Abstract: Methods, systems and techniques for the accurate measurement breath-borne biomarkers are disclosed. Such methods, systems and techniques may be used for the purposes of detection and/or measurement in breath samples of biomarkers.
Type:
Grant
Filed:
March 18, 2020
Date of Patent:
May 7, 2024
Assignee:
Hound Labs, Inc.
Inventors:
Michael Scott Lynn, Joseph A. Heanue, Samartha G. Anekal, Kevin M. Limtao, Kevin Bradford Dunk, Jeffrey A. Schuster, Jeffrey A. Stoll
Abstract: The present disclosure relates to using Surface-Enhanced Raman Spectroscopy (SERS) for detecting analytes in samples. Uses can include, for example, detection of tetrahydrocannabinol (THC) using SERS, as well as apparatuses and systems to implement such detection methods.
Type:
Grant
Filed:
May 12, 2021
Date of Patent:
March 19, 2024
Assignee:
Hound Labs, Inc.
Inventors:
Jeffrey A. Stoll, Samartha G. Anekal, Karan Mohan
Abstract: An example breath collection and sampling device disclosed herein comprises a cartridge housing having a breath capture module, and a rotary valve operatively coupling a mouthpiece with the breath capture module. The rotary valve can have an open position where breath of a user can pass through the rotary valve, across capture sites of the breath capture module, and into a vacuum port, and a closed position for sealing the breath capture module from fluid passing through the rotary valve, while allowing the breath capture module to be exposed to a reagent for subsequent analysis of contents within the captured breath.
Type:
Grant
Filed:
August 25, 2022
Date of Patent:
February 6, 2024
Assignee:
Hound Labs, Inc.
Inventors:
Michael Scott Lynn, Joseph A. Heanue, Kevin M. Limtao, Jeffrey A. Schuster, Peter A. Holst
Abstract: Methods, systems and techniques for the accurate measurement of breath-borne biomarkers are disclosed. Such methods, systems and techniques may be used for the purposes of detection and/or measurement in breath samples of biomarkers, e.g., biomarkers relating to a disease or a physiological condition.
Type:
Grant
Filed:
January 29, 2020
Date of Patent:
November 21, 2023
Assignee:
Hound Labs, Inc.
Inventors:
Michael Scott Lynn, Joseph A. Heanue, Samartha G. Anekal, Kevin M. Limtao, Kevin Bradford Dunk, Jeffrey A. Schuster, Jeffrey A. Stoll
Abstract: Various fluidic structures are described that may be implemented between two portions of material, at least one of which may be made of a flexible but inelastic material, such as Mylar. Such fluidic circuits may be configured such that applying a clamping pressure zone to such fluidic circuits and then moving the clamping pressure zone along the fluidic circuit and along a particular axis may cause the fluidic circuit to operate in a particular manner, thereby driving fluids contained within the fluidic circuit around the fluidic circuit according to a desired flow sequence.
Type:
Grant
Filed:
January 12, 2022
Date of Patent:
November 7, 2023
Assignee:
Hound Labs, Inc.
Inventors:
Daniel H. Friedman, Michael V. D'Ambrosio, William Welch, Thu M. Nguyen
Abstract: Methods and devices for sampling, processing and identifying use of a substance or substances of abuse are provided. Systems and kits for sampling, processing and identifying acute use of a substance of abuse is also provided.
Abstract: Methods and devices for sampling, processing and identifying use of a substance or substances of abuse are provided. Systems and kits for sampling, processing and identifying acute use of a substance of abuse is also provided.
Abstract: Methods and devices for sampling, processing and identifying use of a substance or substances of abuse are provided. Systems and kits for sampling, processing and identifying acute use of a substance of abuse is also provided.
Abstract: Methods and devices for sampling, processing and identifying use of a substance or substances of abuse are provided. Systems and kits for sampling, processing and identifying acute use of a substance of abuse is also provided.
