Patents Assigned to iMBP Holding, LLC
  • Apolipoprotein C3 (ApoCIII) antagonists and methods of their use to remove ApoCIII inhibition of lipoprotein lipase (LPL)
    Patent number: 9783600
    Abstract: Provided herein are methods of increasing lipoprotein lipase (LPL) activity, by inhibiting apolipoprotein C3 (ApoCIII), which removes the ApoCIII inhibition of LPL, and permits VLDL to be converted to LDL. Also provided are methods for treating or preventing a lipid metabolism disorder, such as type 2 diabetes by use of an ApoCIII antagonist. Also provided are screening methods to identify ApoCIII antagonists.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: October 10, 2017
    Assignee: iMBP Holding, LLC
    Inventors: Urban A. Kiernan, David A. Phillips, Eric E. Niederkofler