Abstract: A sample preparation blister pack can include a plurality of reservoirs formed as blisters. The reservoirs can have an actuatable barrier layer and a seal barrier layer with contents of the reservoirs between the actuatable barrier layer and the seal barrier layer. The contents can be to facilitate isolating a biological component from a biological sample. The individual reservoirs can be adapted to release the contents through the seal barrier layer upon actuation of the actuatable barrier layer. The blister pack can have a width and a length and the reservoirs can be lined up along the length. In this example, a first reservoir contains an inert mechanical fluid and a second reservoir contains a reagent, a buffer, or a combination thereof.

Abstract: An example device comprises: a heater; a temperature sensor to monitor changes in temperature caused by the heater; a mechanical device to move the heater between a sample position and a rest position; and a circuit communicatively coupled to the heater, the temperature sensor, and the mechanical device. The circuit is to: control the mechanical device to move the heater to the sample position; control the heater to heat at the sample position; monitor, via the temperature sensor, the temperature; and in response to the temperature meeting a temperature condition, control the mechanical device to move the heater from the sample position to the rest position.

Abstract: A sample preparation cartridge module comprises an input and output; and interconnected volumes arranged in series between the input and output, the volumes comprising a fluidic isolation chamber and an output channel connected to the fluidic isolation chamber downstream of the fluidic isolation chamber and leading to the output.

Abstract: A fluidic device can include interconnected volumes including a bulk fluid volume fluidically connected in series with a capillary volume to receive a density gradient column, a reservoir of a reconstitution buffer positioned outside the interconnected volumes, and a buffer inlet chamber to receive reconstitution buffer from the reservoir of reconstitution buffer. The fluidic device can also include a reactant chamber connected to the buffer inlet chamber by a fluid channel, wherein the reactant chamber contains a reactant, and a reactant injection channel connecting the reactant chamber to the capillary volume to inject the reconstitution buffer and reactant into the capillary volume.