Patents Assigned to Immusol, Incorporated
  • Inducible SIRNA expression cassette and method of use
    Publication number: 20090133136
    Abstract: An inducible siRNA expression polynucleotide and methods for its use are provided. The expression polynucleotide comprises a bicistronic expression cassette that encodes a repressor and a detectable marker, wherein the repressor controls expression of siRNA expression in the absence of an inducer.
    Type: Application
    Filed: January 18, 2006
    Publication date: May 21, 2009
    Applicant: Immusol Incorporated
    Inventors: Demin Zhou, Jon E. Chatterton, Ning Ke, Jing Zhang, Joshua Bliesath, Henry Li, Flossie Wong-Staal
  • Novel Quinolinium Salts and Derivatives
    Publication number: 20080281105
    Abstract: The present invention relates generally to the synthesis of novel quinolinium salts and derivative compounds. Such salts and compounds are useful for inhibiting the growth of cancer cells.
    Type: Application
    Filed: January 18, 2006
    Publication date: November 13, 2008
    Applicant: IMMUSOL INCORPORATED
    Inventors: James E. Macdonald, Michelle K. Hysell, Dehua Yu, Henry Li, Flossie Wong-Staal
  • Novel assays for assessing cancerous cell growth
    Publication number: 20060234249
    Abstract: The present invention provides novel assays for assessing cancerous cell growth. The invention is useful for the identification and validation of oncogenes and tumor suppressors, as well as for the identification and validation of therapeutic compounds for the treatment of cancer.
    Type: Application
    Filed: April 15, 2005
    Publication date: October 19, 2006
    Applicant: Immusol Incorporated
    Inventors: Ning Ke, De-Hua Yu, Aaron Albers, Gisela Claassen, Henry (Qi-Xiang) Li, Flossie Wong-Staal
  • Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries
    Publication number: 20040096818
    Abstract: The present invention provides a hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.
    Type: Application
    Filed: July 2, 2003
    Publication date: May 20, 2004
    Applicant: Immusol, Incorporated
    Inventors: Jack R. Barber, Peter Welch, Soonpin Yei, Richard Tritz
  • Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries
    Patent number: 6605429
    Abstract: The present invention provides a hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: August 12, 2003
    Assignee: Immusol, Incorporated
    Inventors: Jack R. Barber, Peter Welch, Soonpin Yei, Richard Tritz
  • Substantially complete ribozyme libraries
    Publication number: 20030096399
    Abstract: The present invention provides a high complexity substantially complete hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.
    Type: Application
    Filed: February 5, 2002
    Publication date: May 22, 2003
    Applicant: Immusol Incorporated
    Inventors: Jack Barber, Peter Welch, Xinqiang Li, Richard Tritz
  • Methods and compositions for inhibiting HIV infection of cells by cleaving HIV co-receptor RNA
    Patent number: 5939538
    Abstract: Methods of inhibiting HIV infection by blocking HIV co-receptor RNA expression are provided. Ribozymes which cleave HIV co-receptor RNA and inhibit HIV infection of cells are also provided. Co-receptor targets include fusin and CKR5.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: August 17, 1999
    Assignee: Immusol Incorporated
    Inventors: Markley C. Leavitt, Richard Tritz, Yu Feng, Jack Barber, Mang Yu
  • Ribozyme therapy for the inhibition of restenosis
    Patent number: 5834440
    Abstract: As an effective therapy for restenosis, this invention provides ribozymes and ribozyme delivery systems useful to inhibit abnormal smooth muscle cell proliferation in vascular tissue. Methods of producing ribozymes and gene therapy utilizing these ribozymes also are provided.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: November 10, 1998
    Assignee: Immusol Incorporated
    Inventors: Tsvi Goldenberg, Richard Tritz
  • Anti-HIV ribozymes
    Patent number: 5741706
    Abstract: GUC and GUA ribozymes which cleave HIV RNA are provided. The ribozymes cleave HIV RNA in vitro and in vivo. When the ribozymes are expressed in cells, they inhibit HIV replication in the cells.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: April 21, 1998
    Assignee: Immusol, Incorporated
    Inventors: Markley C. Leavitt, Richard Tritz, Elizabeth Duarte, Jack Barber, Mang Yu