Patents Assigned to Immunex Corporation
  • DNA encoding a soluble fragment of TRAIL polypeptide
    Patent number: 7972812
    Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: July 5, 2011
    Assignee: Immunex Corporation
    Inventors: Steven R. Wiley, Raymond G. Goodwin
  • SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR TREATMENT OF MEDICAL DISORDERS
    Publication number: 20110142832
    Abstract: The invention pertains to methods and compositions for treating medical disorders characterized by elevated levels or abnormal expression of TNF? by administering a TNF? antagonist, such as recombinant TNFR:Fc.
    Type: Application
    Filed: February 4, 2011
    Publication date: June 16, 2011
    Applicant: Immunex Corporation
    Inventor: Barbara K. FINCK
  • Antibodies that bind human OX2 receptors
    Patent number: 7956163
    Abstract: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors or agonists thereof.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: June 7, 2011
    Assignee: Immunex Corporation
    Inventors: Anne-Reńee Van Der Vuurst De Vries, Laurent J. Galibert
  • Antibodies that bind B7L-1
    Patent number: 7939640
    Abstract: The invention is directed to B7L-1 as a purified and isolated protein, the DNA encoding the B7L-1, host cells transfected with cDNAs encoding B7L-1 and processes for preparing B7L-1 polypeptides.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: May 10, 2011
    Assignee: Immunex Corporation
    Inventor: Peter Robert Baum
  • Kits for detecting rank nucleic acids
    Patent number: 7932375
    Abstract: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: April 26, 2011
    Assignee: Immunex Corporation
    Inventor: Dirk M Anderson
  • ATTRACTIN/MAHOGANY-LIKE POLYPEPTIDES, POLYNUCLEOTIDES, ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20110091469
    Abstract: The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides or fragments, and assays and methods employing these polypeptides, antibodies, and polynucleotides.
    Type: Application
    Filed: December 22, 2010
    Publication date: April 21, 2011
    Applicant: Immunex Corporation
    Inventor: Dirk M. Anderson
  • METHOD OF INHIBITING OSTEOCLAST ACTIVITY
    Publication number: 20110086033
    Abstract: Methods for inhibiting osteoclastogenesis by administering a soluble RANK polypeptide are disclosed. Such methods can be used to treat a variety of different cancers, including bone cancer, multiple myeloma, melanoma, breast cancer, squamous cell carcinoma, lung cancer, prostate cancer, hematologic cancers, head and neck cancer and renal cancer.
    Type: Application
    Filed: August 4, 2010
    Publication date: April 14, 2011
    Applicant: IMMUNEX CORPORATION
    Inventors: Dirk M. ANDERSON, Laurent J. GALIBERT
  • Soluble tumor necrosis factor receptor treatment of medical disorders
    Patent number: 7915225
    Abstract: The invention pertains to methods and compositions for treating medical disorders characterized by elevated levels or abnormal expression of TNF? by administering a TNF? antagonist, such as recombinant TNFR:Fc.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: March 29, 2011
    Assignee: Immunex Corporation
    Inventor: Barbara K Finck
  • Attractin/mahogany-like polypeptides
    Patent number: 7893204
    Abstract: The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides or fragments, and assays and methods employing these polypeptides, antibodies, and polynucleotides.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: February 22, 2011
    Assignee: Immunex Corporation
    Inventor: Dirk M. Anderson
  • FAMILY OF IMMUNOREGULATORS DESIGNATED LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTORS (LIR)
    Publication number: 20110028687
    Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide probes having defined sequences, processes for producing polypeptides of the LIR family, and antagonistic antibodies to LIR family members. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
    Type: Application
    Filed: October 14, 2010
    Publication date: February 3, 2011
    Applicant: Immunex Corporation
    Inventor: David J. COSMAN
  • ACPL-RELATED ASSAYS
    Publication number: 20110027805
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Application
    Filed: October 12, 2010
    Publication date: February 3, 2011
    Applicant: IMMUNEX CORPORATION
    Inventors: John E. SIMS, Teresa L. BORN
  • LIR-9, a novel leukocyte immunoglobulin-like receptor
    Patent number: 7875703
    Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: January 25, 2011
    Assignee: Immunex Corporation
    Inventors: Dirk M. Anderson, Luis G. Borges
  • Nucleic acids encoding antibodies that bind interleukin-4 receptor
    Patent number: 7872113
    Abstract: The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. Particular antibodies provided herein include human monoclonal antibodies. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: January 18, 2011
    Assignee: Immunex Corporation
    Inventors: Paul J. Carter, Hongxing Zhou
  • Interleukin-15 receptors
    Patent number: 7863019
    Abstract: There are disclosed Interleukin-15 Receptor (IL-15R) proteins, DNAs and expression vectors encoding IL-15R, and processes for producing IL-15R as products of recombinant cell cultures.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 4, 2011
    Assignee: Immunex Corporation
    Inventors: Dirk M. Anderson, Judith G. Giri
  • METHODS OF USING BTL-II PROTEINS
    Publication number: 20100330104
    Abstract: The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.
    Type: Application
    Filed: March 3, 2010
    Publication date: December 30, 2010
    Applicant: Immunex Corporation
    Inventors: Peter R. Baum, Sabine S. Escobar, Joanne L. Viney
  • Use of Trail Polypeptides to Treat Cancer
    Publication number: 20100323399
    Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
    Type: Application
    Filed: May 13, 2010
    Publication date: December 23, 2010
    Applicant: IMMUNEX CORPORATION
    Inventors: Steven R. Wiley, Raymond G. Goodwin
  • ACPL-related assays
    Patent number: 7838248
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: November 23, 2010
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • Endothelial stem cells, populations, methods of isolation and use thereof
    Patent number: 7833697
    Abstract: The present invention provides stem cells characterized as having the ability to renew and the ability to give rise to endothelial and/or endothelial-like cells, methods of isolating such stem cells and methods of use thereof. Also provided are progeny cells derived from the stem cells of the invention.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: November 16, 2010
    Assignee: Immunex Corporation
    Inventors: William C. Fanslow, III, Anne-Marie C. Rousseau, Thomas O. Daniel
  • Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
    Patent number: 7834157
    Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide probes having defined sequences, processes for producing polypeptides of the LIR family, and antagonistic antibodies to LIR family members. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: November 16, 2010
    Assignee: Immunex Corporation
    Inventor: David J. Cosman
  • Cell culture performance with betaine
    Patent number: 7829309
    Abstract: This invention relates generally to the field of cell culture. More particularly, the invention relates to improving viability of recombinant cell cultures and the yields of secreted polypeptides therefrom by the addition of betaine to the tissue culture medium.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: November 9, 2010
    Assignee: Immunex Corporation
    Inventors: Brian D. Follstad, Anne H. Potter