Patents Assigned to ICOS
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Patent number: 11802874Abstract: The present invention corresponds to the field of cancer and is related to predicting cancer detection, diagnosis, monitoring and prediction of response to treatment, in particular platelet derived-endothelial cell growth factor (PD-ECGF) levels for their use as a potential value in monitoring disease evolution and predicting response to anti-angiogenic treatment.Type: GrantFiled: March 10, 2016Date of Patent: October 31, 2023Assignees: FUNDACIO INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL), INSTITUT CATALÀ D'ONCOLOGIA (ICO)Inventors: Oriol Casanovas Casanovas, Gabriela Jiménez Valerio, María Ochoa De Olza, Valentí Navarro Pérez, Nicklas Bassani, Helena Verdaguer
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Patent number: 11578104Abstract: The invention relates to a recombinant adenovirus comprising an albumin-binding moiety on the outer surface of the adenoviral hexon protein, pharmaceutical compositions containing it and its medical use. Particularly, the invention relates to an oncolytic adenovirus comprising a sequence encoding an albumin-binding moiety inserted in the hypervariable region 1 (HVR1) of the hexon protein coding sequence and its use in the prevention and/or treatment of cancer.Type: GrantFiled: February 19, 2020Date of Patent: February 14, 2023Assignees: Fundació Institut D'lnvestigació Biomedica De Bellvitge (í DIBELL), INSTITUT CATALA D'ONCOLOGIA (ICO)Inventors: Ramon Alemany Bonastre, Luis Alfonso Rojas Expósito
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Patent number: 11541433Abstract: Containing device for a treatment machine for loose products, provided internally with a treatment compartment that has at least an open side for loading the loose products to be treated, and for unloading the loose products that have been treated; the containing device comprises at least a first loading door for the loose products to be treated, positioned on a first portion of said open side and associated with at least a respective opening and closing unit, and at least a second unloading door for the loose products that have been treated, positioned on a second portion of said open side and associated with at least a respective opening and closing unit.Type: GrantFiled: March 14, 2017Date of Patent: January 3, 2023Assignee: ICOS PHARMA S.P.A.Inventors: Ivone Capovilla, Ottorino Casonato, Fabio Zardini
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Patent number: 10906907Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of preparing such compounds are also disclosed, including the preparation and use of the compound tert-butyl (S)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate of formula (110) as a precursor to synthesize an exemplary compound disclosed in this application, (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.Type: GrantFiled: May 21, 2019Date of Patent: February 2, 2021Assignee: ICOS CORPORATIONInventors: Edward A. Kesicki, Kerry W. Fowler, Danwen Huang, Hua Chee Ooi, Amy Oliver, Kamal Deep Puri, Fuqiang Ruan, Jennifer A. Treiberg
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Patent number: 10695349Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.Type: GrantFiled: August 1, 2019Date of Patent: June 30, 2020Assignee: ICOS CorporationInventors: Chanchal Sadhu, Ken Dick, Jennifer Treiberg, C. Gregory Sowell, Edward A. Kesicki, Amy Oliver
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Patent number: 10604549Abstract: The invention relates to a recombinant adenovirus comprising an albumin-binding moiety on the outer surface of the adenoviral hexon protein, pharmaceutical compositions containing it and its medical use. Particularly, the invention relates to an oncolytic adenovirus comprising a sequence encoding an albumin-binding moiety inserted in the hypervariable region 1 (HVR1) of the hexon protein coding sequence and its use in the prevention and/or treatment of cancer.Type: GrantFiled: April 30, 2015Date of Patent: March 31, 2020Assignees: FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL), INSTITUT CATALÀ D'ONCOLOGIA (ICO)Inventors: Ramon Alemany Bonastre, Luis Alfonso Rojas Expósito
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Patent number: 10398695Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.Type: GrantFiled: May 30, 2018Date of Patent: September 3, 2019Assignee: ICOS CORPORATIONInventors: Chanchal Sadhu, Ken Dick, Jennifer Treiberg, C. Gregory Sowell, Edward A. Kesicki, Amy Oliver
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Patent number: 10336756Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of preparing such compounds are also disclosed, including the use of (S)-2-(1-aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one as a precursor to synthesize an exemplary compound disclosed in this application, (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.Type: GrantFiled: August 13, 2015Date of Patent: July 2, 2019Assignee: ICOS CORPORATIONInventors: Edward A. Kesicki, Kerry W. Fowler, Danwen Huang, Hua Chee Ooi, Amy Oliver, Kamal Deep Puri, Fuqiang Ruan, Jennifer Treiberg
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Patent number: 10286096Abstract: Device for discharging loose products includes a conveyor body attachable with its first end to a treatment machine for the loose products. The conveyor body, in correspondence to its second end, comprises a wall in which a collection aperture is made, selectively openable/closable by means of an opening/closing member to allow the discharge of said loose products. The discharge device for loose products further includes a pneumatic deliverer located in the conveyor body and configured to deliver a stream of gas at least toward the wall and determine the discharge, through the collection aperture, at least of the loose products that are deposited on the wall.Type: GrantFiled: September 24, 2015Date of Patent: May 14, 2019Assignee: ICOS PHARMA S.P.A.Inventor: Ottorino Casonato
