Abstract: Lupus erythematosus can be treated by administering therapeutic amounts of ?5-androstene-3?-ol-7,17-dione and metabolizable precursors thereof, such as ?5-androstene-3b-acetoxy-7,17-dione, which are readily metabolized in vivo to ?5-androstene-3?-ol-7,17-dione but are not appreciably metabolizable in vivo to androgens, estrogens or dehydroepiandrosterone. Such treatment can be prophylactic, ameliorative or curative in nature.