Patents Assigned to Human Oltoanyagtermelo es Kutato Intezet
  • Process for the preparation of lyophilized, adsorbed polyvalent vaccines
    Patent number: 4578270
    Abstract: The invention relates to the preparation of lyophilized, absorbed polyvalent vaccines. According to the invention tetanus, diphtheria, pertussis and optionally typhus antigens concentrated to 5 to 15 doses/3 ml are adsorbed at a pH value of 3 to 6 to an insoluble carrier concentrated in the same way as the antigens, then the pH of the mixture is adjusted to a value of 5 to 6 and lyophilized together with a protective material commonly used in lyophilizing processes. Before administration the lyophilized vaccine is diluted to the concentration required by a physiological saline buffered to a pH value of 6.8 to 7 by a phosphate solution.
    Type: Grant
    Filed: February 22, 1984
    Date of Patent: March 25, 1986
    Assignee: Human Oltoanyagtermelo Es Kutato Intezet
    Inventors: Zoltan Csizer, Karoly Sikos, Laszlo Bacskai, Istvan Joo, Eleonora Niedermayer, Lajos Rethy, Jozsef Zsidai
  • Compositions for and medical use of water-soluble derivatives of 6,6-methylene-bis-(2,2,4-trimethyl-1,2-dihydroquinoline)
    Patent number: 4510147
    Abstract: The invention relates to water-soluble alkali salts of mono- and disulfonic acid derivatives and mono- and disulfonamide derivatives of 6,6'-methylene-bis-(2,2,4-trimethyl-1,2-dihydroquinoline) and dimer and/or trimer condensation products thereof bound with a methylene bridge at the 8 or 8' position. The new compounds are radioprotective and radiosensibilizers at the same time, and may be used both in the therapy and prophylaxis of malignant tumors.
    Type: Grant
    Filed: May 14, 1982
    Date of Patent: April 9, 1985
    Assignees: Material Vegyipari Szovetkezet, Human Oltoanyagtermelo Es Kutato Intezet
    Inventors: Vilmos Bar, Jozsef Boszormenyi, Peter Richter, Jeno Mercz, Tamas Rozsnyai
  • Process for preparing lipoid-biologically active particles
    Patent number: 4396630
    Abstract: Adjuvant particles are prepared from lipoid-soluble substances, and compositions comprising the particles and biologically active substances adsorbed thereon are provided. The adjuvant systems are capable of binding a wide variety of biologically active substances, and can be used in vivo and in vitro as well.
    Type: Grant
    Filed: December 19, 1980
    Date of Patent: August 2, 1983
    Assignee: Human Oltoanyagtermelo es Kutato Intezet
    Inventors: Zoltan Riedl, Laszlo Sztankov, Istvan Horvath
  • Water-soluble derivatives of 6,6'-methylene-bis-(2,2,4-trimethyl-1,2-dihydroquinoline)
    Patent number: 4356306
    Abstract: The invention relates to water-soluble alkali salts of mono- and disulfonic acid derivatives and mono- and disulfonamide derivatives of 6,6'-methylene-bis-(2,2,4-trimethyl-1,2-dihydroquinoline) and dimer and/or trimer condensation products thereof bound with a methylene bridge at the 8 or 8' position. The new compounds are radioprotective and radiosensibilizers at the same time, and may be used both in the therapy and prophylaxis of malignant tumors.
    Type: Grant
    Filed: July 2, 1980
    Date of Patent: October 26, 1982
    Assignees: Material Vegyipari Szovetkezet, Human Oltoanyagtermelo es Kutato Intezet
    Inventors: Vilmos Bar, Joszef Boszormenyi, Peter Richter, Jeno Mercz, Tamas Rozsnyai
  • Biological wound covering and method for producing same
    Patent number: 4347841
    Abstract: A biological dressing for open wounds, especially large-area burn wounds, is formed by removing free hemoglobin from a red blood cell concentrate which is subjected to hemolysis. The product thus contains the stroma, subcellular elements and precipitated protein from the human red blood corpuscle concentrate freed from the hemoglobin and can be used in a pulverulant or layer form with, if desired, an appropriate support.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: September 7, 1982
    Assignee: Human Oltoanyagtermelo es Kutato Intezet
    Inventors: Janos Benyo, Tibor Papp, Janos Tolnay