Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.

Abstract: A morphing skin for an air vehicle structure, the skin being formed by a composite material which includes: a multiplicity of fibers, a matrix incorporating the fibers, and a thermo-sensitive material, such as a thermo-plastic. The thermo-sensitive material can be reversibly transitionable in response to a change in temperature, between (i) an ambient temperature mode in which the thermo-sensitive material is capable of transferring loads in the composite material, and (ii) a heated mode in which the ability of the thermo-sensitive material to transfer the loads is reduced. This can allow the stiffness of the skin to be temporarily reduced to enable the skin to be morphed into a different shape.

Abstract: Certain examples described herein relate to modelling a three-dimensional space. Image data from at least one capture device is used to generate a three-dimensional model of the three-dimensional space. In certain examples, the three-dimensional model is segmented into active and inactive portions based on at least one model property. The examples are configured to use the active portions to update the three-dimensional model over time. Registration is also performed to align active portions of the three-dimensional model with inactive portions of the three-dimensional model over time. The registration aligns active portions of the three-dimensional model generated following an observation of a region of the three-dimensional space with inactive portions of the model generated following at least one previous observation of said region.

Abstract: Disclosed herein is a rectifier circuit for receiving an AC signal from a receiver coil in an inductive power transfer system. The circuit is configured to operate at an operating frequency. The circuit comprises a Class-E rectifier; an AC signal supplier configured to supply an AC signal to the rectifier circuit; and a resonant network having an inductor and a capacitor. The resonant network has a resonant frequency, and the ratio of the resonant frequency to the operating frequency is within the range of 1.75 to 3.

Abstract: Devices, systems, and methods for visually depicting a vessel and evaluating treatment options are disclosed.

Abstract: An apparatus and method of assessing a narrowing in a fluid filled tube having a fluid flow pressure wave having a backward-originating pressure component and a forward-originating pressure component without taking a flow velocity measurement, comprising: taking pressure measurements in the tube; separating the pressure components into the backward-originating pressure component and the forward-originating pressure component; identifying a time window when the differential of flow velocity (dU) is minimal or absent; and deriving the backward and forward pressure components for pressure measurements taken in at least the time window.

Abstract: An apparatus and method of assessing a narrowing in a fluid filled tube having a fluid flow pressure wave having a backward-originating pressure component and a forward-originating pressure component without taking a flow velocity measurement, comprising: taking pressure measurements in the tube; separating the pressure components into the backward-originating pressure component and the forward-originating pressure component; identifying a time window when the differential of flow velocity (dU) is minimal or absent; and deriving the backward and forward pressure components for pressure measurements taken in at least the time window.

Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.

Abstract: Devices, systems, and methods configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel, provide visual depictions of vessel that allow assessment of the vessel and, in particular, any stenosis or lesion of the vessel, simulate one or more treatment options for the vessel, and perform treatment on any stenosis or lesion of the vessel, including guiding placement of one or more treatment devices are provided. The method can include obtaining pressure measurements from first and second instruments positioned within a vessel of a patient during a diagnostic procedure where the second instrument is moved longitudinally through the vessel; identifying a treatment option based on the obtained pressure measurements; and performing the identified treatment option, wherein a user display guides placement of one or more treatment devices associated with the identified treatment option.

Abstract: An apparatus and method of assessing a narrowing in a fluid filled tube having a fluid flow pressure wave having a backward-originating pressure component and a forward-originating pressure component without taking a flow velocity measurement, comprising: taking pressure measurements in the tube; separating the pressure components into the backward-originating pressure component and the forward-originating pressure component; identifying a time window when the differential of flow velocity (dU) is minimal or absent; and deriving the backward and forward pressure components for pressure measurements taken in at least the time window.

Abstract: The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certain integrin antagonists.

Abstract: The invention relates to a doable-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the IKK-B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases, caused by the expression or activation of the IKK-B gene using the pharmaceutical composition; and methods for inhibiting the expression of the IKK-B gene in a cell.

Abstract: A coating material (20) for coating a machine component (10), especially a gas turbine or a part thereof, comprises a mixture of at least a refractory material and an indicator material having an optical emission (e.g. fluorescence) spectrum which varies in response to a physical parameter of the coated component. In a preferred embodiment, the coating consists of yttrium aluminium garnet (YAG) or yttrium stabilized zirconium. The dopant is preferably a rare earth metal, e.g. Eu, Tb, Dy.

Abstract: The present invention relates to polyvinyl ethers and to their use as supports for synthetic methods (organic synthesis, peptide synthesis, oligonucleotide synthesis, oligosaccharide synthesis or any other synthetic procedure) and to their use for chromatographic applications (such as affinity chromatography), immobilisation of enzymes, reagents or catalysts.

Abstract: A stent for supporting part of a blood vessel includes a supporting portion around which or within which part of an intact blood vessel, other than a graft, can be placed so that the stent internally or externally supports that part of the blood vessel. The supporting portion of the stent is of a shape and/or orientation whereby flow within the vessel is caused to follow a non-planar curve. By maintaining a non-planar curvature in the vessel itself, favorable blood flow velocity patterns can be achieved through the generation in the vessel of a swirl flow. Failures in such vessels through diseases such as thrombosis, atherosclerosis, intimal hyperplasia or through blockage, kinking or collapse, can be significantly reduced.

Abstract: An audio signal processor includes a tone control (23). The tone control comprises two low-pass filters (221, 222) operating in current-mode and a subtractor (223) which subtracts the output currents of the filters to produce a band-pass characteristic. Each filter is a tuneable log-domain current-mode filter comprising MOS transistors operating in weak inversion. The tone control is useful in audio signal processors, hearing aids and single-channel and multi-channel Cochlear implants.

Abstract: A microfabricated plasma generator and a method of generating a plasma, the plasma generator comprising: a substrate chip; a chamber defined by the substrate chip, the chamber including an inlet port through which analyte is in use delivered, an outlet port and a plasma-generation region in which a plasma is in use generated; and first and second electrodes across which a voltage is in use applied to generate a plasma in the plasma-generation region.

Abstract: The present invention provides a method and apparatus for the production of nanoparticles using a continuous flow miniaturised reaction vessel. In particular, the invention provides a method for preparing nanoparticles by a direct one-stage process.

Abstract: An apparatus (8, 14) for wavelength shifting light from a first frequency ?1 to a second frequency ?2 is provided in the form of a semiconductor intersubband laser (8) lasing at its intersubband frequency ?3. The output light is wavelength shifted to a frequency ?2=?1+n?3, where n is a non-zero integer ( . . . , ?2, ?1, 1, 2, . . . ). The wavelength shifted light ?2 may be amplitude modulated and/or frequency modulated to impart information upon it. The wavelength shifting is a coherent process allowing for the possibility of coherent communication techniques to be used.

Abstract: Smoothly curved protuberances (8, 26, 34) are added to an elongate body (2, 16, 18, 20, 22, 32) to modify the fluid flow to reduce the drag Force Fdrag and the forces induced by vortex shedding Fvortex. The protuberances can be arranged in diametrically opposed pairs with longitudinally adjacent pairs having different radial directions first to cope with fluid flow from a variety of different directions.