Patents Assigned to IGEA S.r.l.
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Patent number: 7625729Abstract: Electro-poration device for the permeabilization of cells contained in a substrate comprising a signal generator for generating a stimulating signal applied by means of electrodes to the substrate wherein an electric field permeabilizing the cells membranes is induced. The device calculates and monitors the instantaneous value or the ratio GT between the current flowing through the substrate and the voltage of the stimulating signal applied to the substrate; in particular, the stimulating signal is applied in a modified manner according to the shape of an initial portion of the waveform of a curve CGT representing the value of ratio GT in successive instants after the application of the stimulating signal. The system will achieve permeabilization of cells in substrate with no or minimum damage, allowing to introduce or to extract molecules in or from the electropermeabilized living cells.Type: GrantFiled: June 10, 2003Date of Patent: December 1, 2009Assignee: IGEA S.r.l.Inventors: Damijan Miklavcic, Lluis Mir
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Patent number: 7566295Abstract: Electromagnetic field stimulator device in which a current generator device supplies a solenoid with current the waveform of which includes the repetition of a ramp having a certain slope. This current causes the generation of an electromagnetic field that induces on a control probe irradiated by the electromagnetic field, an induced voltage of markedly constant amplitude during the ramp-like linear growth period of the current. This electromagnetic field is used to preserve the integrity of articular cartilage subject to degeneration.Type: GrantFiled: November 10, 2004Date of Patent: July 28, 2009Assignee: IGEA S.R.L.Inventors: Roberto Giardino, Ruggero Cadossi, Stefania Setti
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Patent number: 7306940Abstract: An electroporation device having a signal generating circuit (3) connectable at the output to electrodes (5) fittable to a substrate (35) having cells. The electrodes (5) produce an electric field which induces permeabilization of the cell membranes to facilitate introduction of substances into the cells. The amplitude of the signal (12) applied to the electrodes is closed-loop controlled on the basis of the impedance (Z(?)) of the substrate, so as to regulate the amplitude of the signal following a reduction in impedance caused by permeabilization of the cell membranes.Type: GrantFiled: October 21, 2002Date of Patent: December 11, 2007Assignee: IGEA S.r.l.Inventors: Damijan Miklavcic, Lluis Mir, Eberhard Neumann, Bertil Persson
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Patent number: 7004903Abstract: An electronic system for determining the density and structure of bone tissue and stimulating osteogenesis in dentistry, having a diagnosis system for injecting an ultrasonic signal U(t) into a bone portion and analyzing the ultrasonic signal received after traveling through the bone portion to determine a number of characteristic data items of the signal describing physical and structural characteristics of the bone tissue. The diagnosis system performs a number of measuring steps to determine and memorize a set of characteristic data items describing progress of a bone growth process and/or a bone repair process following extraction of a tooth and/or placement of a dental prosthesis in the bone portion. The system also has an osteogenesis stimulation system for directing an ultrasonic stimulation signal onto the bone portion to promote the bone growth and/or bone repair process.Type: GrantFiled: December 4, 2002Date of Patent: February 28, 2006Assignee: IGEA S.r.l.Inventors: Ruggero Cadossi, Stefania Setti, Claudio Bertacchini
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Patent number: 6436042Abstract: An ultrasonic measuring device and method for determining bone density and structure includes an electronic control unit, a positioning unit housing at least a transducer pair and carrying a receiving unit, the unit being adapted to be coupled to a bone segment of the human body and carrying a locating device for ascertaining the position of the bone segment with respect to the unit, and an electronic unit for determining a first waveform representing an ultrasonic signal transmitted through the metaphysis portion of the bony segment and a second waveform representing an ultrasonic signal transmitted through the diaphysis portion, and an electronic processor and display for displaying the first and second waveforms as a measured output.Type: GrantFiled: April 24, 1998Date of Patent: August 20, 2002Assignee: IGEA S.r.l.Inventors: Ruggero Cadossi, Stefano Battista, Alessandro Corsi, Antonio Dorati, Claus-C. Glüer, Reinhard Barkmann
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Patent number: 5564423Abstract: Electronic system for measuring the density and structure of bone, in which an electronic central unit is equipped with ultrasonic calipers designed to be applied to a segment of the human body (for example, a finger) containing bone tissue to be examined. The central unit is designed to display on a screen an image of the ultrasonic signal transmitted through the bone tissue and highlight, on that image, two vertical marker lines correlated with the velocity with which the ultrasound signals are transmitted through the bone tissue and the velocity of transmission of the ultrasound signals through soft tissue. These vertical marker lines mark off the portion of the image that represents the ultrasonic signal received after passing through the bone tissue. The amplitude of this signal depends on the absorption of the ultrasound when passing through the bone tissue.Type: GrantFiled: January 11, 1995Date of Patent: October 15, 1996Assignee: IGEA S.r.l.Inventors: Ruggero Mele, Riccardo Isani, Ruggero Cadossi
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Patent number: 5276429Abstract: A portable generator generates a predetermined signal and has an output connected to a first transducer for transmitting the above signal to the body of a first operator (e.g. physician, nurse, etc.); and processing means for analyzing a signal picked up by a second transducer on a second operator (e.g. a patient, etc.) and detecting the significant presence of the above predetermined signal, as a consequence, for example, of direct or indirect contact between the first operator and the second operator.Type: GrantFiled: February 3, 1992Date of Patent: January 4, 1994Assignee: Igea S.r.l.Inventors: Ruggero Cadossi, Donata Marazzi
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Patent number: 5276428Abstract: A portable generator generates a predetermined signal and has an output connected to a first transducer for transmitting the above signal to the body of a first operator (e.g. physician, nurse, etc.); and processing means for analyzing a signal picked up by a second transducer on a second operator (e.g. a patient, etc.) and detecting the significant presence of the above predetermined signal, as a consequence, for example, of direct or indirect contact between the first operator and the second operator.Type: GrantFiled: February 3, 1992Date of Patent: January 4, 1994Assignee: IGEA S.r.l.Inventors: Ruggero Cadossi, Donata Marazzi