Abstract: Guide for a sliding glazing, in particular for an automobile, the guide being intended to be fastened onto a glazing and to cooperate with a glass run seal, the guide comprising a body made of a single piece and having an elongated shape along an axis (A), the body comprising: a fastening portion extending along the axis (A) and having a face configured to be fastened onto the glazing, and a guide portion extending along said axis (A) and being cross sectional L-shaped, the guide portion comprising a wall substantially parallel to the face and a free rib substantially perpendicular to the face, the free rib including at least one non-planar lateral face.

Abstract: The invention relates to a pipe for conveying a fluid, in particular a coolant, for a vehicle, the pipe having a multi-layer structure and comprising: an inner layer defining an inner passage for fluid circulation, the inner layer being formed of a first material comprising an elastomer selected from the ethylene-propylene copolymers, an outer layer formed of a second material comprising: an elastomer selected from ethylene-vinyl acetate copolymers in a proportion of at least 50 phr, and a flame retardant according to a proportion of at least 50 phr, and an intermediate bonding layer arranged between the inner layer and the outer layer and comprising a mixture of an ethylene-propylene copolymer with an ethylene-vinyl acetate copolymer or a polyacrylate or an ethylene acrylate copolymer.

Abstract: The present disclosure provides compositions and uses thereof for treating a disease or disorder associated with CD20 expression. Treatments of this disclosure include use of a host cell expressing a fusion protein, such as an anti-CD20 CAR, optionally in combination with a CD20-specific binding molecule, a chemotherapeutic, an inhibitor of an immunosuppression component, or combinations thereof.

Abstract: Stem cells are modified to express an extracellular component including a tag cassette. The tag cassette can be used to detect, enrich, isolate, activate, track, deplete, or eliminate modified cells. The cells can be administered before or following differentiation into a more committed cell type.

Abstract: The invention relates to a thermoplastic polymer composition comprising polyamides, its preparation method and a device for a motor vehicle capable of damping vibrations. The composition (I1, I2, I3, I4) comprises an aliphatic polyamide a polyphthalamide coming from a C6-C12 aliphatic diamine and from an aromatic diacid comprising terephthalic acid, the aliphatic polyamide/polyphthalamide weight ratio being >1 and a reinforcing filler comprising glass fibers. The composition has, after “RH50” conditioning, maximum tan delta values according to ISO 6721-5 between 60-90° C. and 1-3000 Hz, with (i) tan delta >4.20% at 60° C. and/or (ii) tan delta >4.00% at 80° C. and/or (iii) tan delta >3.80% at 90° C.

Abstract: Methods to create barcoded influenza viruses without disrupting the function of the viral proteins and the proper packaging of the viral genome segments are described. The barcoded influenza viruses can be used within deep mutational scanning libraries to map influenza resistance mutations to therapeutic treatments. The libraries can also be used to predict influenza strains that may become resistant to therapeutic treatments and/or more easily evolve to infect new species. The libraries include features that allow efficient collection and assessment of informative data, obviating bottlenecks of previous approaches.

Abstract: SMA actuators and related methods are described. One embodiment of an actuator includes a base; a plurality of buckle arms; and at least a first shape memory alloy wire coupled with a pair of buckle arms of the plurality of buckle arms. Another embodiment of an actuator includes a base and at least one bimorph actuator including a shape memory alloy material. The bimorph actuator attached to the base.

Abstract: The invention relates to a cathode composition usable in a lithium-ion battery, to a process for the preparation of this composition, to such a cathode and to a lithium-ion battery incorporating this cathode. The composition comprises an active material which comprises an alloy of lithium nickel cobalt aluminum oxides, an electrically conductive filler and a polymeric binder, and it is such that said polymeric binder comprises at least one modified polymer (Id2) which is the product of a thermal oxidation reaction of a starting polymer and which incorporates oxygenated groups comprising CO groups, the composition being capable of being obtained by the molten route and without evaporation of solvent by being the product of said thermal oxidation reaction applied to a precursor mixture comprising said active material, said electrically conductive filler, said starting polymer and a sacrificial polymer phase.

