Patents Assigned to Imago
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Publication number: 20240104701Abstract: A method for visualizing luminance variance for an object may include receiving image data associated with a digital image of the object. An algorithm is applied to the image data to generate an enhanced image. The enhanced image includes connected pixel value lines representative of pixel value ranges from the input image to enable visualization of luminance variance of the object by the human eye.Type: ApplicationFiled: September 18, 2023Publication date: March 28, 2024Applicant: Imago Systems, Inc.,Inventors: Gene Ramsay, Thomas E. Ramsay, Karen Morgan, Oleksandr Andrushchenko, Anna Yang, Jermaine Headley, Victor Krivorotov, Gennadiy Lyashenko
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Patent number: 11932629Abstract: The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1A for the treatment or prevention of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.Type: GrantFiled: December 15, 2022Date of Patent: March 19, 2024Assignee: Imago Biosciences, Inc.Inventors: Amy E. Tapper, Cassandra Celatka, Michael Clare, Hugh Y. Rienhoff, Jr.
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Patent number: 11935215Abstract: A method of visualization, characterization, and detection of objects within an image by applying a local micro-contrast convergence algorithm to a first image to produce a second image that is different from the first image, wherein all like objects converge into similar patterns or colors in the second image.Type: GrantFiled: August 7, 2018Date of Patent: March 19, 2024Assignee: Imago Systems, Inc.Inventors: Thomas E. Ramsay, Eugene B. Ramsay
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Patent number: 11773068Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.Type: GrantFiled: September 22, 2021Date of Patent: October 3, 2023Assignee: Imago Biosciences, Inc.Inventors: Hugh Y. Rienhoff, Jr., John M. McCall, Michael Clare, Cassandra Celatka, Amy E. Tapper
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Patent number: 11734911Abstract: A method of visualization, characterization, and detection of objects within an image by applying a local micro-contrast convergence algorithm to a first image to produce a second image that is different from the first image, wherein all like objects converge into similar patterns or colors in the second image.Type: GrantFiled: December 21, 2020Date of Patent: August 22, 2023Assignee: Imago Systems, Inc.Inventors: Thomas E. Ramsay, Eugene B. Ramsay
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Patent number: 11655226Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.Type: GrantFiled: December 1, 2020Date of Patent: May 23, 2023Assignee: Imago Biosciences, Inc.Inventors: John M. McCall, Hugh Y. Rienhoff, Jr., Michael Clare
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Patent number: 11578059Abstract: The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1A for the treatment or prevention of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.Type: GrantFiled: May 13, 2019Date of Patent: February 14, 2023Assignee: Imago Biosciences. Inc.Inventors: Amy E. Tapper, Cassandra Celatka, Michael Clare, Hugh Y. Rienhoff, Jr.
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Patent number: 11390590Abstract: Provided in this disclosure are methods for the synthesis of substituted 2-arylcyclopropylamines and 2-heteroarylcyclopropylamines and related compounds. Also provided are methods for reduction of thioesters to aldehydes, and methods for reductive animation of cyclopropylamines.Type: GrantFiled: August 16, 2017Date of Patent: July 19, 2022Assignee: Imago Biosciences, Inc.Inventors: Amy E. Tapper, Cassandra Celatka, Arthur Glenn Romero, John M. McCall, Toni Chancellor, Jian-Xie Chen, Xuemei Chen, He Zhao, Betina Biolatto, Elisabeth C. A. Brot, Zhihua Li, Xiaoming Liao
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Publication number: 20220081427Abstract: The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.Type: ApplicationFiled: November 11, 2021Publication date: March 17, 2022Applicant: IMAGO PHARMACEUTICALS, INC.Inventors: Hing L. SHAM, Roy K. HOM, Andrei W. KONRADI, Gary D. PROBST, Simeon BOWERS, Anh TRUONG, R. Jeffrey NEITZ, Jennifer SEALY, Gergely TOTH
