Patents Assigned to Human BioMolecular Research Institute
  • SYNTHETIC COMPOUNDS AND DERIVATIVES AS MODULATORS OF SMOKING OR NICOTINE INGESTION AND LUNG CANCER
    Publication number: 20100298345
    Abstract: Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.
    Type: Application
    Filed: August 2, 2010
    Publication date: November 25, 2010
    Applicant: HUMAN BIOMOLECULAR RESEARCH INSTITUTE
    Inventor: John R. Cashman
  • Synthesis Of Metabolically Stable Analgesics, Pain Medications And Other Agents
    Publication number: 20100190728
    Abstract: Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.
    Type: Application
    Filed: May 31, 2005
    Publication date: July 29, 2010
    Applicant: Human Biomolecular Research Institute
    Inventors: John R. Cashman, James M. MacDougall
  • SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION
    Publication number: 20100159596
    Abstract: Methods and small molecule compounds for stem cell differentiation are provided.
    Type: Application
    Filed: September 16, 2009
    Publication date: June 24, 2010
    Applicants: Burnham Institute for Medical Research, Human BioMolecular Research Institute
    Inventors: Mark Mercola, Marcia Dawson, John Cashman
  • INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION
    Publication number: 20090247520
    Abstract: A method to identify selective inhibitors of antigen receptor-mediated NF-?B activation is provided, as well as compositions having one or more of those inhibitors and methods of using those inhibitors.
    Type: Application
    Filed: March 26, 2009
    Publication date: October 1, 2009
    Applicants: The Burnham Institute for Medical Research, The Human Biomolecular Research Institute
    Inventors: John C. REED, Ranxin SHI, John R. Cashman, Karl J. OKOLOTOWICZ, Daniel RE