Patents Assigned to Huntington Medical Research Institutes
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Publication number: 20230381009Abstract: An intraoral stimulation device configured to be positioned in a mouth of a patient. The device includes a sensor and one or more electrodes. The sensor is configured to monitor a position of the tongue and/or force exerted by the tongue against the sensor and to transmit a signal encoding tongue information. The electrode(s) is/are configured to deliver electrical stimuli to the patient's hard palate when the tongue information indicates that the tongue has moved from a desired position to an undesired position in the mouth. The electrical stimuli causes the tongue to move from the undesired position to the desired position.Type: ApplicationFiled: April 17, 2023Publication date: November 30, 2023Applicant: Huntington Medical Research InstitutesInventor: Douglas B. McCreery
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Patent number: 11654045Abstract: An intraoral stimulation device configured to be positioned in a mouth of a patient. The device includes a sensor and one or more electrodes. The sensor is configured to monitor a position of the tongue and/or force exerted by the tongue against the sensor and to transmit a signal encoding tongue information. The electrode(s) is/are configured to deliver electrical stimuli to the patient's hard palate when the tongue information indicates that the tongue has moved from a desired position to an undesired position in the mouth. The electrical stimuli causes the tongue to move from the undesired position to the desired position.Type: GrantFiled: October 18, 2018Date of Patent: May 23, 2023Assignee: Huntington Medical Research InstitutesInventor: Douglas B. McCreery
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Publication number: 20220236294Abstract: Methods to determine risk of Alzheimer's disease and applications thereof are described. Generally, systems and methods utilize analyte measurements, such as dicarboxylic acid levels, to determine a risk of Alzheimer's disease. Based on Alzheimer disease risk, diagnostics or treatments can be performed.Type: ApplicationFiled: June 11, 2020Publication date: July 28, 2022Applicant: Huntington Medical Research InstitutesInventors: Alfred N. Fonteh, Michael G. Harrington, Katherine Jane Hamblin
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Publication number: 20220096515Abstract: Methods of treatment and pharmaceutical formulations configured to prevent psychiatric diseases and/or disorders in offspring are provided. The methods and treatments use a regulator of angiogenesis pathways. The regulator can restore GABA secretion and neuronal migration. The regulator may be administered during pregnancy of an individual, thus allowing proper development of a fetal brain.Type: ApplicationFiled: September 28, 2021Publication date: March 31, 2022Applicant: Huntington Medical Research InstitutesInventor: Anju Vasudevan
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Patent number: 11229383Abstract: A device is described for interrogating human skin using tight coupling between the transmitter and receiver of the millimeter waves (MMWs). Methods are provided to evaluate changes in the amplitude and/or phase of the transmitted MMWs in order to estimate the blood concentration of glucose. Using this device and the related methods, the blood glucose concentration or a change in the blood glucose concentration can be monitored for diagnosing diabetes mellitus and other metabolic disorders of carbohydrate metabolism characterized by either high blood glucose level (hyperglycemia) or low blood glucose level (hypoglycemia), as well as for monitoring (including self-monitoring) a metabolic disorder progression or an efficacy of treatment.Type: GrantFiled: August 25, 2015Date of Patent: January 25, 2022Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Victor Pikov, Peter H. Siegel
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Patent number: 11045644Abstract: A new class of peripheral nerve interfaces that combines microfluidics with microelectronics. A peripheral nerve interface that allows intraneural targeting through the combined use and sequential application of lysing agents and neurotrophic factors.Type: GrantFiled: August 12, 2016Date of Patent: June 29, 2021Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Ellis Meng, Victor Pikov
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Patent number: 10124076Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.Type: GrantFiled: February 27, 2013Date of Patent: November 13, 2018Assignee: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Brian D. Ross, Pratip Bhattacharya
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Publication number: 20180043155Abstract: The present invention relates to medical devices and, more particularly, to medical devices that deliver neuromodulating therapy.Type: ApplicationFiled: February 19, 2016Publication date: February 15, 2018Applicants: GALVANI BIOELECTRONICS LIMITED, HUNTINGTON MEDICAL RESEARCH INSTITUTES, UNIVERSITY OF CHILIInventors: Hans Jakob Kristoffer FAMM, Hernan E. LARA, Victor Eugene PIKOV, Arun SRIDHAR
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Patent number: 9207296Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.Type: GrantFiled: May 20, 2014Date of Patent: December 8, 2015Assignee: Huntington Medical Research InstitutesInventors: Pratip Bhattacharya, Brian D. Ross
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Publication number: 20150022204Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.Type: ApplicationFiled: May 20, 2014Publication date: January 22, 2015Applicant: Huntington Medical Research InstitutesInventors: Pratip BHATTACHARYA, Brian D. ROSS