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Patent number: 11230534Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.Type: GrantFiled: November 1, 2019Date of Patent: January 25, 2022Assignee: Imago Biosciences, Inc.Inventors: Hugh Y. Rienhoff, Jr., John M. McCall, Michael Clare, Cassandra Celatka, Amy E. Tapper
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Patent number: 10882835Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.Type: GrantFiled: June 19, 2019Date of Patent: January 5, 2021Assignee: Imago Biosciences, Inc.Inventors: John M. McCall, Hugh Y. Rienhoff, Jr., Michael Clare
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Patent number: 10873681Abstract: A method of visualization, characterization, and detection of objects within an image by applying a local micro-contrast convergence algorithm to a first image to produce a second image that is different from the first image, wherein all like objects converge into similar patterns or colors in the second image.Type: GrantFiled: February 8, 2017Date of Patent: December 22, 2020Assignee: Imago Systems, Inc.Inventors: Thomas E. Ramsay, Eugene B. Ramsay
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Patent number: 10766954Abstract: The invention provides therapeutic antibodies and methods for treatment of diseases associated with diseases associated with aggregation of ?-synuclein, e.g., in the brain of a subject. Such methods provide administration of therapeutic antibodies to elicit a beneficial immunogenic response against aggregation of ?-synuclein. The methods are particularly useful for prophylactic and therapeutic treatment of diseases associated with the formation of Lewy bodies, e.g., Parkinson's disease.Type: GrantFiled: April 5, 2017Date of Patent: September 8, 2020Assignee: Imago Pharmaceuticals, Inc.Inventors: Irene Griswold-Prenner, Karen Chen
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Publication number: 20200277285Abstract: The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.Type: ApplicationFiled: May 12, 2020Publication date: September 3, 2020Applicant: IMAGO PHARMACEUTICALS, INC.Inventors: Hing L. SHAM, Roy K. HOM, Andrei W. KONRADI, Gary D. PROBST, Simeon BOWERS, Anh TRUONG, R. Jeffrey NEITZ, Jennifer SEALY, Gergely TOTH
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Publication number: 20200039972Abstract: The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.Type: ApplicationFiled: October 15, 2019Publication date: February 6, 2020Applicant: IMAGO PHARMACEUTICALS, INC.Inventors: Hing L. SHAM, Roy K. HOM, Andrei W. KONRADI, Gary D. PROBST, Simeon BOWERS, Anh TRUONG, R. Jeffrey NEITZ, Jennifer SEALY, Gergely TOTH
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Patent number: 10519118Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.Type: GrantFiled: April 12, 2018Date of Patent: December 31, 2019Assignee: Imago Biosciences, Inc.Inventors: Hugh Y. Rienhoff, Jr., John M. McCall, Michael Clare, Cassandra Celatka, Amy E. Tapper
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Patent number: 10370346Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.Type: GrantFiled: August 2, 2017Date of Patent: August 6, 2019Assignee: Imago Biosciences, Inc.Inventors: John M. McCall, Hugh Y. Rienhoff, Jr., Michael Clare
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Publication number: 20190194176Abstract: The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.Type: ApplicationFiled: February 28, 2019Publication date: June 27, 2019Applicant: IMAGO PHARMACEUTICALS, INC.Inventors: Hing L. SHAM, Roy K. HOM, Andrei W. KONRADI, Gary D. PROBST, Simeon BOWERS, Anh TRUONG, R. Jeffrey NEITZ, Jennifer SEALY, Gergely TOTH
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Publication number: 20180319780Abstract: The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.Type: ApplicationFiled: July 19, 2018Publication date: November 8, 2018Applicant: IMAGO PHARMACEUTICALS, INC.Inventors: Hing L. SHAM, Roy K. HOM, Andrei W. KONRAD!, Gary D. PROBST, Simeon BOWERS, Anh TRUONG, R. Jeffrey NEITZ, Jennifer SEALY, Gergely TOTH
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Patent number: 9981922Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.Type: GrantFiled: February 12, 2016Date of Patent: May 29, 2018Assignee: Imago Biosciences, Inc.Inventors: Hugh Y. Rienhoff, Jr., John M. McCall, Michael Clare, Cassandra Celatka, Amy E. Tapper
