquisition step consisting in a target body portion surface scan imaging also via the transparent portion of the board and said transparent body support, a software computing step where the acquired image data are sent and processed in a processing unit, and a producing step consisting in producing a 3D positioning and shaping shell model via additive or subtractive manufacturing method based in the processed image data.

Abstract: The present invention provides methods of inhibiting cerebral inflammation comprising administering a CCR5 inhibitor to a subject.

Abstract: The present invention relates to new BARD1 isoforms specific to lung cancer and colorectal cancer, a method for detecting thereof and a method for treating and/or preventing lung cancer and colorectal cancer.

Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.

Abstract: The present invention is directed to N-desmethylclobazam or any suitable pharmaceutically acceptable thereof useful for the prevention and/or treatment of a chronic pain disorder and related methods and pharmaceutical formulations.

Abstract: The present invention relates to agents enhancing HuR/ELAV levels for use in the treatment of BRAF-mutated cancers and uses thereof. In particular, the invention relates to the use of agents enhancing HuR/ELAV levels in combination with BRAF inhibitors for the treatment of BRAF-mutated cancers, in particular melanoma and to methods for identifying agents useful for potentiating the effects of BRAF inhibitors, when used in combination.

Abstract: The invention relates to mimetic peptides of epitope(s) of Apolipoprotein A-I, diagnostic immunoassays comprising such mimetic peptides, as well as methods for diagnosing and methods for preventing and/or treating a cardiovascular disease.

Abstract: Implant for transfemoral or transtibial amputation comprising a stem (3) and a base (2), the base (2) comprising a bone support surface (4) on one side and on an opposite side a soft tissue load bearing surface (5). The stem extends from the base perpendicular to the bone support surface and is configured for insertion in a medullary canal (23) of an amputated bone (20), the bone support surface (4) being configured for abutment against a severed end (22) of said amputated bone. A diameter (d1) of the base is configured to be larger than an average diameter of a shaft (21) of said severed bone, the soft tissue load bearing surface (5) comprising a generally planar or slightly curved central portion (10) and a convexly curved radially outward portion (11) with a curvature greater than the central portion, the central portion (10) being oriented at an angle of between 4° to 8° to the bone support surface.

Abstract: The present invention relates to new BARD1 isoforms specific to lung cancer and colorectal cancer, a method for detecting thereof and a method for treating and/or preventing lung cancer and colorectal cancer.

Abstract: The present invention relates to a short cell penetrating peptide derived from the Epstein-Barr virus basic leucine zipper transcriptional activator (ZEBRA), optionally linked to a cargo molecule. It also relates to a complex comprising the cell penetrating peptide and a cargo molecule, as well as cells loaded with the complex and the use thereof in therapy and diagnosis.

Abstract: The present invention relates to new BARD1 isoforms specific to lung cancer and colorectal cancer, a method for detecting thereof and a method for treating and/or preventing lung cancer and colorectal cancer.

Abstract: A device for electrical stimulation of neural and/or muscular tissue. The device includes a cochlear implant being equipped with a power source, a speech processor, a microphone adapted to deliver sound signals to said speech processor, a current stimulator, at least an array of electrodes attached to the stimulator, and at least a signal sensor other than the microphone. The device further includes a signal transformation unit, said signal sensors being adapted to capture relevant input information and to deliver a corresponding input signal to the transformation unit, the latter allowing to transform said input signal received from the signal sensors into a modulated electrical output signal adapted to be treated by the speech processor of the cochlear implant.

Abstract: A device for electrical stimulation of neural and/or muscular tissue. The device includes a cochlear implant being equipped with a power source, a speech processor, a microphone adapted to deliver sound signals to said speech processor, a current stimulator, at least an array of electrodes attached to the stimulator, and at least a signal sensor other than the microphone. The device further includes a signal transformation unit, said signal sensors being adapted to capture relevant input information and to deliver a corresponding input signal to the transformation unit, the latter allowing to transform said input signal received from the signal sensors into a modulated electrical output signal adapted to be treated by the speech processor of the cochlear implant.

Abstract: The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4+ epitope; and (iii) at least one CD8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases.

Abstract: The present invention relates to a short cell penetrating peptide derived from ZEBRA, optionally linked to a cargo molecule. It also relates to a complex comprising said cell penetrating peptide and a cargo molecule, as well as cells loaded with said complex and the use thereof in therapy and diagnosis.

Abstract: Dynamic external fixator comprising a pair of rods (1) made of a radiolucent material, each rod (1) comprising a base (10), preferably with an opening (13), a stem (11) extending from the base (10), with a sliding groove (14) extending along a longitudinal axis of the stem (11); and stopping means (12, 2) between the base (10) and the stem (11); a pair of springs (3), each spring (3) being arranged on the stem (11) of one of the rods (1) and abutting against the stopping means (12, 2); proximal attachment means (K1) for attaching the base (10) of each rod (1) to a first position; distal attachment means (K2) for attaching the stem (11) of each rod (1) to a second position, wherein the distal attachment means (K2) are inserted into the spirals of the spring (3) and through the sliding groove (14) of each of the rods (1), such that turning the spring (3) around the stem (11) allows adjusting a distraction force between the proximal attachment means (K1) and the distal attachment means (K2); and method for attac

Abstract: The present invention relates to the compounds useful in the prevention and/or treatment of tumors. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumors presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumor glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention.

Abstract: An apparatus for the treatment and/or prevention of corneal diseases includes an applicator head. The applicator head includes a radiation source capable of exciting a non-toxic chromophore. A control is operable to activate the radiation source to radiate, wherein at least one of the following two conditions is met: the applicator head includes a sensor capable of measuring a signal dependent on a position of the applicator head relative to the cornea; or, the applicator head is configured to be in physical contact with the cornea. The control is operable to activate the radiation source to radiate depending on a signal measured by the sensor or to activate the radiation source when the applicator head touches the cornea, respectively.