Abstract: Provided are methods, kits and compositions related to toxicity associated with administration of cell therapy for the treatment of diseases or conditions, e.g., cancer, including methods for use in predicting and treating a toxicity. In some embodiments, the toxicity is a neurotoxicity or cytokine release syndrome (CRS), such as a severe neurotoxicity or a severe CRS. The methods generally involve detecting a parameter of a biomarker or individually a parameter of each biomarker in a panel of biomarkers, such as a concentration, amount or activity, and comparing the detected parameter to a reference value for the parameter to determine if the subject is at risk for developing the toxicity, such as neurotoxicity or CRS or severe neurotoxicity or severe CRS.

Abstract: The invention relates to a temperature sensor (10) for a fluid pipe, in particular for a motor vehicle, this sensor (10) comprising a first part (20) comprising a flat surface (22) configured to be in contact with a fluid and on which is located a track (41) forming a thermosensitive element (40), this track (41) having a generally elongated shape and comprising opposite ends (41A, 41B) connected respectively to terminals (43) of the sensor (10) by electrical conductors (42) embedded in said body (15). The invention also relates to a fluid pipe comprising such a sensor (10), a motor vehicle comprising such a sensor (10) or such a pipe and a method for manufacturing such a sensor (10).

Abstract: Here are described composite panels comprising at least one integrated or embedded electrical circuit, their methods of manufacturing and their use in the aeronautic and aircraft industries. Also described are aircraft components including the composite panel as defined herein.

Abstract: Nanoparticle systems that genetically modify monocytes/macrophages in vivo to (1) recruit additional immune cells to a treatment site; (2) remain activated at the treatment site providing an on-going stimulatory signal to other immune cells; and (3) secrete bispecific immune-cell engaging antibodies that bind antigens on cells of interest at the treatment site and also bind and activate the recruited immune cells to destroy the bound cell. The systems can also inhibit the activity of transforming growth factor beta (TGF?).

Abstract: Electric tabs and methods for manufacturing are described. A method includes disposing a dielectric layer on a second side of a base material, the base material having a first side and the second side. The method including developing the dielectric layer on the second side of the base material. And, the method including etching the first side of the base material to form an electrode tab.

Abstract: The invention proposes a method for manufacturing a grille for a cascade type thrust reverser, of a jet engine, said method including the following steps: a) manufacturing a first component comprising continuous or long fibres, pre-impregnated by a thermoplastic or thermosetting resin; b) manufacturing, subsequently or together with step a), a series of second components each including discontinuous fibres, pre-impregnated by a thermoplastic or thermosetting resin, step b) being carried out such that the second components are, on the one hand, arranged transversally with respect to a longitudinal direction of the first component on at least one side of the first component and, on the other hand, spaced from one another according to this longitudinal direction, so as to form a comb-shaped structure, wherein the second components are consolidated to the first component.

Abstract: The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.

Abstract: A pressure sensor (10) for a fluid circuit, in particular, of a motor vehicle, the sensor comprising a body (12) comprising a fluid inlet (14), a fluid outlet (16) and an internal chamber (18) for connecting the inlet to the fluid outlet for the fluid flow in said body, the sensor further comprising an elastically deformable membrane (20) located in said chamber and comprising a first face (20a) intended to be in contact with the fluid flowing in the body, wherein the sensor further comprises a resonant circuit (22) of the RLC type located in said chamber and associated with a readout circuit (23) located outside the chamber (18).

Abstract: A pressure damping device for a fluid circuit includes a lower body having a fluid inlet port and a fluid outlet port. An upper cover attaches to the body. An elastically deformable membrane is interposed between the body and the cover, and a circular cup is arranged on the membrane. A spring is interposed between the cup and a bottom of the cover. The body includes a support member for supporting the membrane, with the support member projecting from the first bottom and including a free upper end on which the membrane is adapted to be supported.

Abstract: Embodiments of the disclosure include a suspension assembly having a support member, a moving member movably coupled to the support member, and shape metal alloy wires coupled between the support and moving members by attachment structures. In embodiments, the attachment structures include a first portion and a second portion configured to be crimped together. In embodiments, at least one of the first and second portions include an etched recess.

Abstract: The current disclosure provides recombinant adenoviral vectors and adenoviral genomes that can accommodate or that contain a large transposon payload, for instance a transposon payload of up to 40 kb. The adenoviral vectors and genomes can deliver the large transposon payload into a target genome, for instance for gene therapy.

Abstract: Systems and methods to increase the efficacy of vaccines that require or are rendered more effective with T cell mediated immunity are described. The systems and methods utilize polynucleotides that genetically modify T cells to express a T cell receptor specific for an administered vaccine antigen.