Abstract: Provided is a solid-state illumination system for use in a microscopy system utilizing a light sensor of a mobile phone camera module. The system includes a bright-field illumination source with an array of light-emitting diodes (LEDs). The array of LEDs is configured to produce transmission light within a range of view of the light sensor of the mobile phone camera module. The system also includes a dark-field illumination source including a ring of LEDs. The ring of LEDs is configured to produce light outside of the range of collection of the camera module lens. The system also includes a diffuser configured to diffuse the transmission light and a diffusive black material coupled to the diffuser. The diffusive black material is configured to pass through at least some of the transmission light while blocking reflections of the scattering light.
Type:
Grant
Filed:
May 6, 2021
Date of Patent:
December 20, 2022
Assignee:
Hound Labs, Inc.
Inventors:
Daniel H. Friedman, Michael V. D'Ambrosio
Abstract: An example breath collection and sampling device disclosed herein comprises a cartridge housing having a breath capture module, and a rotary valve operatively coupling a mouthpiece with the breath capture module. The rotary valve can have an open position where breath of a user can pass through the rotary valve, across capture sites of the breath capture module, and into a vacuum port, and a closed position for sealing the breath capture module from fluid passing through the rotary valve, while allowing the breath capture module to be exposed to a reagent for subsequent analysis of contents within the captured breath.
Type:
Grant
Filed:
October 16, 2019
Date of Patent:
August 30, 2022
Assignee:
Hound Labs, Inc.
Inventors:
Michael Scott Lynn, Joseph A. Heanue, Kevin M. Limtao, Jeffrey A. Schuster, Peter A. Holst
Abstract: Systems, techniques and compositions can detect and measure a target substance, such as THC, in a constituent sample from exhaled human breath.
Type:
Grant
Filed:
May 16, 2018
Date of Patent:
June 8, 2021
Assignee:
HOUND LABS, INC.
Inventors:
Michael Scott Lynn, Hamilton Roger Tang, Kevin Bradford Dunk, Kevin M. Limtao, Hayuta Jain
Abstract: Methods and devices for sampling, processing and identifying acute use of a substance or substances of abuse are provided. Systems and kits for sampling, processing and identifying acute use of a substance of abuse is also provided.
Abstract: Various embodiments for a hand-held device to determine a level of one or more cannabinoid compounds in exhaled human breath are provided; some embodiments may also determine a level of alcohol in the exhaled breath. The device may perform any of the following steps: capture, concentrate, separate, identify, and quantify the level of cannabinoids in the exhaled human breath. The device may use solvent extraction and liquid chromatography to concentrate and separate cannabinoids from breath contaminants, followed by selective chemical modification of the cannabinoids with a fluorescent indicator for quantification. The measurement methodology may also include real time calibration of the device and detection protocol using known cannabinoid standards, which are simultaneously analyzed along with an unknown, to quantify the level of cannabinoids captured from the breath sample.
Type:
Grant
Filed:
July 14, 2017
Date of Patent:
September 10, 2019
Assignee:
HOUND LABS, INC.
Inventors:
Michael J. Gordon, Louis Chin Jones, Michael Scott Lynn
Abstract: Chemical compositions and methods provide labeling, detection and measurement of target substances in exhaled human breath, and can be implemented in connection with a handheld device—much like a Breathalyzer portable breath testing unit for alcohol—to support rapid quantification of levels of cannabinoid compounds, such as tetrahydrocannabinol (THC), of suspected users at the roadside.
Type:
Grant
Filed:
January 19, 2018
Date of Patent:
April 2, 2019
Assignee:
HOUND LABS, INC.
Inventors:
Michael Scott Lynn, Hamilton Roger Tang, Kate L. Bechtel, Peter A. Holst
Abstract: Methods and devices for sampling, processing and identifying acute use of substance of abuse is provided. Systems and kits for sampling, processing and identifying acute of substance of abuse is also provided.