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Patent number: 10066231Abstract: Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell.Type: GrantFiled: November 25, 2015Date of Patent: September 4, 2018Assignee: CMC ICOS BIOLOGICS, INC.Inventor: Howard Robert Grahame Clarke
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Patent number: 10010550Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.Type: GrantFiled: May 8, 2017Date of Patent: July 3, 2018Assignee: ICOS CorporationInventors: Chanchal Sadhu, Ken Dick, Jennifer Treiberg, C. Gregory Sowell, Edward A. Kesicki, Amy Oliver
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Patent number: 9957525Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.Type: GrantFiled: March 7, 2016Date of Patent: May 1, 2018Assignee: CMC ICOS BIOLOGICS, INC.Inventor: Howard R. Clarke
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Patent number: 9943405Abstract: Advances in filling apparatus, handheld tools, surgical techniques and intraoperative biometry for implanting and adjusting an accommodative liquid lens are disclosed. The lens may be attached to or retained within a handheld surgical tool, which can be fluidly connectable to a filling console to fill the lens with a liquid. In various embodiments, a filling console facilitates aspirating liquid out of the lens in order to ensure the absence of residual bubbles and filling of the lens with fluid during surgery, as well as during post-operative adjustments to the lens. Actuated by the surgeon, the filling console can aspirate fluid from the lens and inject fluid into the lens following insertion thereof.Type: GrantFiled: May 16, 2012Date of Patent: April 17, 2018Assignee: ICO, INC.Inventors: Sean Caffey, Charles DeBoer, Mark Humayun, Yu-Chong Tai
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Publication number: 20180052164Abstract: The present invention corresponds to the field of cancer and is related to predicting cancer detection, diagnosis, monitoring and prediction of response to treatment, in particular platelet derived-endothelial cell growth factor (PD-ECGF) levels for their use as a potential value in monitoring disease evolution and predicting response to anti-angiogenic treatment.Type: ApplicationFiled: March 10, 2016Publication date: February 22, 2018Applicants: FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL), INSTITUT CATALÀ D'ONCOLOGIA (ICO)Inventors: Oriol CASANOVAS CASANOVAS, Gabriela JIMÉNEZ VALERIO, María OCHOA DE OLZA, Valentí NAVARRO PÉREZ, Nicklas BASSANI, Helena VERDAGUER
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Patent number: 9814569Abstract: In various embodiments, implants including reservoirs, such as intraocular lenses, feature flexible membranes and valves integrated therewith, the valves having apertures that are normally closed.Type: GrantFiled: December 28, 2015Date of Patent: November 14, 2017Assignee: ICO, INC.Inventors: Wendian Shi, Charles DeBoer, Sean Caffey, Mark S. Humayun, Yu-Chong Tai
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Publication number: 20170290939Abstract: Device for discharging loose products includes a conveyor body attachable with its first end to a treatment machine for the loose products. The conveyor body, in correspondence to its second end, comprises a wall in which a collection aperture is made, selectively openable/closable by means of an opening/closing member to allow the discharge of said loose products. The discharge device for loose products further includes a pneumatic deliverer located in the conveyor body and configured to deliver a stream of gas at least toward the wall and determine the discharge, through the collection aperture, at least of the loose products that are deposited on the wall.Type: ApplicationFiled: September 24, 2015Publication date: October 12, 2017Applicant: ICOS PHARMA S.P.A.Inventor: Ottorino CASONATO
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Publication number: 20170260677Abstract: Containing device for a treatment machine for loose products, provided internally with a treatment compartment that has at least an open side for loading the loose products to be treated, and for unloading the loose products that have been treated; the containing device comprises at least a first loading door for the loose products to be treated, positioned on a first portion of said open side and associated with at least a respective opening and closing unit, and at least a second unloading door for the loose products that have been treated, positioned on a second portion of said open side and associated with at least a respective opening and closing unit.Type: ApplicationFiled: March 14, 2017Publication date: September 14, 2017Applicant: ICOS PHARMA S.P.A.Inventors: Ivone Capovilla, Ottorino Casonato, Fabio Zardini
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Patent number: 9487772Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.Type: GrantFiled: November 27, 2013Date of Patent: November 8, 2016Assignee: ICOS CORPORATIONInventors: Chanchal Sadhu, Ken Dick, Jennifer Treiberg, C. Gregory Sowell, Edward A. Kesicki, Amy Oliver
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Patent number: 9297024Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.Type: GrantFiled: March 11, 2014Date of Patent: March 29, 2016Assignee: CMC ICOS BIOLOGICS, INC.Inventor: Howard R. Clarke
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Patent number: 9212367Abstract: Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell.Type: GrantFiled: August 6, 2010Date of Patent: December 15, 2015Assignee: CMC ICOS BIOLOGICS, INC.Inventor: Howard R. Clarke