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Publication number: 20140323839Abstract: The present invention describes an apparatus, a systems and a method for the treatment of obstructive sleep apnea. the treatment involves monitoring the position of the tongue and/or the force exerted by the tongue an electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.Type: ApplicationFiled: May 20, 2014Publication date: October 30, 2014Applicant: Huntington Medical Research InstitutesInventor: Douglas B. McCreery
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Publication number: 20140308753Abstract: Provided herein are methods of diagnosing Alzheimer's disease (“AD”) based on characteristic changes of the levels of certain free amino acids or dipeptides (collectively termed as “AD diagnosis markers”) in the body fluid sample of an individual, carnosine synthesis activities in the plasma, and dopamine synthesis activities in the plasma. Also provided are methods of simultaneously determining the levels of at least two free amino acids or dipeptides in the biological fluid sample of an individual.Type: ApplicationFiled: January 13, 2014Publication date: October 16, 2014Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Alfred N. FONTEH, Michael G. HARRINGTON
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Patent number: 8831739Abstract: The invention relates to a multielectrode probe having a silicon substrate which supports multiple conductive electrodes for deep-brain electrical stimulation or recording of neural responses. The substrate has an upper end with multiple conductive portions for bonding to lead wires, and an elongated shank extends from the upper end. The shank supports multiple spaced-apart electrodes, typically ten in number, and conductive traces electrically connect the electrodes and conductive traces. Multiple probes are combined, and supported as an array by a cylindrical alignment cylinder.Type: GrantFiled: June 2, 2006Date of Patent: September 9, 2014Assignee: Huntington Medical Research InstitutesInventors: Douglas B. McCreery, Martin Han
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Patent number: 8774943Abstract: The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.Type: GrantFiled: December 18, 2012Date of Patent: July 8, 2014Assignee: Huntington Medical Research InstitutesInventor: Douglas B. McCreery
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Patent number: 8766633Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.Type: GrantFiled: October 14, 2010Date of Patent: July 1, 2014Assignee: Huntington Medical Research InstitutesInventors: Pratip Bhattacharya, Brian D. Ross
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Patent number: 8670941Abstract: Provided herein are methods of diagnosing Alzheimer's disease (“AD”) based on characteristic changes of the levels of certain free amino acids or dipeptides (collectively termed as “AD diagnosis markers”) in the body fluid sample of an individual, carnosine synthesis activities in the plasma, and dopamine synthesis activities in the plasma. Also provided are methods of simultaneously determining the levels of at least two free amino acids or dipeptides in the biological fluid sample of an individual.Type: GrantFiled: August 17, 2007Date of Patent: March 11, 2014Assignee: Huntington Medical Research InstitutesInventors: Alfred N. Fonteh, Michael G. Harrington
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Publication number: 20140065073Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.Type: ApplicationFiled: February 27, 2013Publication date: March 6, 2014Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventor: HUNTINGTON MEDICAL RESEARCH INSTITUTES
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Publication number: 20130317349Abstract: The present invention relates to compositions and methods useful in connection with magnetic resonance imaging. In various embodiments, the invention employs the PASADENA polarization technique to prepare contrast agents that target complementary molecules in the body and/or that are processed through predetermined, natural metabolic pathways. The invention includes methods of using the contrast agents and kits including the same. In one embodiment, a diagnostic and prognostic method relating to Alzheimer's disease is described. Further embodiments relate to medical devices including the contrast agents.Type: ApplicationFiled: February 21, 2013Publication date: November 28, 2013Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventor: HUNTINGTON MEDICAL RESEARCH INSTITUTES
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Publication number: 20130190606Abstract: Using both quantitative MRI and quantitative MRS, the inventor demonstrates herein that as age and dementia progress, hippocampal volume (HV), amygdala volume (AV), and NAA/mI ratio all decrease compared to normal controls. The inventor's data also demonstrate herein that NAA/mI vs. total amygdala volume showed a very strong linear correlation, while NAA/mI vs. mean total hippocampal volume had a lesser but still significant correlation. Further, after analyzing the data derived from both quantitative MRI and quantitative MRS methods, the inventor made the surprising discovery that the two tests, when combined, provide significantly improved biomarkers over either alone, and are more effective at early MCI and/or AD diagnosis, as well as HS diagnosis.Type: ApplicationFiled: January 25, 2013Publication date: July 25, 2013Applicant: Huntington Medical Research InstitutesInventor: Huntington Medical Research Institutes
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Publication number: 20130190836Abstract: The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.Type: ApplicationFiled: December 18, 2012Publication date: July 25, 2013Applicant: Huntington Medical Research InstitutesInventor: Douglas B. McCreery